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Prof Yeoh Khay Guan

Photo of Prof Yeoh Khay Guan
MBBS, Mmed (Int Med), FRCP, FRCP (Glasg), FAMS
Senior Consultant, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
Senior Consultant, National University Cancer Institute, Singapore
Chief Executive, National University Health System (NUHS)
Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore (NUS) 
Cancer, Medicine
Sub Specialty:
Gastroenterology & Hepatology
Medical and Surgical Conditions:
Esophageal Cancer, Functional Dyspepsia, Gastric Cancer (Stomach Cancer), Gastroesophageal Reflux Disease (GERD), Gastrointestinal Stromal Tumour (GIST), Helicobactor Pylori
Special Interest:
Gastrointestinal Cancer - Early detection and Biomarker discovery
National University Hospital
National University Cancer Institute, Singapore
National University Health System
Dr. Yeoh practises as a Senior Consultant at the Division of Gastroenterology and Hepatology, National University Hospital (NUH).

His research interest is in enhancing the early detection of gastric and colorectal cancers. He is the Lead Principal Investigator of the Singapore Gastric Cancer Consortium, a national flagship research group, which aims to improve the outcomes for gastric cancer by early detection, improving treatment and advancing the understanding of gastric carcinogenesis. He has published over 170 peer-reviewed papers in international journals. He also chairs the National Colorectal Cancer Screening Committee of the Health Promotion Board, Ministry of Health, which recommends guidelines for the national colorectal screening programme in Singapore.

Dr. Yeoh received his MBBS (Bachelor of Medicine, Bachelor of Surgery) from NUS in 1987. He trained in internal medicine and gastroenterology at NUH. He is a Fellow of the Academy of Medicine, Singapore, Fellow of the Royal College of Physicians of London and Glasgow, and a member of the American Gastroenterology Association and American Society of Gastrointestinal Endoscopy. He also serves as a reviewer for several journals and grant funding agencies. He has received several international awards for his research work, including the Nishi-Takahashi Lectureship at the 9th International Gastric Cancer Conference in 2011 and the Emerging Leader Lectureship award by the Journal of Gastroenterology & Hepatology Foundation in 2006.

Awards and Honours

Public Administration Medal (Silver) 2016, National Day Award
National Outstanding Clinician Scientist Award, National Medical Excellence Awards 2013, Ministry of Health
Nishi-Takahashi Memorial Plenary Lectureship, 9th International gastric Cancer Conference, 2011
21th Seah Cheng Siang Memorial Lecture, 45th Singapore Malaysia Congress of Medicine, 2011
Faculty Research Excellence Award 2009, School of Medicine, National University of Singapore
Excellent Service Award (Silver), 2009
Best Oral Presentation Award for Research in Medical Disciplines, 2008 National Healthcare Group Annual Scientific Congress
NHG Quality Pillar Award, 2007 – 2008
Public Administration Medal (Bronze) 2007, National Day Award
JGH Emerging Leader Lectureship Award, October 2006
NHG Outstanding Citizenship Award 2005

