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Prof Lim Seng Gee

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  • Senior Consultant, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
  • Senior Consultant, Adult Liver Transplantation Programme, National University Centre for Organ Transplantation, National University Hospital
  • Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (Hons Monash), FRACP (Aust), FRCP (London), MD (Monash), FAMS (S'pore), Cert Immunology (King's College)



Clinical Disciplines/Programmes:

Adult Liver Transplantation Programme, Gastroenterology & Hepatology, Medicine, Organ Transplantation

Special Interests:

Viral Hepatitis, Liver cirrhosis, Liver cancer, Liver disease, Liver Failure, Liver transplantation


Prof Lim Seng Gee currently serves as a Senior Consultant and Director of Hepatology at the Division of Gastroenterology and Hepatology, and a Senior Consultant at the Adult Liver Transplantation Programme, National University Centre for Organ Transplantation in National University Hospital, Singapore. He is an expert panel member, Centre for Drug Administration (CPA) and Centre for Drug Evaluation (CDE) at the Ministry of Health, Singapore and the Chairman of Singapore Hepatitis Conference since 2014. He is also a Professor in the Yong Loo Lin School of Medicine, National University of Singapore.
Prof Lim attained his basic medical degree with honours (MBBS Hons) from the University of Monash, Melbourne, Australia. He later pursued a doctorate degree (MD) in Monash and was awarded the FRACP (Australia), FRCP (London), FAMS (Gasteroenterology, Singapore).
He is considered a master clinician having trained over 40 gastroenterologists and hepatologists, and is regularly referred difficult to treat liver cases. His main clinical work focuses on the treatment of viral hepatitis (esp. B and C), liver disease and liver cancer.
Prof Lim's research activities include leadership in Hepatology research, which focuses on improving treatment for chronic hepatitis B and C, pathophysiology of hepatitis B disease, HBV virology, immunological mechanisms of HBeAg seroconversion, and loss of immune tolerance to hepatitis B virus. He also has an interest in pathophysiology and treatment of liver cancer, primary hepatocyte culture, hepatocyte function, drug related liver disease and non-alcoholic fatty liver disease.
Prof Lim has over 253 publications in peer-reviewed journals with a H-index of 51, and sits on the editorial board of Liver International Hepatology, International, J Viral Hepatitis, Alimentary Pharmacology and Therapeutics, and Lancet Gastroenterology and Hepatology. He has received over S$48 million in research grants.
Prof Lim also sits on the Advisory Board of Novartis Pharmaceuticals, Idenix Pharmaceuticals, Bristol Myers Squibb Pharmaceuticals and is on the Speaker's Bureau for GlaxoSmithKline and Schering Plough Pharmaceuticals. Prof Lim has been an invited speaker at AASLD, EASL and APASL in 2013, 2014 and is a regular speaker at numerous International and Regional meetings on liver disease and viral hepatitis.
Prof Lim is also an Evidence Based Medicine (EBM) Champion, having founded the annual Asia Pacific EBM workshop in 2004 together with Prof Tony Dans from the Philippines which still runs yearly, and actively teaches and contributes to the development of EBM in Singapore.
Prof Lim is Council member, International Coaliltion for Eradication of Hepatitis B Virus (ICE-HBV), AASLD Asia Pacific Regional Council member, Co-chair ICE-HBV treatment subcommittee, and Co-chair combination therapy subcommittee HBV Forum.


