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Dr Anand Jeyasekharan

Photo of Dr Anand Jeyasekharan
Credential:
MBBS (CMC Vellore, India), MRCP (UK), PhD (Cantab), FAMS (Medical Oncology)
Designation:
Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore

Assistant Director of Research (Medical Oncology), Department of Haematology-Oncology, National University Hospital, Singapore
Principal Investigator and Facility Head (Microscopy), Cancer Science Institute
National University of Singapore
Assistant Professor; Department of Medicine, Yong Loo Lin School of Medicine, NUS

Specialty:
Cancer
Sub Specialty:
Haematology, Haematology-Oncology
Medical and Surgical Conditions:
Blood Cancer, Lymphoma
Special Interest:
Lymphomas
Targeting genomic instability in cancer
Institution:
National University Hospital
National University Cancer Institute, Singapore
National University Health System

Dr Jeyasekharan obtained his undergraduate medical degree from Christian Medical College Vellore, India in 2003. He then received a Gates Cambridge Scholarship towards a PhD in Oncology (2008) at the University of Cambridge UK (Gonville and Caius College), under the mentorship of Prof. Ashok Venkitaraman. Following a post-doctoral fellowship in Cambridge as a Junior Research Fellow (Wolfson), he joined the National University Hospital Singapore in 2010 to complete his training in Internal Medicine, and Medical Oncology (2016). He has been active in medical research at the NUHS, and holds a joint appointment at the Cancer Science Institute, where he has run a basic science laboratory since 2013. His laboratory focuses on understanding defects in DNA repair in tumours, and the development of biomarkers of these pathways for clinical use. Dr. Jeyasekharan holds multiple internal and nationally funded grants to support his research, and is also actively involved in the Clinician-Scientist Unit at the NUH, where he administers the National University Hospital Clinician-Scientist Program for Residents (NCSP-R). His clinical interest is in aggressive B-cell neoplasms, and he is a member of the NUH lymphoma team.

Awards and Honours

Gates Cambridge Scholarship (2005-2008): Gates Cambridge Trust, University of Cambridge, UK

Junior Research Fellowship (2009-10); Wolfson College, University of Cambridge, UK.

Academic Development Award (2011); National University Hospital, Singapore

NUHS Clinician-Scientist Program Award (2013); National University Hospital, Singapore

Clinician-Scientist Transition Award (2016); National Medical Research Council, Singapore

Professional Memberships

​Royal College of Physicians, London

Academy of Medicine, Singapore

Research and Publications

1. Hong G, Fan S, Phyu T, Maheshwari P, Hoppe MM, Phuong HM, de Mel S, Poon M, Ng SB, Jeyasekharan AD. Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma. J. Vis. Exp. 2019 (143), e58711, doi:10.3791/58711.

2. Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD. ROS and the DNA damage response in cancer. Redox Biol. 2018 Dec 21:101084. doi: 10.1016/j.redox.2018.101084. PMID: 30612957

3. Hoppe MM, Sundar R, Tan DSPJeyasekharan AD. Biomarkers for Homologous Recombination Deficiency in Cancer. J Natl Cancer Inst. 2018 July, 110(7):704-713; PMID:29788099.

4. Tay SHWong AS, Jeyasekharan AD. A patient with pembrolizumab-induced fatal polymyositis. Eur J Cancer. 2018 Jan, 91:180-182; PMID:29329695.

5. Ng SB, Fan S, Hoppe M, De Mel S, Jeyasekharan AD. Quantitative Analysis of a Multiplexed Immunofluorescence Panel in T-Cell Lymphoma. SLAS Technol 2017 Dec, PMID:29241019.

6. Ng SB, Chung TH, Kato S, Nakamura S, Takahashi E, Ko YH, Khoury JD, Yin CC, Soong R, Jeyasekharan AD, Hoppe MM, Selvarajan V, Tan SY, Lim ST, Ong CK, Nairismägi ML, Maheshwari P, Choo SN, Fan S, Lee CK, Chuang SS, Chng WJ. EBV-associated primary nodal T/NK-cell lymphoma shows distinct molecular signature and copy number changes. Haematologica 2017 Nov 2, 180430; PMID:29097495.

7. Sundar R, Jeyasekharan AD, Pang B, Soong R et al; Low levels of NDRG1 in nerve tissue are predictive of severe paclitaxel-induced neuropathy. PLoS One 2016 Oct 7;11(10):e0164319, PMID:27716814.

8. Roy RK, Hoppe MM, Srivastava S, Samanta A, Sharma N, Tan KT, Yang H, Voon DC, Pang B, Teh M, Murata-Kamiya N, Hatakeyama M, Chang YT, Yong WP, Ito Y, Ho KY, Tan P, Soong R, Koeffler PH, Yeoh KG, Jeyasekharan AD. CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer. Oncotarget. 2016 Aug 23:7(34):55290-55301, PMID:27421133.

9. Nagasawa S, Sedukhina AS, Nakagawa Y, Maeda I, Kubota M, Ohnuma S, Tsugawa K, Ohta T, Roche-Molina M, Bernal JA, Narváez AJ, Jeyasekharan AD, Sato K. LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition. PLoS One. 2015 Feb 13;10(2), PMID:25679396.

10. Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan AD, Ayoub N. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):E728-37, PMID: 24550317.

11. Jeyasekharan AD, Liu Y, Hattori H, Pisupati VN, Jonsdottir, Eeson Rajendra et al, and Venkitaraman AR. A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Nat Struct Mol Biol. 2013 Oct;20(10):1191-8, PMID:24013206.

12. Mahen R, Jeyasekharan AD, Barry N, Venkitaraman AR. Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis. Proc Natl Acad Sci USA. 2011 May 31;108(22):9310-5, PMID:21576470.

13. Jeyasekharan AD, Ayoub N, Ries J, Mahen R, Rajendra E, Kulkarni R, Venkitaraman AR. Regulation of Brca2 intranuclear mobility promotes its assembly on damaged DNA. Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21937-42, PMID:21098284.

14. Ayoub N*, Jeyasekharan AD*, Venkitaraman AR (*Equally contributed). Mobilization and recruitment of HP1; A bimodal response to DNA breakage. Cell Cycle. 2009 Sep 15;8(18):2945-50, PMID:19657222.

15. Ayoub N, Jeyasekharan AD, Bernal JA, Venkitaraman AR. HP1 mobilization promotes chromatin changes that initiate the DNA damage response. Nature. 2008 May 29;453(7195):682-6, PMID:18438399.


Contact

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+65 6777 4413