Research and Publications

  1. Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VH, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Zhu F, So JB, Teh BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L. ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. Gastroenterology 2016 Oct;151(4):637-650
  2. Roy RK, Hoppe MM, Srivastava S, Samanta A, Sharma N, Tan KT, Yang H, Voon DC, Pang B, Teh M, Murata-Kamiya N, Hatakeyama M, Chang YT, Yong WP, Ito Y, Ho KY, Tan P, Soong R, Koeffler PH, Yeoh KG, Jeyasekharan AD. CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer. Oncotarget. 2016 Aug 23;7(34):55290-55301
  3. Tan P, Yeoh KG. Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma. Gastroenterology. 2015 Oct;149(5):1153–1162
  4. Lin SJ, Gagnon-Bartsch JA, Tan IB, Earle S, Ruff L, Pettinger K, Ylstra B, van Grieken N, Rha SY, Chung HC, Lee JS, Cheong JH, Noh SH, Aoyama T, Miyagi Y, Tsuburaya A, Yoshikawa T, Ajani JA, Boussioutas A, Yeoh KG, Yong WP, So J, Lee J, Kang WK, Kim S, Kameda Y, Arai T, Zur Hausen A, Speed TP, Grabsch HI, Tan P. Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas. Gut. 2015 Nov;64(11):1721-31
  5. Ainslie-Waldman CE, Koh WP, Jin A, Yeoh KG, Zhu F, Wang R, Yuan JM, Butler LM. Coffee intake and gastric cancer risk: the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):638-47
  6. Zhou HJ, Li SC, Naidoo N, Zhu F, Yeoh KG. Empirical evidence of the continuing improvement in cost efficiency of an endoscopic surveillance programme for gastric cancer in Singapore from 2004 to 2010. BMC Health Serv Res. 2013 Apr 15;13:139.
  7. Wang T, Yeoh KG, Salto-Tellez M. Lgr5 expression is absent in human premalignant lesions of the stomach. Gut. 2012 Dec;61(12):1777-8.
  8. Zang ZJ, Cutcutache I, Poon SL, Zhang SL, McPherson J, Tao J, Rajasegaran V, Heng HL, Deng N, Gan A, Lim KH, Ong CK, Huang DC, Chin SY, Tan IB, Ng CCY, Yu W, Wu Y, Lee M, Wu J, Poh D, Wan WK, Rha SY, So J, Salto-Tellez M, Yeoh KG, Wong WK, Zhu YJ, Futreal A, Pang B, Ruan Y, Hillmer A, Bertrand D, Nagarajan N, Rozen S, Teh BT, Tan P. Exome Sequencing of Gastric Adenocarcinoma Reveals Recurrent Somatic Mutations in Cell Adhesion and Chromatin Remodeling Genes. Nature Genetics 2012 May, 44(5):570-4.
  9. Zhou HJ, So JB, Yong WP, Luo N, Zhu F, Naidoo N, Li SC, Yeoh KG. Validation of the functional assessment of cancer therapy-gastric module for the Chinese population. Health Qual Life Outcomes. 2012 Nov 30;10:145.
  10. Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee J, Tan SH, Wu J, Lee MH, Ooi CH, Rha SY, Wong WK, Boussioutas A, Yeoh KG, So J, Yong WP, Tsuburaya A, Grabsch H, Toh HC, Rozen S, Cheong JH, Noh SH, Wan WK, Ajani JA, Lee JS, Tellez MS, Tan P. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology. 2011 Aug;141(2):476-485.e11.
  11. Huang Z, Teh SK, Zheng W, Lin K, Ho KY, Teh M, Yeoh KG. In vivo detection of epithelial neoplasia in the stomach using image-guided Raman endoscopy. Biosens Bioelectron. 2010 Oct 15;26(2):383-9.
  12. Huang Z, Bergholt MS, Zheng W, Lin K, Ho KY, Teh M, Yeoh KG. In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy. J Biomed Opt. 2010 May-Jun;15(3):037017.
  13. Gong M, Ling SS, Lui SY, Yeoh KG, Ho B. Helicobacter pylori gamma-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease. Gastroenterology. 2010 Aug;139(2):564-73.
  14. Teh SK, Zheng W, Ho KY, Teh M, Yeoh KG, Huang Z. Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach. Br J Surg. 2010 Apr;97(4):550-7.
  15. Huang ZW, Seng KT, Zheng W, Mo JH, Lin K, Shao XZ, Ho KY, Teh M, Yeoh KG. Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy. Optics Letters 2009; 34 (6): 758-760
  16. Leung WK, Wu MS, Kakugawa Y, Kim JJ, Yeoh KG, Goh KL, Wu KC, Wu DC, Sollano J, Kachintorn U, Gotoda T, Lin JT, You WC, Ng EKW, Sung JJY, Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncology 2008;9:279-287
  17. Wong MC, Ching JY, Chiu HM, Wu KC, Rerknimitr R, Li J, Wu DC, Goh KL, Matsuda T, Kim HS, Leong R, Yeoh KG, Chong VH, Sollano JD, Ahmed F, Menon J, Ng SC, Wu JC, Chan FK, Sung JJ. Risk of Colorectal Neoplasia in Individuals With Self-Reported Family History: A Prospective Colonoscopy Study from 16 Asia-Pacific Regions. Am J Gastroenterol. 2016 Nov;111(11):1621-1629
  18. Chiu HM, Ching JY, Wu KC, Rerknimitr R, Li J, Wu DC, Goh KL, Matsuda T, Kim HS, Leong R, Yeoh KG, Chong VH, Sollano JD, Ahmed F, Menon J, Sung JJ. A Risk-scoring System Combined with a Fecal Immunochemical Test Is Effective in Screening High-risk Subjects for Early Colonoscopy to Detect Advanced Colorectal Neoplasms. Gastroenterology. 2016 Mar; 150(3):617-625.e3
  19. Corte C, Zhang L, Chen J, Westbury S, Shaw J, Yeoh KG, Leong R. Validation of the Asia Pacific Colorectal Screening (APCS) score in a western population. An alternative screening tool. J Gastroenterol Hepatol. 2016 Feb;31(2):370-375
  20. Bergholt MS, Zheng W, Lin K, Wang J, Xu H, Ren JL, Ho KY, Teh M, Yeoh KG, Huang Z. Characterizing variability of in vivo Raman spectroscopic properties of different anatomical sites of normal colorectal tissue towards cancer diagnosis at colonoscopy. Anal Chem. 2015 Jan 20;87(2):960-966
  21. Sung JJ, Ng SC, Chan FK, Chiu HM, Kim HS, Matsuda T, Ng SS, Lau JY, Zheng S, Adler S, Reddy N, Yeoh KG, Tsoi KK, Ching JY, Kuipers EJ, Rabeneck L, Young GP, Steele RJ, Lieberman D, Goh KL. An updated Asia Pacific Consensus Recommendations on colorectal cancer screening. Gut. 2015;64:121-132
  22. Yeoh KG, Ho KY, Chiu HM, Zhu F, Ching JYL, Wu DC, Matsuda T, Byeon JS, Lee SK, Goh KL, Sollano J, Rerknimitr R, Leong R, Tsoi K, Lin JT, Sung JJY. The Asia-Pacific Colorectal Screening score: a validated tool that stratifies Risk for colorectal advanced neoplasia in asymptomatic Asian subjects. Gut 2011 Sep;60(9):1236-41