  • 2016 - Blumberg Oration
  • 2017 - Clinician Scientist Award Senior Category

Journals & Publications

  1. Feld J, Janssen HL, Abbas Z, Elewaut A, Ferenci P, Isakov V, Khan AG, Lim SG, Locarnini SA, Ono SK, Sollano J, Spearman CW, Yeh CT, Yuen MF, LeMair A; Review Team. World Gastroenterology Organisation Global Guideline Hepatitis B: September 2015. J Clin Gastroenterol. 2016 Oct;50(9):691-703.
  2. Seng Gee Lim, Alessio Aghemo, Pei-Jer Chen, Yock Young Dan, Edward Gane, Rino Gani, Robert G Gish, Richard Guan, Ji Dong Jia, Kieron Lim, Teerha Piratvisuth, Samir Shah, Mitchell L Shiffman, Frank Tacke, Soek Siam Tan, Tawesak Tanwandee, Khin Maung Win, Cihan Yurdaydin. Management of hepatitis C virus infection in the Asia-Pacific region: an update. Lancet Gastroenterol Hepatol 2017; 2: 52–62.
  3. Chong CH, Lim SG. When can we stop nucleoside analogues in patients with chronic hepatitis B? Liver Int. 2017 Jan;37 Suppl 1:52-58. doi: 10.1111/liv.13314. Review.
  4. Lim SG. HCV management in resource-constrained countries. Hepatol Int. 2017 May;11(3):245-254. doi: 10.1007/s12072-017-9787-0. Epub 2017 Feb 21. Review.
  5. Anderson RT, Lim SG, Mishra P, Josephson F, Donaldson E, Given B, Miller V. Challenges, Considerations, and Principles to Guide Trials of Combination Therapies for Chronic HBV. Gastroenterology. 2018 Dec 4. pii: S0016-5085(18)35378-2. doi: 10.1053/j.gastro.2018.11.062. [Epub ahead of print].
  6. Revill PA, Chisari FV, Block JM, Dandri M, Gehring AJ, Guo H, Hu J, Kramvis A, Lampertico P, Janssen HLA, Levrero M, Li W, Liang TJ, Lim SG, Lu F, Penicaud MC, Tavis JE, Thimme R; Members of the ICE-HBV Working Groups; ICE-HBV Stakeholders Group Chairs; ICE-HBV Senior Advisors, Zoulim F.A global scientific strategy to cure hepatitis B. Lancet Gastroenterol Hepatol. 2019 Jul;4(7):545-558. doi: 10.1016/S2468-1253(19)30119-0. Epub 2019 Apr 10. Erratum in: Lancet Gastroenterol Hepatol. 2019 Jul;4(7):e7.
  7. Lim SG, Agcaoili J, De Souza NNA, Chan E. Therapeutic vaccination for chronic hepatitis B: A systematic review and meta-analysis. J Viral Hepat. 2019 Jul;26(7):803-817.
  8. Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, Jia J, Tian Q, Aggarwal R, Muljono DH, Omata M, Ooka Y, Han KH, Lee HW, Jafri W, Butt AS, Chong CH, Lim SG, Pwu RF, Chen DS. Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastroenterol Hepatol. 2020 Feb;5(2):167-228.
  9. Fonseca MA, Ling JZJ, Al-Siyabi O, Co-Tanko V, Chan E, Lim SG. The efficacy of hepatitis B treatments in achieving HBsAg seroclearance: A systematic review and meta-analysis. J Viral Hepat. 2020 Jul;27(7):650-662.
  10. Wong GL, Wong VW, Thompson A, Jia J, Hou J, Lesmana CRA, Susilo A, Tanaka Y, Chan WK, Gane E, Ong-Go AK, Lim SG, Ahn SH, Yu ML, Piratvisuth T, Chan HL; Asia-Pacific Working Group for Liver Derangement during the COVID-19 Pandemic. Management of patients with liver derangement during the COVID-19 pandemic: an Asia-Pacific position statement. Lancet Gastroenterol Hepatol. 2020 Aug;5(8):776-787. doi: 10.1016/S2468-1253(20)30190-4. Epub 2020 Jun 23.

Professional Memberships

  • Fellow of the Royal Australasian College of Physicians
  • Fellow of the Royal College of Physicians of London
  • Member, Gastroenterological Society of Singapore
  • Member, Gastroenterological Society of Australia
  • Fellow, Academy of Medicine of Singapore
  • Fellow, American Association for Liver Disease
  • Member, European Association for Study of Liver

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