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Prof Lee Yung Seng

Photo of Prof Lee Yung Seng
MBBS (S'pore), MMed (Paeds) (S'pore), MRCP (UK), FRCPCH (UK), FAMS (Paeds) S'pore), PhD
Head, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital
Senior Consultant, Division of Paediatric Endocrinology, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital

Chair, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital

Head of Department and Professor, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (Research Specialty: Endocrinology, Obesity)

Sub Specialty:
Paediatric Endocrinology
Medical and Surgical Conditions:
Congenital Hypothyroidism (Children), Disorders of Sex Development (Children), Graves' Disease (Children), Growth Disorders in Children, Obesity (Children), Osteoporosis (Children), Pubertal Disorders in Children, Turner Syndrome (Children), Type 1 and Type 2 Diabetes Mellitus (Children)
Special Interest:
  • Monogenic forms of childhood obesity
  • Complications of childhood obesity
  • Asian phenotype of childhood obesity
  • Developmental origins of health and disease
National University Hospital
National University Health System
Professor Lee Yung Seng is the head of the Department of Paediatrics with clinical interests in endocrinology and diabetes. He looks after children with problems in growth, puberty and hormonal abnormalities such as diabetes. A medical graduate of the National University of Singapore (NUS), Prof Lee is now a tenured faculty member of his alma mater, the Yong Loo Lin School of Medicine, NUS. He received his clinical training at NUH and specialist training in clinical paediatric endocrinology at the Cambridge University Department of Paediatrics at Addenbrooke's Hospital as well as research training at the University of Cambridge.

Prof Lee was awarded the NUH Young Doctor Award in 2002, the Young Researcher Award at the 12th National Congress of Child Health and 11th ASEAN Paediatric Federation Conference in 2002, the Young Investigator Award at the 12th Congress of ASEAN Federation of Endocrine Societies in 2003 and the Biomedical Research Council-National Medical Research Council Clinician Scientist Investigator Award in 2006.

  • 5 Feb 2015 – 5 Feb 2018: Whole-exome sequencing to identify genetic variants associated with severe childhood obesity, and tracking the changing prevalence of obesity related complications
    • Funding Agency: National Medical Research Council Clinician Scientist-Individual Research Grant

Awards and Honours

  • NMRC-BMRC Clinician Scientist Investigator Award (junior category) Feb 2006
  • Young Investigator Award, 12th Congress of ASEAN federation of Endocrine Societies, Singapore, 30 Nov – 4 Dec 2003
  • NUH Young Doctor Award, 6th National University of Singapore - National University Hospital Annual Scientific Meeting, 16th -– 17th Aug 2002 
  • Young Researcher Award, 12th National Congress of Child Health and 11th ASEAN Pediatric Federation Conference, Bali, Indonesia, 1 -– 4 Jul 2002
  • Merit Award – Young Doctor Award Competition, 4th National University Hospital-Faculty of Medicine, National University of Singapore Scientific Meeting, 30 June & 1 July 2000
  • A*STAR National Science Scholarships International Fellowship Award April 2003
  • NUH Citation award for research excellence 12 Dec 2003.

Research and Publications

  1. Lee YS, Challis B, Thompson D, Yeo G, Keogh J, Madonna M, . . . Farooqi IS (2006). A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metabolism, 3(2):135-40. doi: 10.1016/j.cmet.2006.01.006

  2. Lee YS, Poh LKS, Kek BLK, Loke KY (2007). The role of melanocortin 3 receptor gene in childhood obesity. Diabetes, 56(10):2622-30. doi: 10.2337/db07-0225

  3. Aris IM, Soh SE, Tint MT, Saw SM, Rajadurai VS, Godfrey KM, . . . Lee YS (2015). Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population. The American Journal of Clinical Nutrition, 102(5):1104-12. doi: 10.3945/ajcn.115.117614 

  4. Tan KML, Ooi SQ, SG Ong, CS Kwan, Chan RME, Poh LKS, . . . Lee YS (2014). Functional characterization of variants in MC4R gene promoter region found in obese children. The Journal of Clinical Endocrinology & Metabolism, 99(5): e931-5. doi: 10.1210/jc.2013-3711 

  5. Lee YS, Low SL, Lim LA, Loke KY (2001). Cyclic pamidronate infusion improves bone mineralisation and reduces fracture incidence in osteogenesis imperfecta. European Journal of Pediatrics, 160: 641-4.




Appt Tel:
+65 6779 7486