Pemphigoid is a rare blistering disorder, which usually occurs in later life. The blisters come up on the skin and, less often, in the mouth too. Pemphigoid is classed as an autoimmune disease. For an unknown reason, antibodies form in the blood and then attack the structures holding the outer layer of the skin onto the deeper layers. This leads to splitting of the skin and so into blisters. An itchy rash may be present for some weeks before any blisters come up. The blisters have thick roofs, and can get quite large and tense before they burst. Most contain clear fluid but in a few this is bloodstained. Your doctor may perform a skin biopsy and special tests (immunofluorescence) to confirm the diagnosis.
Pemphigus vulgaris is a rare autoimmune skin disease. Pemphigus vulgaris may cause severe blistering of the skin and the mucous membranes lining the mouth, nose, throat and genital area. Blisters develop in the upper layer of the skin, and have a thin and fragile outer surface that breaks away easily to leave raw areas (erosions) that can be extensive and painful. Pemphigus vulgaris does not go away by itself, and always needs assessment and treatment supervised by a Dermatologist. The immune system makes antibodies (auto antibodies) that attack the skin and mucous membrane leading to damage that causes blisters to develop. Your doctor may perform a skin biopsy and special tests (immunofluorescence) to confirm the diagnosis.
Staphylococcal Scalded Skin Syndrome
Staphylococcal scalded skin syndrome is a widespread painful rash caused by bacteria called Staphylococcus aureus, which produces a toxin that damages the outer layer of the skin causing it to be shed. The skin then resembles a scald or burn. Affected patients are miserable, feverish and may not want to be held or touched.