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Dr David Lu

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  • Associate Consultant, Division of Paediatric Nephrology, Dialysis and Renal Transplantation, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital


BA (Hons) (Cantab), MB BChir (Cantab), MMed (Paediatric Medicine) (Singapore), MRCPCH (UK)


Paediatric Nephrology

Clinical Disciplines/Programmes:

Paediatric Nephrology, Dialysis & Renal Transplantation (Kidney, Bladder & Urine Conditions)


Dr David Lu is an Associate Consultant in the Division of Nephrology, Dialysis and Renal Transplantation, Department of Paediatrics at Khoo Teck Puat – National University Children’s Medical Institute (KTP-NUCMI). Dr Lu began his medical training at the University of Cambridge, where he graduated with Bachelor of Arts in Medical Sciences (First Class Honours) in 2013 and subsequently Bachelor of Medicine and Bachelor of Surgery (with Distinction) in 2016. During this time, he received several academic prizes, including the Ackroyd Scholarship (2011-2015), Schuldham Plate, William Harvey Studentship for Clinical Medicine and the George Peter Baker Prize.

Dr Lu subsequently underwent further post-graduate training in Paediatrics at KTP-NUCMI, National University Hospital from 2016 to 2022 and received the Master of Medicine (Paediatric Medicine) and Membership of the Royal College of Paediatrics and Child Health in 2019, before qualifying as a Paediatrician in 2023. During this time, Dr Lu also served as Assistant Chief Resident (2020-2021), and as a Clinical Tutor at the Yong Loo Lin School of Medicine, National University of Singapore since 2021.

Dr Lu has been active in clinical and translational research for several years. He has received a number of prizes in recognition of this, including the IFPA YW Loke New Investigator Travel Award (2013) and the EPSE Henning Andersen Award (2017). His current interests include the immunological basis of idiopathic nephrotic syndrome, biomarkers for early chronic kidney disease, and novel therapeutics in nephrology.


  • 2022 - NUHS Residency Research Award (Bronze)
  • 2020 - NUHS Clinician Scientist Programme-Residency: Best Oral Presentation

Journals & Publications

  1. Lu L*, Chan CY*, Chan‐Ng PPL*, et al. Heterogenous antibody and T‐cell responses to SARS‐CoV‐2 mRNA vaccines among immunocompromised young people. Clin Transl Med. 2023;13(1). doi:10.1002/ctm2.1183 [IF: 8.554] * Joint first authors
  2. Wong LSY, Loo EXL, Huang C-H, Yap GC, Tay MJY, Chua RXY, Kang AYH, Lu L, et al. (2022) Early seasonal coronavirus seroconversion did not produce cross-protective SARS-CoV-2 antibodies. J Infect. doi:10.1016/j.jinf.2022.08.032 [IF: 38.637]
  3. Zhang Y*, Lu L*, Hu Z*, et al. (2022) Angiomotin mutation causes glomerulopathy and renal cysts by upregulating hepatocyte nuclear factor transcriptional activity. Clin Transl Med. 2022;12(6). doi:10.1002/ctm2.904. [IF: 8.554] *Joint first authors
  4. Zhang Y, Lu L, Yap HK, Ng KH (2022) Hepatocyte nuclear factors play an important role in the pathogenesis of nephropathy. Clin Transl Discov. 2022;2(2). doi:10.1002/ctd2.97
  5. Lu L*, Yap YC* et al., on behalf of Deciphering Diversities: Renal Asian Genetics Network (DRAGoN) (2022) Multicenter study on the genetics of glomerular diseases among Southeast and South Asians: The DRAGoN study. Clin Genet. 2022;101(5-6):541-551. doi:10.1111/cge.14116. [IF: 4.438] *Joint first authors
  6. Chua H-R, Zheng K, Vathsala A, Ngiam K-Y, Yap H-K, Lu L, et al. (2022) Health Care Analytics With Time-Invariant and Time-Variant Feature Importance to Predict Hospital-Acquired Acute Kidney Injury: Observational Longitudinal Study. J Med Internet Res. 2021;23(12):e30805. doi:10.2196/30805 [IF: 7.08]
  7. Chan CY*, Teo S*, Lu L*, Chan YH, Lau PYW, Than M, Jordan SC, Lam KP, Ng KH, Yap HK (2021) Low regulatory T-cells: A distinct immunological subgroup in minimal change nephrotic syndrome with early relapse following rituximab therapy. Transl Res. 2021;235:48-61. doi:10.1016/j.trsl.2021.03.019. [IF: 5.411] *Joint first authors
  8. Lu L, Koh CT, Lim YH, Sng A, Poon KS, Tan SSY, Kao PT, Tee N, Yap HK, Lee BW, Tambyah PA (2021) Role of asymptomatic children in community SARS-CoV-2 transmission. J Infect Dis. 2021;223(10):1834-1836. doi:10.1093/infdis/jiab138. [IF: 5.022]
  9. Low LD*, Lu L*, Chan CY*, Chen J, Yang HH, Yu H, Lee CGL, Ng KH, Yap HK (2020) IL-13-driven alterations in hepatic cholesterol handling contribute to hypercholesterolemia in a rat model of minimal change disease. Clin Sci (Lond). 2020;134(2):225-237. doi:10.1042/CS20190961. [IF: 5.237] *Joint first authors
  10. Petry CJ, Koulman A, Lu L, Jenkins B, Furse S, Prentice P, Matthews L, Hughes IA, Acerini CL, Ong KK, Dunger DB (2018) Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study. Reprod Biol Endocrinol. 2018;16(1):82. doi:10.1186/s12958-018-0399-x [IF: 2.852]

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