Cerebrovascular Disease & Stroke Genetic Disorders
2026/03/30
Cerebrovascular diseases affect the blood vessels that supply the brain. These include conditions such as ischaemic stroke, intracerebral haemorrhage, and disorders involving the brain’s arteries and veins. A stroke happens when blood flow to part of the brain is interrupted, leading to brain injury and neurological symptoms.
While many strokes are linked to common factors like high blood pressure, diabetes or smoking, some individuals, especially younger adults or those with a strong family history, may have an underlying genetic cause. With advances in genomic medicine, we can now better identify inherited contributors to cerebrovascular disease and tailor care more precisely.
We offer a comprehensive and integrated approach that includes:
- Specialist assessment for cerebrovascular and stroke‑related genetic conditions
- Detailed review of brain and vascular imaging
- Pre‑test and post‑test genetic counselling
- Interpretation of genetic results with clinical correlation
- Individualised management plans and recommendations for secondary stroke prevention
- Advice and support for family screening and cascade testing
- Coordination with stroke rehabilitation and related services
Genetic testing can provide clarity and support your long‑term care by:
- Identifying inherited causes of stroke that standard tests may not detect
- Improving diagnostic accuracy in unexplained or atypical stroke
- Helping personalise your risk assessment for future cerebrovascular events
- Informing screening and guidance for family members who may be at risk
- Supporting long‑term management, secondary prevention, and brain health planning
Genetic results are always interpreted together with clinical assessment, imaging, and other investigations.
Depending on your clinical needs, testing may include:
- Targeted gene panels for inherited cerebrovascular disorders
- Whole‑exome or whole‑genome–based testing when appropriate
- Assessment of rare or uncertain genetic variants linked to stroke risk
- Specialised or confirmatory tests, where indicated
All testing strategies are personalised and discussed with you before proceeding.
Adults may benefit from specialist evaluation for genetic causes of cerebrovascular disease if they have:
- Stroke at a young age (typically before 50 years)
- Recurrent strokes or transient ischaemic attacks without a clear cause
- Unusual stroke types, such as arterial dissections or early‑onset small vessel disease
- A family history of stroke or related neurological conditions
- Brain imaging features suggestive of hereditary vascular disorders
Referrals are welcome for both newly diagnosed patients and those seeking further evaluation of unexplained, atypical, or familial cerebrovascular disease.
Neuroscience Clinic
National University Hospital
Kent Ridge Wing, Level 4
5 Lower Kent Ridge Road
Singapore 119074
Opening Hours
Monday – Friday: 8.00am–5.30pm
Closed on Saturdays, Sundays & Public Holidays
