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Doctor Details

2024/01/25
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A/Prof Ng Kar Hui

Photo of A/Prof Ng Kar Hui

Designations:

  • Senior Consultant, Division of Paediatric Nephrology, Dialysis and Renal Transplantation, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital
  • Senior Consultant, Division of Genetics and Metabolism, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital
  • Senior Consultant, Paediatric Kidney Transplantation Programme, National University Centre for Organ Transplantation, National University Hospital
  • Associate Professor, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
  • Director, National University Centre for Genomic Medicine, National University Hospital

Qualifications:

MBBS (S'pore), MMed (Paeds) (S'pore), MRCPCH (UK), FRCPCH (UK), FAMS (Paeds) (S’pore)

Specialties/Sub-specialties:

Paediatric Medicine

Clinical Disciplines/Programmes:

Organ Transplantation, Paediatric Kidney Transplantation Programme, Paediatric Nephrology, Dialysis & Renal Transplantation (Kidney, Bladder & Urine Conditions)

Biosketch

A/Prof Ng Kar Hui is a paediatric nephrologist and clinical academic whose work bridges kidney medicine and genomics. She obtained her Master of Medicine (Paediatrics) and is a Fellow of the Royal College of Paediatrics and Child Health (UK). She is accredited by the Ministry of Health, Singapore, as a specialist in Paediatric Medicine and Paediatric Nephrology. Her clinical practice spans the full spectrum of paediatric nephrology, including dialysis and kidney transplantation. She has interests in genetic kidney diseases and dialysis in young children, and cares for patients in the Kidney Genetics Clinic as well as expectant couples in the Fetal Kidney Clinic.

Following a two-year research fellowship at Boston Children’s Hospital, supported by the Singapore National Medical Research Council, A/Prof Ng established one of Singapore’s earliest research programmes on the genetics of kidney disease. She founded the DRAGoN (Deciphering Diversities: Renal Asian Genetics Network) collaborative network to study genetic kidney disorders across South Asia, and has served as Principal Investigator on multiple nationally competitive grants, including the Clinician Scientist Award. She also founded and leads the Renal Alliance for PrecIsion Diagnosis in Singapore (RAPIDS), a multi-institutional, multidisciplinary consortium of kidney and genomics experts focused on implementing genomic medicine in routine kidney care.

A/Prof Ng is a Subject Editor for the journal Nephrology and has authored numerous peer reviewed publications and book chapters. She is frequently invited to speak at international medical conferences. As an Education Ambassador for the International Society of Nephrology, she regularly teaches paediatric nephrology in under resourced settings across Asia.

A dedicated educator, she teaches paediatrics and nephrology to medical students and trainees, and is a two-time recipient of the NUS Faculty Teaching Excellence Award. She currently serves on the Paediatric Medicine Resident Advisory Committee and the Clinical Ethics Committee at NUH, and leads efforts in the clinical implementation of genomic medicine across the National University Health System.

She now serves as Director of the National University Centre for Genomic Medicine (NUGEM), where she is responsible for advancing genomics and precision medicine to benefit patients and families across NUHS.

Awards

  • 2017 - Faculty Teaching Excellence Award for academic years 2015/2016, NUS
  • 2021 - Young Investigator Award, 14th Asian Congress of Pediatric Nephrology, Taiwan

Journals & Publications

  1. Gunasekara WD, Ng KH, Chan YH, Aragon E, Foong PP, Lau YW, . . . Yap HK (2010). Specialist pediatric dialysis nursing improves outcomes in children on chronic peritoneal dialysis. Pediatric Nephrology (Berlin, Germany), 25(10):2141-7. doi: 10.1007/s00467-010-1581-3
  2. Sathe KP, Yeo WS, Liu ID, Ekambaram S, Azar M, Yap HK, Ng KH (2015). Recurrent white thrombi formation in hemodialysis tubing: a case report. BMC Nephrology, 16:3. doi: 10.1186/1471-2369-16-3
  3. Sun ZJ, Ng KH, Liao P, Zhang Y, Ng JL, Liu ID, . . . Yap HK (2015). Genetic Interactions Between TRPC6 and NPHS1 Variants Affect Posttransplant Risk of Recurrent Focal Segmental Glomerulosclerosis. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(12):3229-38. doi: 10.1111/ajt.13378
  4. Chaturvedi S, Ng KH, Mammen C. The path to chronic kidney disease following acute kidney injury: a neonatal perspective. Pediatric Nephrology (Berlin, Germany), 32(2):227-241. doi: 10.1007/s00467-015-3298-9
  5. Chan CY, Ng KH, Chen J, Lu J, Lee CG, Tan PH, …Yap HK (2016). Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in Interleukin-13-induced minimal change-like nephropathy. Clinical Science (London, England : 1979). doi:10.1042/CS20160312.
  6. Ng KH, Zhang SL, Tan HC, Kwek SS, Sessions OM, Chan CY, Liu ID, Lee CK, Tambyah PA, Ooi EE, Yap HK. Persistent Dengue Infection in an Immunosuppressed Patient Reveals the Roles of Humoral and Cellular Immune Responses in Virus Clearance. Cell Host Microbe. 2019 Nov 13;26(5):601-605.e3. doi: 10.1016/j.chom.2019.10.005. Epub 2019 Oct 29.
  7. Sharon Teo, Tin Wei Yuen, Clarissa Wei-Shuen Cheong, … Hui-Kim Yap, Kar-Hui Ng. Structured Re-training to Reduce Peritonitis in a Pediatric Peritoneal Dialysis Program: A Quality Improvement Intervention. Paediatric Nephrology, 2021, in press

2026/05/07
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