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Dr Robert Grignani

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  • Consultant, Division of Paediatric Cardiology, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital
  • Assistant Professor, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (S'pore), MRCPCH (Paeds) (UK), Specialist Board Accreditation in Paediatric Cardiology, Specialist Board Accreditation in Paediatric Medicine, D.Phil (University of Oxford)


Paediatric Medicine

Clinical Disciplines/Programmes:

Paediatric Cardiology (Heart Conditions)

Special Interests:

Exercise induced cardiac remodelling, Kawasaki Disease, Congenital heart disease, Clinical exercise testing, Genetics of inherited cardiac conditions

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Dr Robert Grignani is a consultant at the Division of Paediatric Cardiology, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, and Assistant Professor at the National University of Singapore, and Clinical Investigator at the National University Health System.

Dr Grignani was awarded a full Medical and Doctorate scholarship from the National University of Singapore and Agency for Science, Technology and Research in 2002. He read for his Doctorate in Medicine in 2005 at the University of Oxford after which he graduated with MBBS from the National University of Singapore in 2008. He trained in Paediatrics at the National University Hospital of Singapore and became a Member for the Royal College of Paediatrics and Child Health (United Kingdom) inĀ 2011, and subsequently received specialist accreditation in Paediatric Medicine in 2015. He completed his subspecialty training in Paediatric Cardiology at the Division of Paediatric Cardiology, National University Hospital of Singapore and received his specialist accreditation in Paediatric Cardiology in 2017.

His clinical interests include congenital heart disease, Kawasaki disease, paediatric exercise cardiology and interventional cardiology. He has a keen interest in clinical and translational research and is passionate about teaching the future generations of young doctors.

Journals & Publications

  1. Grignani R, Rajgor DD, Leow YG, Henf CK, Quek SC. A Novel Model for Predicting Non-Responsiveness to Intravenous Immunoglobulins in Kawasaki Disease: The Singapore experience. 2019 Aug;55(8):962-967.
  2. Grignani R, Quek SC. Kawaski Disease in 2019 – Past Controversies, Present Insights and Future Directions. Pediatr Med 2019;2:10.
  3. Quek SC, Santos D, Rajgo D, Grignani R. Comparison of Ouctomes and Costs of Transcatheter Therapeutic Intervention and Surgical Ligation for the Treatment of Patent Ductus Arteriosus. Ann Acad Med Singapore. 2016 Jun;45(6):256-8.
  4. Lim TS, Grignani RT, Tambyah PA, Quek SC. Impact of dengue-induced thrombocytopenia on mandatory anticoagulation for patients with prosthetic heart valves on warfarin. Singapore Med J. 2015 Apr;56(4):235-6.
  5. Grignani RT, Tolentino KM, Rajgor DD, Quek SC. Longitudinal Evaluation of P-Wave Dispersion and P-Wave Maximum in Children After Transcatheter Device Closure of Secundum Atrial Septal Defect. Pediatr Cardiol. 2015 Jan 28
  6. Pinter K, Grignani RT, Watkins H, Redwood C. Localisation of AMPK γ subunits in cardiac and skeletal muscles. J Muscle Res Cell Motil. 2013 Dec;34(5-6):369-78.
  7. Grignani RT, Pinter K, Czibik G, Farza H, Watkins H, Redwood C. Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart. J Mol Cell Cardiol. 2012 Sep;53(3):342-9.
  8. Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Walley AJ, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Williams TN, Davies RJO, Kwiatkowski DP, Day NP, Crook DW, Marsh K, Berkley JA, O'Neill JAJ, Hill AVS. A Functional Variant in MAL/TIRAP Associates with Protection Against Invasive Pneumococcal Disease, Bacteraemia, Malaria, and Tuberculosis in Different Human Populations. Nat Genet. 2007 Apr;39(4):523-8.
  9. Lim ER, Carballo S, Cornelissen J, Ali ZA, Grignani R, Bellm S,Large S.Dose-related efficacy of aspirin after coronary surgery in patients With Pl(A2) polymorphism (NCT00262275). Annals of  Thoracic Surgery. 2007 Jan;83(1):134-8.
  10. Grignani R, Pinter K, Farza H, Carballo S, Oliviera M, Redwood C, Blair E, Watkins H. Delineating the Role of Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) γ2 Subunit in Hypertrophic Cardiomyopathy. Heart. 2005 May; 91(Supp I):A69-A70.

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