Skip Ribbon Commands
Skip to main content

Find a Doctor

Dr Lee Guan Huei

Photo of Dr Lee Guan Huei
  • Head of Division & Senior Consultant, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
  • Senior Consultant, Liver Transplantation, National University Centre for Organ Transplantation, National University Hospital
  • Medical Director, Adult Liver Transplantation Programme, National University Centre for Organ Transplantation, NUH
  • Research Director, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
MBBS (S'pore), MRCP (UK), FRCP Ed (UK), Ph.D. (S'pore)
Medicine, Organ Transplantation
Gastroenterology & Hepatology, Liver Transplantation
Special Interests:
Hepatitis B , Hepatitis C , Viral Hepatitis and Liver cancer , Liver Failure , Liver Transplantation , Hepatitis B Pathogenesis and Therapy, Non-Alcoholic Fatty Liver Disease, , Hepatocellular Carcinoma, Liver Failure and Transplantation


Dr Guan-Huei Lee graduated from the National University of Singapore (NUS) in 1999, passed the MRCP (UK) examination in 2004, and completed his advance specialist training in Gastroenterology in 2009. He worked as an associate consultant between 2009 and 2011 and was promoted to consultant in January 2012. He served as a clinical fellow at the Institute of Liver Studies, King’s College Hospital, London (2010-2011), focusing on liver intensive care.

Since returning to Singapore, Dr Lee has helped to strengthen the clinical capabilities of the Division of Gastroenterology & Hepatology, National University Hospital, in particular the area of viral hepatitis and the liver transplantation services. He was responsible for establishing the acute liver failure management protocol for the National University Centre for Organ Transplantation. He is also one of the members of the Asia Pacific Association for the Study of the Liver (APASL) Acute-on-chronic Liver Failure (ACLF) Research Consortium, and participated in the development of its latest consensus guideline for better management of ACLF for the diverse patients of the Asia Pacific.

Dr Lee is an assistant professor of the Department of Medicine, Yong Loo Lin School of Medicine (NUS). He lectures and tutors medical and nursing students, and undertakes postgraduate teaching and organises seminars for several key topics in gastroenterology. He was recently awarded the University Medicine Cluster Teaching Award. He was a faculty member and invited speaker at various local and regional meetings including the APASL Liver Week and GI-Hep Meeting Singapore.

Dr Lee received his PhD from NUS for his original work on “Hepatitis B pregenomic RNA splicing and its role in viral persistence”. He has been the research director for the gastroenterology division since 2013, with the responsibility of driving the division’s research activities. He started a new programme to introduce basic molecular biology laboratory training to gastroenterology trainees. He has had multiple publications in international peer-reviewed journals so far and has received research grants of over half a million dollars. He has presented at many major international conferences and received a number of scientific awards.

Personal Hobbies and Interests
Long-standing passion in tennis and reading history


National Medical Research Council, Medical Research Fellowship 2006-2009
Best Free Paper: GIHep Meeting 2008, Gastroenterological Society of Singapore
Singapore Clinician-Investigator Bronze Award - Singapore Health and Biomedical Congress 2010
Best Poster Award - GIHep Meeting 2013 by Gastroenterological Society of Singapore
Excellent Service Awards (Silver)
NUS Leadership in Academic Medicine Award
University Medicine Cluster (UMC) Teaching Award

Journals & Publications

  • Lee GH, Wasser S, Lim SG. Hepatitis B pregenomic RNA splicing--the products, the regulatory mechanisms and its biological significance. Virus Res. 2008 Sep;136(1-2):1-7.
  • Tan HH, Lee GH, Thia KTJ, Tan IK, Ng HS, WC Chow, Lui HF. Minimal Hepatic Encephalopathy Runs a Fluctuating Course: Results from a 3-Year Prospective Cohort Follow-Up Study. – Singapore Medical Journal 2009; 50 (3) : 255 
  • Lim LG, Aung MO, Seet BL, Tan C, Dan YY, Lee YM, Sutedja DS, Fernandes M, Lee GH, Koay E, Lim SG. Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance. World J Gastroenterol. 2010 Oct7;16(37):4691-6.
  • Lim SG, Aung MO, Mak B, Sutedja D, Lee YM, Lee GH, Fernandes M, Low HC, Lai V, Dan YY. Clinical outcomes of Lamivudine-adefovir therapy in chronic hepatitis B cirrhosis. J Clin Gastroenterol. 2011 Oct;45(9):818-23.
  • Guan Huei Lee, Myat Oo Aung, Yock Young Dan, Yin Mei Lee, Belinda Mak, Seng Gee Lim. Do Different Lamivudine-ResistantHepatitis B Genotypes Carry the Same Risk of Entecavir Resistance?J Med Virol. 2013 Jan;85(1):26-33.
  • Tan PS, Aung MO, Dan YY, Lee YM, Lim K, Low HC, Lee GH, Thwin MA, Soon C, Lim SG. Liver disease progression and virological response: entecavir rescue still possible in the setting of rtM204I lamivudine-resistant mutation. Gut 2013 May;62(5):801-2. 
  • Guan-Huei Lee, Masafumi Inoue, Jimmy Kim-Pern Toh, Roxanne Hui-Heng Chong, Myat-Oo Aung, Seng-Gee Lim.Two-Step Evolution of the Hepatitis B Drug-Resistant Mutations in a Patient who Developed Primary Entecavir Resistance.Liver International 2013 Jan 24.
  • Seng Gee Lim, Guan Huei Lee, Kieron Lim, Poh Seng Tan. Resistance is No Longer a Problem with Entecavir and Tenofovir. Current Hepatitis Reports 2013 Jun 1(12):96-104.
  • Juanda Leo Hartono, Myat Oo Aung, Yock Young Dan, Michelle Gowans, Kieron Lim, Yin Mei Lee, Guan Huei Lee, How Cheng Low, Belinda Mak, Maung Aye Thwin, Lily- Lily Chiu, Mui Joo Khoo, Evelyn Koay, Seng Gee Lim. Resolution of Adefovir-related nephrotoxicity by Adefovir dose reduction in patients with chronic hepatitis B. Alimentary Pharmacology & Therapeutics 2013 Apr;37(7):710-9.
  • Mark JW McPhail, Debbie L Shawcross, Robin D Abeles, Anthony Chang, Vishal Patel, Guan-Huei Lee, Maheeba Abdulla, Elizabeth Sizer, Christopher Willars, Georg Auzinger, William Bernal and Julia A Wendon. Improving survival and predicting outcome in patients with cirrhosis with organ failure: a decade of experience in liver intensive care. Clin Gastroenterol Hepatol. 2014.

Professional Memberships


Royal College of Physicians and Surgeons of Glasgow
Asia Pacific Association for the Study of Liver Disease
APASL ACLF Research Consortium
HepatoPancreatoBiliary Association (Singapore)
Gastroenteroloy Society of Singapore