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Prof Lim Seng Gee

Photo of Prof Lim Seng Gee
MBBS (Hons Monash), FRACP, MD (Monash), FAMS, Cert Immunology (King's College)
Senior Consultant, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
Senior Consultant, Liver Transplantation, National University Centre for Organ Transplantation, National University Hospital
Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
Director of Hepatology services, Division of Gastroenterology and Hepatology, NUH
Expert panel member, Centre for Drug Administration (CPA) and Centre for Drug Evaluation (CDE), Ministry of Health, Singapore
Chairman, Singapore Hepatitis Conference (annual), inaugural conference 2014
Medicine, Organ Transplantation
Sub Specialty:
Gastroenterology & Hepatology, Liver Transplantation
Medical and Surgical Conditions:
Autoimmune Hepatitis, Bile Duct Cancer, Gallbladder Cancer, Hepatitis B, Hepatitis C, Hepatocellular Carcinoma, Liver Cancer, Liver Cirrhosis, Liver Transplant, Non-alcoholic Steatohepatitis (NASH), Pancreatic Cancer, Primary Biliary Cirrhosis (PBC)
National University Hospital
National University Cancer Institute, Singapore
National University Health System
Prof Lim currently serves as a Senior Consultant at the Division of Gastroenterology and Hepatology in the National University Hospital, Singapore. He is also a Professor in the Yong Loo Lin School of Medicine, National University of Singapore.

Prof Lim attained his basic medical degree with honours (MBBS Hons) from the University of Monash, Melbourne, Australia. He later pursued a doctorate degree (MD) in Monash and was awarded the FRACP (Australia), FRCP (London), FAMS (Gasteroenterology, Singapore).

His main clinical work focuses on the treatment of viral hepatitis (esp. B and C), liver disease and liver cancer. Prof Lim's research activities include leadership in Hepatology research, which focuses on improving treatment for chronic hepatitis B and C, pathophysiology of hepatitis B disease, HBV virology, immunological mechanisms of HBeAg seroconversion, and loss of immune tolerance to hepatitis B virus. He also has an interest in pathophysiology and treatment of liver cancer, primary hepatocyte culture, hepatocyte function, drug related liver disease and non-alcoholic fatty liver disease. Prof Lim has over 100 publications in peer-reviewed journals and sits on the editorial board of Liver International and He has received over S$5 million in research grants and is a reviewer for Singapore's grant funding agencies and the American Association for Liver Disease Annual Meeting.

Prof Lim also sits on the Advisory Board of Novartis Pharmaceuticals, Idenix Pharmaceuticals, Bristol Myers Squibb Pharmaceuticals and is on the Speaker's Bureau for GlaxoSmithKline and Schering Plough Pharmaceuticals. Prof Lim has been an invited speaker at AASLD, EASL and APASL in 2013, 2014 and is a regular speaker at numerous International and Regional meetings on liver disease and viral hepatitis.

Awards and Honours

Mathematics prize, MelbourneGrammar School, 1973
Runner-up for Final Year Clinical Prize,AlfredHospital, 1980. Second Class (Upper) honours 1980. Twentieth in class of 160.
Seah Cheng Siang Travelling Fellowship, 1995
Best poster award, Annual Scientific Meeting, Annual Scientific Meeting, Gastroenterological Society of Singapore, 2000.
Best oral presentation, Asia Pacific Association for Study of Liver Disease,Kyoto,Japan, 2007
Best poster award, Asia Pacific Association for Study of Liver Disease,Kyoto,Japan, 2007
Best oral presentation, Gastroenterology Society of Singapore Annual Scientific Meeting 2007
Presidential poster of distinction, American Association for Study of Liver Disease 2007
Best poster award, Asia Pacific Association for Study of Liver, Bangkok 2011

Professional Memberships

Fellow of the Royal Australasian College of Physicians
Member, Gastroenterological Society of Singapore
Member, Gastroenterological Society of Australia
Member, Society of Infectious Diseases, Singapore
Member, International Society of Mucosal Immunology
Fellow,Academy of Medicine ofSingapore
Member, British Society of Gastroenterology
Member, American Gastroenterological Association
Member,Singapore Society of Transplantation
Member, American Association for Liver Disease
Council Member, Asia Pacific Association for Study of Liver 2006

Research and Publications

  • ​Lee GH, Lim SG. Editorial: IDASPHERE phase I trial for chemoembolisation of HCC. Aliment Pharmacol Ther. 2014 Jul;40(2):209-10. doi: 10.1111/apt.12811.
  • Lesmana CR, Jackson K, Lim SG, Sulaiman A, Pakasi LS, Gani RA, Hasan I, Sulaiman AS, Lesmana LA, Hammond R, Revill P, Locarnini S, Bowden SD. Clinical significance of hepatitis B virion and SVP productivity: relationships between intrahepatic and serum markers in chronic hepatitis B patients. United European Gastroenterol J. 2014 Apr;2(2):99-107. doi: 10.1177/2050640614525151.
  • Tan W, Li Y, Lim SG, Tan TM. miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma. World J Gastroenterol. 2014 May 28;20(20):5962-5972. Review.
  • Dan YY, Lim SG. Commentary: vitamin D deficiency and liver cancer - cause, effect or myth? Aliment Pharmacol Ther. 2014 Jun;39(12):1429. doi: 10.1111/apt.12768.
  • Wong QW, Li J, Ng SR, Lim SG, Yang H, Vardy LA. RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors. RNA Biol 2014 Jan;11(1):33-41. doi: 10.4161/rna.27427. Epub 2013 Dec 20.
  • Gane EJ, Deray G, Liaw YF, Lim SG, Lai CL, Rasenack J, Wang Y, Papaptheodoridis G, Di Bisceglie A, Buti M, Samuel D, Uddin A, Bosset S, Trylesinski A. Telbivudine Improves Renal Function in Patients with Chronic Hepatitis B. Gastroenterology. 2014 Jan;146(1):138-146. doi: 10.1053/j.gastro.2013.09.031. Epub 2013 Sep 22.
  • Tan AT, Hoang LT, Chin D, Rasmussen E, Lopatin U, Hart S, Bitter H, Chu T, Gruenbaum L, Ravindran P, Zhong H, Gane E, Lim SG, Chow WC, Chen PJ, Petric R, Bertoletti A, Hibberd ML. Reduction of HBV replication prolongs the early immunological response to IFNα therapy. J Hepatol. 2014 Jan;60(1):54-61. doi: 10.1016/j.jhep.2013.08.020. Epub 2013 Aug 29.
  • Venkatesh SK, Wang G, Lim SG, Wee A. Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B. Eur Radiol. 2014 Jan;24(1):70-8. doi: 10.1007/s00330-013-2978-8. Epub 2013 Aug 9.
  • Gehring AJ, Haniffa M, Kennedy PT, Ho ZZ, Boni C, Shin A, Banu N, Chia A, Lim SG, Ferrari C, Ginhoux F, Bertoletti A. Mobilizing monocytes to cross-present circulating viral antigen in chronic infection. J Clin Invest. 2013 Sep 3;123(9):3766-76. doi: 10.1172/JCI66043. Epub 2013 Aug 1.
  • Hartono JL, Aung MO, Dan YY, Gowans M, Lim K, Lee YM, Lee GH, Low HC, Tan PS, Thwin MA, Soon C, Chiu LL, Khoo MJ, Koay E, Lim SG. Resolution of adefovir-related nephrotoxicity by adefovir dose-reduction in patients with chronic hepatitis B. Aliment Pharmacol Ther. 2013 Apr;37(7):710-9. doi: 10.1111/apt.12251. Epub 2013 Feb 21.