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Dr Daryl Chia Kai Ann

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  • Consultant, Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery, National University Hospital
  • Consultant, Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery, Alexandra Hospital


MBBS (Singapore), MRCS (Ire), MCI (NUS), MMed (Surgery), FRCS (Edin)


General Surgery

Clinical Disciplines/Programmes:

Bariatric & Metabolic Surgery, Minimally Invasive Surgery, Surgical Oncology (Upper Gastrointestinal Surgery), Upper Gastrointestinal Surgery

Special Interests:

Upper Gastrointestinal Surgery (Esophageal and Gastric Cancer), Metabolic and Bariatric Surgery, Benign Foregut Disorders, Diagnostic & Therapeutic Endoscopy, Minimally-Invasive Surgery


"In my practice, I believe that biology is king; understanding the mechanisms behind the diseases I treat is crucial to selecting the right treatment for the right patient. Every patient is unique and hence, every treatment plan is designed to meet the individual's needs."

Dr Daryl Chia is currently an Associate Consultant in the Departments of Surgery at the National University Hospital & Alexandra Hospital, with a sub-speciality interest in Upper Gastrointestinal Surgery. He graduated from the National University of Singapore (NUS) in 2013 and joined the General Surgery Residency Programme at the National University Hospital in 2016. He obtained a Masters in Clinical Investigation (NUS) & Masters of Medicine (Surgery) in 2019 while in training. In 2022, he completed General Surgery training and obtained the Fellowship of the Royal College of Surgeons of Edinburgh and received accreditation by the Specialist Accreditation Board in General Surgery. Dr Chia's clinical interests include bariatric surgery, benign foregut conditions (reflux disease, achalasia, paraesophageal hernia), esophageal and gastric cancers, advanced endoscopy, enteral access procedures and laparoscopic hernia repair.

Bridging unmet clinical needs with translational research

Dr Chia has a keen interest in improving care for patients through research. He received the Ministry of Health Healthcare Research Scholarship in 2017 where he undertook a Masters in Clinical Investigation as part of his research training. His current research interests include biological mechanisms in peritoneal metastases and its tumour microenvironment. To support and further advance his research, he has won competitive grants (ExxonMobil-NUS Research Fellowship, NUHS Seed Grant & NMRC Research Training Fellowship). He is also actively involved in clinical outcomes research for gastric cancer, bariatric and metabolic surgery and minimally-invasive surgery having authored more than 20 papers and multiple poster and oral presentations at international meetings. Through clinical and translational research, he hopes to bring the best treatment options to patients with advanced cancers and morbid obesity.

Teaching the next generation

Dr Chia is also actively involved in undergraduate and postgraduate medical education and has received teaching awards in recognition of his contributions. He currently serves as Clinical Tutor, Yong Loo Lin School of Medicine in addition to his roles as Core Faculty, Post-Graduate Year 1 (PGY1) and Surgery-in-General programmes.


  • 2022 – NMRC RTF
  • 2022 – NUHS Seed grant
  • 2022 - ExxonMobil-NUS Research Fellowship
  • 2020 - NUS Medicine Junior Doctor Teaching Award
  • 2020 - Residents’ Choice Award

Journals & Publications

  1. Chia DKA, Demuytere J, …, Ceelen W. Effects of Hyperthermia and Hyperthermic Intraperitoneal Chemoperfusion on the Peritoneal and Tumour Immune Contexture. Cancers (Basel). 2023 Aug 9;15(17):4313.
  2. Chia DKA, Sundar R, Guowei K, ..., So J, Yong WP. Outcomes of a Phase II Study of Intraperitoneal Paclitaxel plus Systemic Capecitabine and Oxaliplatin (XELOX) for Gastric Cancer with Peritoneal Metastases. Ann Surg Oncol 2022. In press
  3. Chia DKA, Gwee YX, Sundar R. Resistance to systemic immune checkpoint inhibition in the peritoneal niche. J Immunother Cancer. 2022 Jun;10(6):e004749. doi: 10.1136/jitc-2022-004749. PMID: 35728873.
  4. Gwee YX, Chia DKA, So J, Ceelen W, Yong WP, Tan P, Ong CJ, Sundar R. Integration of Genomic Biology Into Therapeutic Strategies of Gastric Cancer Peritoneal Metastasis. J Clin Oncol. 2022 Jun 1:JCO2102745. doi: 10.1200/JCO.21.02745. Epub ahead of print. PMID: 35649219.
  5. Chia DKA, Lim Z, Ang JJ, Tambyah PA, Lau KSH, Ong J, Chow VTK, Allen DM, Fung J, Lau KJX, Luhung I, Schuster SC, Lee CN, Kim G, So JBY, Lomanto D, Shabbir A. Coronavirus viability in surgical plume and methods for safe disposal: a preclinical model. Br J Surg. 2021 Dec 17;109(1):15-20. doi: 10.1093/bjs/znab385. PMID: 34792098.
  6. Ang JJ, Chia DKA, Chan DKH. Lymphocyte-White Cell Ratio Is a Novel Marker of Morbidity Following Colorectal Cancer Surgery. J Surg Res. 2021 Mar;259:71-78. doi: 10.1016/j.jss.2020.11.027. Epub 2020 Dec 3. PMID: 33279846.
  7. Chan DKH, Ang JJ, Tan JKH, Chia DKA. Age is an independent risk factor for increased morbidity in elective colorectal cancer surgery despite an ERAS protocol. Langenbecks Arch Surg. 2020 Aug;405(5):673-689. doi: 10.1007/s00423-020-01930-y. Epub 2020 Jul 8. PMID: 32642863.
  8. Chia DKA, So JBY. Recent Advances in Intra-peritoneal Chemotherapy for Gastric Cancer. J Gastric Cancer. 2020 Jun;20(2):115-126. doi: 10.5230/jgc.2020.20.e15. Epub 2020 Apr 10. PMID: 32595996; PMCID: PMC7311211.
  9. Chia DKA, Lomanto D, Wijerathne S. Patient-Reported Outcomes and Long-Term Results of a Randomized Controlled Trial Comparing Single-Port Versus Conventional Laparoscopic Inguinal Hernia Repair. World J Surg. 2020 Jul;44(7):2191-2198. doi: 10.1007/s00268-020-05443-z. PMID: 32123978.
  10. Chia DKA, Kim G, Chang HSY, Toh BC, So JBY, Shabbir A. Kamikawa Double-Flap Reconstruction After Minimally Invasive Ivor-Lewis Esophagectomy. Ann Thorac Surg. 2019 Jul;108(1):e57-e59. doi: 10.1016/j.athoracsur.2019.01.077. Epub 2019 Mar 12. PMID: 30872101.

Professional Memberships

  • Member, Royal College of Surgeons (Ireland)
  • Fellow, Royal College of Surgeons (Edinburgh)
  • Member, Obesity and Metabolic Surgery Society of Singapore (OMSSS)
  • Member, International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO)

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National University Health System
  • National University Hospital
  • Ng Teng Fong General Hospital
  • Alexandra Hospital
  • Jurong Community Hospital
  • National University Polyclinics
  • Jurong Medical Centre
  • National University Cancer Institute, Singapore
  • National University Heart Centre, Singapore
  • National University Centre for Oral Health, Singapore
  • NUHS Diagnostics
  • NUHS Pharmacy
  • Yong Loo Lin School of Medicine
  • Faculty of Dentistry
  • Saw Swee Hock School of Public Health
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