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A/Prof Loke Kah Yin

Photo of A/Prof Loke Kah Yin
MBBS (S'pore), MMed (Paeds) (S'pore), MRCP (UK), FRCP (Edin), FRCPCH (UK), FAMS, MD
Head & Senior Consultant, Division of Paediatric Endocrinology, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital

Associate Professor, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (Research Specialty: Endocrinology)​

Sub Specialty:
Paediatric Endocrinology
Medical and Surgical Conditions:
Congenital Hypothyroidism (Children), Disorders of Sex Development (Children), Graves' Disease (Children), Growth Disorders in Children, Obesity (Children), Osteoporosis (Children), Pubertal Disorders in Children, Turner Syndrome (Children), Type 1 and Type 2 Diabetes Mellitus (Children)
Special Interest:


​Genetics and epidemiology of the inherited adrenal disorders: congenital adrenal hyperplasia and X-linked congenital adrenal hypoplasia


National University Hospital
National University Health System
Associate Professor Loke Kah Yin is currently Senior Consultant and Head of the Paediatric Endocrinology Division at the Department of Paediatrics in NUH.

He obtained his basic medical degree (MBBS) from NUS in 1984. From 1987 to 1989, he received his general paediatric training at NUH, which culminated in his postgraduate degree (Masters of Medicine in Paediatrics) in 1989. In 1990, A/Prof Loke joined NUS as teaching faculty, choosing Paediatric Endocrinology as his subspecialty.

He became a Member of the Royal College of Physicians (UK) in 1990, and was elected a Fellow of the Royal College of Physicians (Edinburgh) in 1998 and a Fellow of the Royal College of Paediatrics and Child Health in 2002. His specialist training in clinical paediatric endocrinology was undertaken at The Children's Hospital, Sydney, from 1991 to 1992, under the tutelage of Professor Martin Silink and Dr Chris Cowell. This was followed by one year's research training at the UCLA Medical Centre, Los Angeles, from 1992 to 1993, under the tutelage of Professor Barbara Lippe. Following training, he returned to NUH and established the clinical, research and teaching arms of the Paediatric Endocrinology service at the Department of Paediatrics, NUH. The clinical service of Paediatric Endocrinology encompasses growth and pubertal disorders in childhood, thyroid, adrenal, pituitary disorders, disorders of sexual development, bone diseases and endocrine problems in survivors of childhood cancer.

His research interests include the genetics of adrenal disorders, pseudohypoparathyroidism and obesity. A/Prof Loke also obtained the Doctorate of Medicine for his Thesis on the Molecular Pathogenesis of Congenital Adrenal Hyperplasia and X-Linked Adrenal Hypoplasia Congenita in 2002. For his work in Paediatric Endocrinology, he was awarded the Singapore Youth Award in 2000 and the Haridas Gold Medal for Paediatric research in Singapore in 2001.

As Principle Investigator
  • 2009 – 2012: Ambulatory diastolic blood pressure predicts microalbuminuria in children and adolescents with diabetes mellitus (NKFRC/2009/01/09)
    • Funding Agency: NKF
  • 2003 – 2006: Characterisation of CYP11B1 mutations in 11-beta hydroxylase deficiency (NMRC/0773/2003)
    • Funding Agency: NMRC
  • 2000 – 2005: Characterising normative values for areal and volumetric bone mineral density and body composition in Singapore children and adolescents: Towards an accurate assessment of therapeutic intervention in chronic paediatric disease and childhood obesity. (NMRC/0453/2000)
    • Funding Agency: NMRC
  • 1999: Characterising normative values for areal and volumetric bone mineral density and body composition in Singapore children and adolescents: Towards an accurate assessment of therapeutic intervention in chronic paediatric disease and childhood obesity. (NMRC/0453/2000)
    • Funding Agency: NMRC
  • 1996: Molecular characterisation of the chromosome 6p CYP21 gene in 21-hydroxylase deficient form of congenital adrenal hyperplasia in Singapore (Principal Investigator – NMRC/0152/1996)
    • Funding Agency: NMRC
  • 1994: Characterisation of an Xp21 microdeletion/mutation syndrome in a family with adrenal hypoplasia congenital (NMRC/0047/1994 [RP 3940359/N])
    • Funding Agency: NMRC

As collaborator:
  • 2008 – 2010: To determine the bone mineralisation and bone strength of children with chronic diseases using Dual X-ray absorptiometry (DEXA) and the paediatric Contact Ultrasonic Bone Analyser (CUBAResearch), and to determine its association with chronic steroid therapy (NMRC/0978/2005)
    • Funding Agency: NMRC
  • 2002: Characterising normative values for calcaneal broadband nultrasound attenuation in Singapore children and adolescents: towards an accurate assessment of bone strength and fracture risk in chronic paediatric disease (NHG Research Fund)
    • Funding Agency: NHG
  • 2001: Characterisation of the genetics and complications of childhood obesity (NMRC/0563/2001)
    • Funding Agency: NMRC
  • 2000: Expression studies of a novel 111 bp duplication in exon 1 in the pathogenicity of simple virilising congenital adrenal hyperplasia (RP3992320)
    • Funding Agency: NMRC

Awards and Honours

  • NUS Annual Teaching Excellence Award, 2008/2009
  • Faculty Teaching Excellence Award, 2008 – 2009
  • Excellent Service Silver Award 2009
  • Asia Pacific Paediatric Endocrine Society (APPES) Teaching Award, 2008
  • NUH Long Service Award, 2008 (20 years)
  • Faculty Teaching Excellence Award, NUS: 2006/2007
  • Outstanding Researcher Award, Faculty of Medicine, NUS:  2002
  • 15th Haridas Memorial Lecture and Gold Medal: 2002
  • Postgraduate Teaching Excellence Award,  NUH: 2001
  • Best Clinical Science Poster Award, 5th NUH-NUS Annual Scientific Meeting: 2001
  • Singapore Youth Award (Science & Technology): 2000
  • JSPS award for metabolic diseases at Kurume University (1997, 1998)
  • China Medical Board Fellowship for paediatric endocrine subspecialty training at The Children’s Hospital, Sydney (1991–  1992) and UCLA Medical Centre, (1992– 1993)
  • Nestle Silver Medal (MMed Paediatrics examination): 1989
  • PSC Merit Scholarship Award: 1979

Professional Memberships

  • Honorary Secretary of the Asia Pacific Paediatric Endocrine Society (2002– 2008)   
  • Screening Editor, Annals Academy of Medicine (2000– 2013)
  • Editorial Board, Hormone Research (2008 till present)
  • Royal College of Physicians (Edinburgh) (Fellow)
  • Royal College of Paediatrics and Child Health (Fellow)
  • Endocrine and Metabolic Society of Singapore (Member)

Research and Publications


Appt Tel:
+65 6779 7486