Associate Professor Loke Kah Yin is currently Senior Consultant and Head of the Paediatric Endocrinology Division at the Department of Paediatrics in NUH.
He obtained his basic medical degree (MBBS) from NUS in 1984. From 1987 to 1989, he received his general paediatric training at NUH, which culminated in his postgraduate degree (Masters of Medicine in Paediatrics) in 1989. In 1990, A/Prof Loke joined NUS as teaching faculty, choosing Paediatric Endocrinology as his subspecialty.
He became a Member of the Royal College of Physicians (UK) in 1990, and was elected a Fellow of the Royal College of Physicians (Edinburgh) in 1998 and a Fellow of the Royal College of Paediatrics and Child Health in 2002. His specialist training in clinical paediatric endocrinology was undertaken at The Children's Hospital, Sydney, from 1991 to 1992, under the tutelage of Professor Martin Silink and Dr Chris Cowell. This was followed by one year's research training at the UCLA Medical Centre, Los Angeles, from 1992 to 1993, under the tutelage of Professor Barbara Lippe. Following training, he returned to NUH and established the clinical, research and teaching arms of the Paediatric Endocrinology service at the Department of Paediatrics, NUH. The clinical service of Paediatric Endocrinology encompasses growth and pubertal disorders in childhood, thyroid, adrenal, pituitary disorders, disorders of sexual development, bone diseases and endocrine problems in survivors of childhood cancer.
His research interests include the genetics of adrenal disorders, pseudohypoparathyroidism and obesity. A/Prof Loke also obtained the Doctorate of Medicine for his Thesis on the Molecular Pathogenesis of Congenital Adrenal Hyperplasia and X-Linked Adrenal Hypoplasia Congenita in 2002. For his work in Paediatric Endocrinology, he was awarded the Singapore Youth Award in 2000 and the Haridas Gold Medal for Paediatric research in Singapore in 2001.
As Principle Investigator
- 2009 – 2012: Ambulatory diastolic blood pressure predicts microalbuminuria in children and adolescents with diabetes mellitus (NKFRC/2009/01/09)
- 2003 – 2006: Characterisation of CYP11B1 mutations in 11-beta hydroxylase deficiency (NMRC/0773/2003)
- 2000 – 2005: Characterising normative values for areal and volumetric bone mineral density and body composition in Singapore children and adolescents: Towards an accurate assessment of therapeutic intervention in chronic paediatric disease and childhood obesity. (NMRC/0453/2000)
- 1999: Characterising normative values for areal and volumetric bone mineral density and body composition in Singapore children and adolescents: Towards an accurate assessment of therapeutic intervention in chronic paediatric disease and childhood obesity. (NMRC/0453/2000)
- 1996: Molecular characterisation of the chromosome 6p CYP21 gene in 21-hydroxylase deficient form of congenital adrenal hyperplasia in Singapore (Principal Investigator – NMRC/0152/1996)
- 1994: Characterisation of an Xp21 microdeletion/mutation syndrome in a family with adrenal hypoplasia congenital (NMRC/0047/1994 [RP 3940359/N])
- 2008 – 2010: To determine the bone mineralisation and bone strength of children with chronic diseases using Dual X-ray absorptiometry (DEXA) and the paediatric Contact Ultrasonic Bone Analyser (CUBAResearch), and to determine its association with chronic steroid therapy (NMRC/0978/2005)
- 2002: Characterising normative values for calcaneal broadband nultrasound attenuation in Singapore children and adolescents: towards an accurate assessment of bone strength and fracture risk in chronic paediatric disease (NHG Research Fund)
- 2001: Characterisation of the genetics and complications of childhood obesity (NMRC/0563/2001)
- 2000: Expression studies of a novel 111 bp duplication in exon 1 in the pathogenicity of simple virilising congenital adrenal hyperplasia (RP3992320)