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Dr Shawn Lee

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  • Consultant, Division of Paediatric Haematology and Oncology, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital


MBBS (S'pore), MMed (Paeds) (S'pore), MRCPCH (UK), MCI (S'pore)


Paediatric Haematology & Oncology, Paediatric Medicine

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Dr Shawn Lee graduated with MBBS from Yong Loo Lin School of Medicine, NUS in 2011 where he was awarded the Wong Poi Kwong Medal for Clinical Medicine. He went on to obtain his Master of Medicine (Paeds) and MRCPCH (UK) in 2015 and begun subspecialty training in paediatric haematology-oncology. In 2017, he was awarded the Exxon-Mobil Fellowship for Clinicians. During his senior residency in 2017, he served a leadership role of Assistant Chief Registrar. He completed his senior residency and obtained specialist accreditation in Paediatric Medicine in 2019. 

Dr Lee has been awarded the NMRC Research Training Fellowship in 2019, where he will embark on a 2-year fellowship in pharmacogenomics and immunogenomics under Dr Yang Jun in St. Jude Children's Research Hospital in Memphis, USA. His specialty clinical interests are in the areas of childhood leukaemia and lymphoma as well as the toxicities associated with treatment such as neutropenic fever. His research interests include immunotherapy and immunogenomics to aid in prognostication, risk stratification and optimal utilisation of immunotherapeutic agents. He is also invested in individualised therapy in oncology, specifically pharmacogenomics to evaluate drug resistance mechanisms in leukaemia and allow for personalised tailoring of treatment therapy.


  • 2018 - NUHkids Junior Research Award (Highest Grants)
  • 2018 - Merit Award, NUHS Clinician Scientist Unit Pitch For Funds Rounds
  • 2018 - ExxonMobil-NUS Research Fellowship For Clinicians
  • 2018 - National Medical Research Council (NMRC) Research Training Fellowship
  • 2018 - Best Oral Presentation, NUHS Clinician Scientist Program Residency
  • 2017 - MOH Healthcare Research Scholarship: Master of Clinical Investigation
  • 2017 - Best Oral Presentation, NUHS Clinician Scientist Program Residency

Journals & Publications

  1. Association of Genetic Ancestry with the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia,Shawn Lee, Federico Antillon, Deqing Pei, et al, .JAMA Oncol. Published online January 27, 2022. doi:10.1001/jamaoncol.2021.6826
  2.  Genetic alterations in childhood acute lymphoblastic leukemia: interactions with clinical features and treatment response, Shawn Lee, Zhenhua Li, Si Ting Tai, Bernice LZ Oh, and Allen EJ Yeoh, Cancers, 2021, 13, 4068.
  3. Distinct clinical characteristics of DUX4 and PAX5 altered childhood B-lymphoblastic leukemia, Zhenhua Li, Shawn Lee, Winnie Chin, et al. Blood Adv. 2021 Dec 14;5(23):5226-5238. doi: 10.1182/bloodadvances.2021004895.
  4. 4Successful toxicity reduction during delayed intensification in the non-high-risk arm of Malaysia-Singapore Acute Lymphoblastic Leukaemia 2010 study. Oh BLZ, Shawn Lee, Foo KM, et al. Eur J Cancer. 2021 Jan;142:92-101. doi: 10.1016/j.ejca.2020.10.010. 
  5. Genome-wide association study of susceptibility loci for TCF3-PBX1 acute lymphoblastic leukemia in children. Shawn Lee, Qian M, Yang W, et al.bJ Natl Cancer Inst. 2020 Sep 3:djaa133. doi: 10.1093/jnci/djaa133.
  6. Epidemiology of Childhood Malignant Mediastinal Masses and Clinical Factors Associated With Intensive Care Unit Admission: A Singapore Experience. Shawn Lee, Bernice Oh, Miriam Kimpo, TC Quah, Journal of Pediatrics and Child Health, 2019 (in publication)
  7. The Role of NK Cells as A Platform for Immunotherapy in Pediatric Cancers. Miriam Kimpo, Bernice Oh, Shawn Lee, Current Oncology Reports, Curr Oncol Rep. 2019; 21(10): 93.
  8. Pharmacogenomics in Acute Lymphoblastic Leukemia. Shawn Lee, Jun J Yang, Best Practice & Research Clinical Hematology, July 2017, DOI:
  9. Acronyms in Ophthalmology. Shawn Lee, Woo Jyh Haur, Au-Eong KG, Ophthalmology, Volume 119, Issue 9 , Pages 1939. 1940.e1, September 2012

Professional Memberships

  • Member, Paediatric Oncology Group Singapore (Executive committee, 2017)
  • Member, International Society of Paediatric Oncology (SIOP)
  • International Associate Member, American Society of Hematology
  • Member, Royal College of Paediatrics and Child Health
  • Member, Pharmacogenomics Global Research Network (PGRN)
  • Member, American Association for Cancer Research (AACR)
  • Member, Society of Hematology-Oncology
  • Member, Singapore Medical Association

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