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Dr Jonathan Lee Wei Jie

  • Consultant, Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital
BSc Hons (UNSW, Australia), MBBS Hons (UNSW, Australia), MRCP (UK), MCI (NUS, Singapore), FAMS (Gastroenterology)
Gastroenterology & Hepatology
Special Interests:
​Gastroscopy and Colonoscopy, Gastrointestinal Cancer Screening, Inflammatory Bowel Disease, Fecal Microbiota Transplant


Dr Jonathan Lee is a Consultant specializing in Gastroenterology and Hepatology at National University Hospital, Singapore, as well as an Assistant Professor at NUS Yong Loo Lin School of Medicine. He currently services as the director of Research, for the divsion of Gastroenterology and Hepatology.

Dr Lee graduated from University of New South Wales, Australia, and did his postgraduate residency in NUH. He completed his fellowship in Gastroenterology and Hepatology and was certified by the Specialist Accreditation Board of Singapore in 2017. Following completion of specialist training, he completed an exchange fellowship at Kyushu University Hospital for imaged-enhanced endoscopy in 2018, and subsequently completed a two-year full-time overseas NRMC research training fellowship (2019-2021) at the Broad Institute, USA, under Prof Ramnik Xavier.

Dr Jonathan Lee has a keen interest in translational microbiome medicine, and drives the fecal microbiota transplant clinical service at the National University Hospital, Singapore. His research interest is in studying the role of microbiome associated with gastrointestinal diseases, whereby he previously used microbial metagenomics to prognosticate patients with inflammatory bowel disease and colorectal adenomatous polyps. He is currently a principle investigator for multiple ongoing basic and translational research in this field.

Journals & Publications

  • Tan, E. X. -X., Lee, J. W. -J., Jumat, N. H., Chan, W. -K., Treeprasertsuk, S., Goh, G. B. -B., . . . Dan, Y. -Y. (2021). Non-obese non-alcoholic fatty liver disease (NAFLD) in Asia: an international registry study.. Metabolism, 154911. doi:10.1016/j.metabol.2021.154911
  • Lee, J. W. J., Plichta, D., Hogstrom, L., Borren, N. Z., Lau, H., Gregory, S. M., . . . Ananthakrishnan, A. N. (2021). Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease. CELL HOST & MICROBE, 29(8), 1294-+. doi:10.1016/j.chom.2021.06.019
  • Deng, L., Tay, H., Peng, G., Lee, J. W. J., & Tan, K. S. W. (2021). Prevalence and molecular subtyping of Blastocystis in patients with Clostridium difficile infection, Singapore. PARASITES & VECTORS, 14(1), 9 pages. doi:10.1186/s13071-021-04749-8
  • So, J. B. Y., Kapoor, R., Zhu, F., Koh, C., Zhou, L., Zou, R., . . . Yeoh, K. -G. (2021).Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population. GUT, 70(5), 829-837. doi:10.1136/gutjnl-2020-322065
  • Tang, R. S. Y., Lee, J. W. J., Chang, L. C., Ong, D. E. H., Chiu, H. M., Matsuda, T., . . . Sung, J. J. Y. (2021). Two vs One Forward View Examination of Right Colon on Adenoma Detection: An International Multicenter Randomized Trial. Clinical Gastroenterology and Hepatology. doi:10.1016/j.cgh.2020.10.014
  • Lee, J. W. J., Zhu, F., Srivastava, S., Tsao, S. K. K., Khor, C., Ho, K. Y., . . . Yeoh, K. G. (2021). Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: A prospective multicentre cohort study (GCEP). Gut. doi:10.1136/gutjnl-2021-324057
  • Soh, Y. S. A., Ooi, S. Q. D., Chan, Y. H., Siah, T. -H. K., Lee, S. -E., Lee, W. J. J., . . . Gwee, K. -A. (2020). Rising prevalence of colonic diverticulosis in a westernized multi-ethnic Asian community. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 36(2), 413-420. doi:10.1111/jgh.15165
  • Koo, C. S., Wang, S., & Lee, J. W. J. (2020). Esophageal Melanocytosis in a Patient With Gastroesophagheal Reflux Disease. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 18(2), XVII-XVIII. doi:10.1016/j.cgh.2018.11.044
  • Koh, Z. J., Salgaonkar, H. P., Lee, W. J. J., Kim, G. W., Tan, C. H., Cheng, A., . . . Shabbir, A. (2019). Improvement in Non-alcoholic Fatty Liver Disease Score Correlates with Weight Loss in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: a Two-Centre Study from an Asian Cohort. OBESITY SURGERY, 29(3), 862-868. doi:10.1007/s11695-018-3581-5
  • Lee, J. W. J., Koh, C. J., & Ho, K. Y. (2019). Metabolic syndrome and gastrointestinal cancers. Indian Journal of Gastroenterology, 38(1), 3-5. doi:10.1007/s12664-019-00939-6


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