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Asst Prof Cyrus Ho

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  • Senior Consultant, Department of Psychological Medicine, National University Hospital
  • Assistant Professor, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (S’pore), Dip (Cl Psy) (RCP&S, Ire), FRCPsych (UK), Grad Dip Acupuncture (S’pore), MSc (Research) (S’pore), MSc (App Neurosci) (UK), PhD (S’pore), FAMS (Psy) (S’pore), IFAPA (USA)



Clinical Disciplines/Programmes:

General Adult Psychiatry

Special Interests:

Mood disorders, Neuropsychiatry

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Dr Cyrus Ho manages psychiatric conditions across the age continuum from adolescence to old age. He is also the clinical lead for the Repetitive Transcranial Magnetic Stimulation (rTMS) service in the Department of Psychological Medicine. He is interested in interfacing between medicine and psychiatry, complex mood disorders, neuropsychiatry and public mental health.

He studied medicine at NUS and subsequently obtained a Master of Science in Research from NUS for his work on neuroimaging in depressed and chronic pain patients, a Master of Science in Applied Neuroscience (Distinction) from King’s College London and a doctorate from NUS for his research work on improving the diagnostic accuracy of depression using multimodal biomarkers. He also underwent neuropsychiatry training at the Montreal Neurological Hospital in Canada and the Royal Melbourne Neuropsychiatry Unit in Australia under the Ministry of Health (MOH) Health Manpower Development Plan award, where he enhanced his expertise in the diagnosis and management of patients with complex neurological and psychiatric needs. He was conferred as a Fellow of the Royal College of Psychiatrists (UK), the American Psychiatric Association and the Singapore Academy of Medicine for his contribution to Psychiatry.

Being an avid researcher, Dr Ho has published more than 340 academic papers in international peer-reviewed journals, including The Lancet, JAMA Pediatrics, Annals of Internal Medicine, Autoimmunity Reviews and Brain, Behavior and Immunity. He is also the Associate Editor for the British Journal of Psychiatry and the Frontiers in Psychiatry. Clarivate Analytics (Web of Science) has recognised him as one of the most highly cited researchers in the world for his contributions to cross-field research from 2021 to 2023.

He teaches at undergraduate and postgraduate levels. He currently serves as the NUS Psychiatry Undergraduate Education Director and is the Assistant Dean (Student Life and Wellbeing) of the NUS Graduate School. He is also an examiner for the postgraduate clinical examination conducted by the Royal College of Psychiatrists, UK. His recognition in education is exemplified by the several teaching awards that he has received, such as the NUS Annual Digital Education Award, Yong Loo Lin School of Medicine Digital Education Award, Dean's Award for Teaching Excellence and Junior Doctor Teaching Award. He has co-authored four postgraduate guidebooks published by Taylor and Francis and the Mastering Psychiatry Textbook, a popular reference book used by Singapore medical students during their clinical postings.

Always interested in pushing the boundaries of research to effect innovative healthcare, Dr Ho welcomes clinical and research collaboration locally and internationally.


  • NMRC Transition Award (2023)
  • NUS Annual Digital Education Award (2023)
  • Yong Loo Lin School of Medicine Digital Education Award (2023)
  • Clarivate Highly Cited Researcher - Cross Field (2023, 2022, 2021)
  • Dean's Award for Teaching Excellence, NUS (2023, 2021,2020, 2018)
  • NUS Engineering in Medicine pitch-for-fund contest – Award (2021)
  • NUHS Teaching Excellence Award (2021)
  • Japanese Society of Psychiatry and Neurology Fellowship Award (2020)
  • NUS Medicine Fortitude Award (2020)
  • MOH Health Manpower Development Plan (HMDP) Award (2018)

Journals & Publications

  1. Ho CSH, Wang J, Tay GWN, et al. Interpretable deep learning model for major depressive disorder assessment based on functional near-infrared spectroscopy. Asian J Psychiatr. 2024 Jan 3;92:103901. [IF 9.5]
  2. Lee ARYB, Low CE,…, Ho CSH. Lifetime Burden of Psychological Symptoms, Disorders, and Suicide Due to Cancer in Childhood, Adolescent, and Young Adult Years: A Systematic Review and Meta-analysis. JAMA Pediatr. 2023 Jun 22:e232168. [IF 26.8]
  3. Li T, Yuan L, Zhao Y,…, Ho CSH. Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice. J Affect Disord. 2023 Feb 24:S0165-0327(23)00273-2. [IF 6.533]
  4. Ho CSH, Tay GWN, Wee HN, et al. The Utility of Amino Acid Metabolites in the Diagnosis of Major Depressive Disorder and Correlations with Depression Severity. International Journal of Molecular Sciences. 2023 Jan 23; 24(3):2231. [IF 5.6]
  5. Ho CSH, Soh MWT, Tay GWN. The diagnostic utility of miRNA and elucidation of pathological mechanisms in major depressive disorder. Compr Psychiatry. 2022 Dec 23;121:152363. [IF 7.3]
  6. Lam RW, Wong HK, Kumarsing RA,…, Ho CS. Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress - an animal model of depression. Transl Psychiatry. 2022 Aug 20;12(1):339. [IF 6.8]
  7. Li Z, McIntyre RS, Husain SF,…, Ho CS, Chen N. Identifying neuroimaging biomarkers of major depressive disorder from cortical hemodynamic responses using machine learning approaches. EBioMedicine. 2022 Apr 28;79:104027. [IF 11.2]
  8. Ho CS, Chan YL, Tan TW, et al. Improving the diagnostic accuracy for major depressive disorder using machine learning algorithms integrating clinical and near-infrared spectroscopy data. J Psychiatr Res. 2022 Jan 12;147:194-202. [IF 4.8]
  9. Li H, Xiang Y, Zhu Z,…, Ho CSH. Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat. J Neuroinflammation. 2021 Nov 4;18(1):254. [IF 9.3]
  10. Wang C, Pan R,…, Ho C. A Longitudinal Study on the Mental Health of General Population during the COVID-19 Epidemic in China. Brain Behav Immun. 2020 Apr 13. pii: S0889-1591(20)30511-0. [IF 15.1]

Professional Memberships

  • Fellow, Royal College of Psychiatrists, United Kingdom
  • Fellow (Psychiatry), Academy of Medicine Singapore
  • International Fellow, American Psychiatric Association, United States
  • Fellow, International Society for Affective Disorders
  • Member, American Neuropsychiatric Association, United States
  • Member, Academy of Consultation-Liaison Psychiatry, United States

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