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Dr Chua Horng Ruey

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  • Head & Senior Consultant, Division of Nephrology, Department of Medicine, National University Hospital
  • Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (NUS), MMed (NUS), MRCP (UK), FRCP (Edinburgh), FAMS (Singapore), Fellow of American Society of Nephrology, Grad Cert (digital health and certified healthcare analytical professional, SMU, S’pore), Certified Specialist in Renal Medicine, Singapore


Renal Medicine

Clinical Disciplines/Programmes:


Special Interests:

Acute kidney injury, Biomarkers of renal tubular injury, Informatics, Data analytics to predict kidney disease, Continuous renal replacement therapy, Critical care nephrology, Metabolic syndrome.

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Dr Chua Horng Ruey obtained his Bachelor of Medicine and Surgery in 2002 and his Master of Medicine (Internal Medicine) in 2007, both from the National University of Singapore. He is a certified Specialist in Renal Medicine, appointed by the Singapore Medical Council in June 2011. Dr Chua was appointed to be on the Specialists Accreditation Board, Ministry of Health in June 2011. He was elected Fellow of Academy of Medicine (Singapore) and Fellow of Royal College of Physicians (Edinburgh) since 2015, and Fellow of American Society of Nephrology since 2017. He was awarded the Healthcare Manpower Development Program by Ministry of Health Singapore in 2010 for his post-graduate training in critical care nephrology at the department of intensive care in Austin Health, Melbourne, Australia. He is a recipient of the Transition Award by the National Medical Research Council, Singapore, in 2019 for his studies on acute kidney injury and nephrotoxicity. He has obtained further graduate certification in digital health and healthcare analytics from Singapore Management University Academy in 2020. His clinical interests are in acute kidney injury, both preventive care and organ failure support, cancer and kidney disease, as well as metabolic syndrome and cardiovascular disease.

Dr Chua is currently a Senior Consultant with the Division of Nephrology at the National University Hospital and is the Director of Informatics.

Journals & Publications

Selected publications

  1. Chua HR, Low S, Murali TM, Wong ET, He HD, Teo BW, Thian YL, Akalya K, Vathsala A.
    Cumulative iodinated contrast exposure for computed tomography during acute kidney injury and major adverse kidney events.
    European Radiology. 2020 Nov 7. Online.
  2. Chua HR, MacLaren G, Choong LH, Chionh CY, Khoo BZE, Yeo SC, Sewa DW, Ng SY, Choo JC, Teo BW, Tan HK, Siow WT, Agrawal RV, Tan CS, Vathsala A, Tagore R, Seow TY, Khatri P, Hong WZ, Kaushik M.
    Ensuring sustainability of continuous kidney replacement therapy in the face of extraordinary demand: Lessons from the COVID-19 pandemic.
    Journal of Kidney Diseases. 2020; 76(3):392-400.
  3. Low S, Vathsala A, Murali TM, Pang L, MacLaren G, Ng WY, Haroon S, Mukhopadhyay A, Lim SL, Tan BH, Lau T, Chua HR.
    Electronic health records accurately predict renal replacement therapy in acute kidney injury.
    Nephrology. 2019 Jan 31;20(1):32.
  4. Chua HR, Wong WK, Ong VH, Agrawal D, Vathsala A, Tay HM, Mukhopadhyay A.
    Extended mortality and chronic kidney disease after septic acute kidney injury.
    Journal of Intensive Care Med. 2020 Jun;35(6):527-535.
  5. Da Y, Akalya K, Murali T, Vathsala A, Tan CS, Low S, Lim HN, Teo BW, Lau T, Ong L, Chua HR.
    Serial Quantification of Urinary Protein Biomarkers to Predict Drug-induced Acute Kidney Injury.
    Current Drug Metabolism. 2019;20(8):656-664.
  6. Tan JN, Haroon SW, Mukhopadhyay A, Lau T, Murali TM, Phua J, Tan ZY, Lee N, Chua HR.
    Hyperlactatemia Predicts Citrate Intolerance With Regional Citrate Anticoagulation During Continuous Renal Replacement Therapy.
    Journal of Intensive Care Med. 2019; 34(5):418-25.
  7. Ong LZ, Tambyah PA, Lum LH, Low ZJ, Cheng I, Murali TM, Wan MQ, Chua HR.
    Aminoglycoside-associated acute kidney injury in elderly patients with and without shock.
    Journal of Antimicrobial Chemotherapy. 2016 Nov;71(11):3250-3257.
  8. Chua HR, Schneider AG, Sherry NL, Lotfy N, Chan MJ, Galtieri J, Wong GR, Lipcsey M, Matte CD, Collins A, Garcia-Alvarez M, Bellomo R.
    Initial and Extended Use of Femoral Versus Nonfemoral Double-Lumen Vascular Catheters and Catheter-Related Infection During Continuous Renal Replacement Therapy.
    American Journal of Kidney Diseases. 2014; 64(6):909-17.

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