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Prof Yeoh Khay Guan

Photo of Prof Yeoh Khay Guan
Designations:
  • Senior Consultant, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
  • Irene Tan Liang Kheng Professor in Medicine and Oncology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore (NUS)
Qualifications:
MBBS, M.Med (Int Med), FRCP, FRCP (Glasg), FAMS
Specialties:
Medicine
Sub-specialties:
Gastroenterology & Hepatology
Special Interests:
Gastrointestinal Cancer - Early detection and Biomarker discovery

Biosketch

Dr. Yeoh practises as a Senior Consultant at the Division of Gastroenterology and Hepatology, National University Hospital (NUH).

His research interest is in enhancing the early detection of gastric and colorectal cancers. He is the Lead Principal Investigator of the Singapore Gastric Cancer Consortium, a national flagship research group, which aims to improve the outcomes for gastric cancer by early detection, improving treatment and advancing the understanding of gastric carcinogenesis. He has published over 180 peer-reviewed papers in international journals. He also chairs the National Colorectal Cancer Screening Committee of the Health Promotion Board, Ministry of Health, which recommends guidelines for the national colorectal screening programme in Singapore.

Dr. Yeoh received his MBBS (Bachelor of Medicine, Bachelor of Surgery) from NUS in 1987. He trained in internal medicine and gastroenterology at NUH. He is a Fellow of the Academy of Medicine, Singapore, Fellow of the Royal College of Physicians of London and Glasgow, and a member of the American Gastroenterology Association and American Society of Gastrointestinal Endoscopy. He has received several awards for his research work, including the Nishi-Takahashi Lectureship at the 9th International Gastric Cancer Conference in 2011, the National Medical Excellence Award as Outstanding Clinician Scientist from the Ministry of Health in 2013, and the Public Administration Medal (Silver) in 2016 for his contributions to medical education and healthcare.

Awards

  • 2020 – 20th Malaysian Society of Gastroenterology (MSGH) Oration, Annual Scientific Meeting of the Malaysian Society of Gastroenterology, Malaysia, 27-29 November 2020
  • 2016 – National Day Awards - Public Administration Medal (Silver)

Journals & Publications

  1. So JBY, Kapoor R, Zhu F, Koh C, Zhou L, Zou R, Tang YC, Goo PCK, Rha SY, Chung HC, Yoong J, Yap CT, Rao J, Chia CK, Tsao S, Shabbir A, Lee J, Lam KP, Hartman M, Yong WP, Too HP, Yeoh KG. Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population. Gut. 2020. Article in press.
  2. Liou JM, Malfertheiner P, Lee YC, Sheu BS, Sugano K, Cheng HC, Yeoh KG, Hsu PI, Goh KL, Mahachai V, Gotoda T, Chang WL, Chen MJ, Chiang TH, Chen CC, Wu CY, Leow AH, Wu JY, Wu DC, Hong TC, Lu H, Yamaoka Y, Megraud F, Chan FKL, Sung JJ, Lin JT, Graham DY, Wu MS, El-Omar EM. Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus. Gut. 2020;69(12):2093-2112.
  3. Tan SH, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, Oshima M, Tsuji T, Phuah P, Tan LT, Wong E, Fatehullah A, Sheng T, Ho SWT, Grabsch HI, Srivastava S, Teh M, Denil S, Mustafah S, Tan P, Shabbir A, So J, Yeoh KG, Barker N. AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 2020;578(7795):437-43.
  4. Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, Lee M, Tay S, Das K, Xing M, Fatehullah A, Alkaff SMF, Lim TKH, Lee J, Ho KY, Rozen SG, Teh BT, Barker N, Chia CK, Khor C, Ooi CJ, Fock KM, So J, Lim WC, Ling KL, Ang TL, Wong A, Rao J, Rajnakova A, Lim LG, Yap WM, Teh M, Yeoh KG, Tan P. Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer. Cancer Cell. 2018;33(1):137-50.e5.
  5. Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, Lee M, Tay S, Das K, Xing M, Fatehullah A, Alkaff SMF, Lim TKH, Lee J, Ho KY, Rozen SG, Teh BT, Barker N, Chia CK, Khor C, Ooi CJ, Fock KM, So J, Lim WC, Ling KL, Ang TL, Wong A, Rao J, Rajnakova A, Lim LG, Yap WM, Teh M, Yeoh KG, Tan P. Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer. Cancer Cell. 2018;33(1):137-50.e5.
  6. Qamra A, Xing M, Padmanabhan N, Kwok JJT, Zhang S, Xu C, Leong YS, Lim APL, Tang Q, Ooi WF, Lin JS, Nandi T, Yao X, Ong X, Lee M, Tay ST, Keng ATL, Santoso EG, Ng CCY, Ng A, Jusakul A, Smoot D, Ashktorab H, Rha SY, Yeoh KG, Yong WP, Chow PKH, Chan WH, Ong HS, Soo KC, Kim KM, Wong WK, Rozen SG, Teh BT, Kappei D, Lee J, Connolly J, Tan P. Epigenomic promoter alterations amplify gene isoform and immunogenic diversity in gastric adenocarcinoma. Cancer Discovery. 2017;7(6):630-51.
  7. Tan P, Yeoh KG. Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma. Gastroenterology. 2015;149(5):1153-62.e3.
  8. Bergholt MS, Zheng W, Ho KY, Teh M, Yeoh KG, Yan So JB, Shabbir A, Huang Z. Fiberoptic confocal raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett's esophagus. Gastroenterology. 2014;146(1):27-32.
  9. Zang ZJ, Cutcutache I, Poon SL, Zhang SL, McPherson JR, Tao J, Rajasegaran V, Heng HL, Deng N, Gan A, Lim KH, Ong CK, Huang D, Chin SY, Tan IB, Ng CCY, Yu W, Wu Y, Lee M, Wu J, Poh D, Wan WK, Rha SY, So J, Salto-Tellez M, Yeoh KG, Wong WK, Zhu YJ, Futreal PA, Pang B, Ruan Y, Hillmer AM, Bertrand D, Nagarajan N, Rozen S, Teh BT, Tan P. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nature Genetics. 2012;44(5):570-4.
  10. Dan YY, Chuah BYS, Koh DCS, Yeoh KG. Screening Based on Risk for Colorectal Cancer Is the Most Cost-Effective Approach. Clinical Gastroenterology and Hepatology. 2012;10(3):266-71.e6.

Contact

Appt Tel:
Fax:
+65 6772 4361