Health Resources

Obesity (Children)

2026/05/19
What is Obesity

Childhood obesity is a complex chronic disease of excess adiposity accumulation, and is increasing in prevalence throughout the world, including Singapore.  

In Singapore, childhood obesity (2 to 18 years) is defined based on body mass index (BMI) percentile, where a BMI percentile of ≥90th to 97th is categorized as overweight, while those ≥97th percentile is considered severely overweight (obesity). 

The BMI is calculated using the formula below:

BMI = weight (kg) ÷ [height (m)]2

Causes of Obesity

Obesity results from a combination of factors, including dietary (unhealthy eating, excessive calories intake, high ultra-processed food, sugar-sweetened beverages), inadequate physical activity, abnormal neurobiology, the gut microbiome and genetic influences. In some children, specific diseases and medications can lead to obesity. 

Signs And Symptoms of Obesity

Immediate health concerns linked to obesity include Diabetes Mellitus, high blood pressure, hyperlipidaemia, fatty liver, obstructive sleep apnoea (OSA), irregular menstrual cycles, joint issues, depression and low self-esteem. In our clinic, healthcare professionals assess these through questioning, physical examinations and blood tests.

Long-term risks include persistent adult obesity and increased likelihood of heart disease, stroke, osteoarthritis and various cancers.

Diagnosis and Treatment Options for Obesity
Effective weight management requires motivation for behavioural change and sustained lifestyle modifications through healthy eating, regular exercise and good sleep. Motivation is key to success, with support from family, friends, schools and healthcare professionals being crucial. Some patients may benefit from more advance weight management therapies, including medications (such as the GLP-1 receptor agonist therapy) or bariatric surgery. These will be decided by the physician. 

Our multidisciplinary weight management team comprises a paediatrician, a dietitian, an occupational therapist, a physiotherapist and a nurse clinician. This team provides comprehensive care, including monitoring and treating obesity-related complications, dietary customisation, motivational support, parenting strategies and exercise guidance. 
Tips for Taking Care of Obese Children

Children and adolescents with obesity may face social pressures and experience low self-esteem, bullying and depression. As parents, it’s essential to provide encouragement, refrain from judgement and model healthy lifestyle choices. Constant criticism can be counterproductive, leading to resistance to healthy changes.

Research on Obesity

Continued clinical research is essential for advancing paediatric healthcare. Our doctors are committed to contributing to the future of child health and medicine through both clinical practice and research.

  1. Ng NBH, Sng AA, Huang JG (2026). Fighting the epidemic of pediatric metabiolic dysfunction-associated steatotic liver disease: Role of non-invasive diagnostics and early pharmacological intervention. World J Hepatol. 27;18(1):111211 
  2. Lim CYS, Loke KY, Varughese SM, Lee YS, Ng NBH (2026). Evaluation and Management of Polycystic Ovarian Synrome (PCOS) in Adolescents with Obesity: A Scoping Review of National and International Obesity and PCOS Management Guidelines. Obes Rev. doi: 10.1111/obr.70072 
  3. Ng NBH, Lim CYS, Tan SCHL, Foo YW, Tok CLX, Lim YYJ, Goh DTY, Loke KY, Lee YS (2024). Screening for OSA in children and adolescents with obesity: A scoping review of national and international pediatric obesity and pediatric OSA management guidelines. Obes Rev. 25(5):e13712
  4. Ng VWW, Gerard G, Koh JJK, Loke KY, Lee YS, Ng NBH (2024). The role of glucagon-like peptide 1 receptor agonists for weight control in individuals with acquired hypothalamic obesity- A systematic review. Clin Obes; 2024; 14(3)
  5. Lim CYS, Foo YW, Tok CLX, Lim YYJ, Loke KY, Lee YS, Ng NBH. (2022) Screening for metabolic complications of childhood and adolescent obesity: A scoping review of national and international guidelines. Obes Rev. 23(12):e13513 
  6. Ng NBH, Low YW, Rajgor DD, Low JM, Lim YYJ, Loke KY, Lee YS. (2022). The effects of glucagon-like peptide (GLP)-1 receptor agonists on weight and glycaemic control in Prader-Willi syndrome: A systematic review. Clin Endocrinol (Oxf). 96(2):144-154 
  7. Fogel A, Goh AT, Fries LR, Sadananthan SA, Shek LP, Lee YS, . . . Forde CG (2017). Faster eating rates are associated with higher energy intakes during an ad libitum meal, higher BMI and greater adiposity among 4•5-year-old children: results from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort. The British Journal of Nutrition, 117(7):1042-1051. doi: 10.1017/S0007114517000848
  8. Lin X, Lim IY, Wu Y, Teh AL, Chen L, Lee YS, . . . GUSTO study group (2017). Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Medicine, 15(1):50. doi: 10.1186/s12916-017-0800-
  9. Fogel A, Goh AT, Fries LR, Sadananthan SA, Shek LP, Lee YS, . . . Forde CG (2017). A description of an 'obesogenic' eating style that promotes higher energy intake and is associated with greater adiposity in 4.5year-old children: Results from the GUSTO cohort. Physiology & Behavior, 176:107-116. doi: 10.1016/j.physbeh.2017.02.013
  10. Chen LW, Aris IM, Bernard JY, Tint MT, Colega M, Shek LP, . . . Lee YS (2017). Associations of maternal macronutrient intake during pregnancy with infant BMI peak characteristics and childhood BMI.The American Journal of Clinical Nutrition, 105(3):705-713. doi:10.3945/ajcn.116.148270
  11. Chen LW, Aris IM, Bernard JY, Tint MT, Chia A, Shek LP, . . . Lee YS (2016). Associations of Maternal Dietary Patterns during Pregnancy with Offspring Adiposity from Birth Until 54 Months of Age. Nutrients, 9(1). doi: 10.3390/nu9010002
  12. Ooi DS, Ong SG, Heng CK, Loke KY, Lee YS (2016). In-vitro function of upstream visfatin polymorphisms that are associated with adverse cardiometabolic parameters in obese childrenBMC Genomics, 17(1):974. doi: 10.1186/s12864-016-3315-9
  13. Aris IM, Bernard JY, Chen LW, Tint MT, Pang WW, Lim WY, . . . Lee YS (2016). Infant body mass index peak and early childhood cardio-metabolic risk markers in a multi-ethnic Asian birth cohort.
    International Journal of Epidemiology. doi: 10.1093/ije/dyw232
  14. Lee YS, Biddle S, Chan MF, Cheng A, Cheong M, Chong YS, . . . Wang J (2016). Health Promotion Board-Ministry of Health Clinical Practice Guidelines: Obesity. Singapore Medical Journal, 57(6):292-300. doi: 10.11622/smedj.2016103
  15. Chong MF, Ayob MN, Chong KJ, Tai ES, Khoo CM, Lee YS, . . . Khoo EY (2016). Psychometric analysis of an eating behaviour questionnaire for an overweight and obese Chinese population in Singapore. Appetite, 101:119-24. doi: 10.1016/j.appet.2016.03.005
  16. Leow SC, Poschmann J, Too PG, Yin J, Joseph R, Lee YS, . . . Stünkel W (2016). The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Development (Cambridge, England), 143(6):950-61. doi: 10.1242/dev.131573
  17. Aris IM, Soh SE, Tint MT, Saw SM, Rajadurai VS, Godfrey KM, . . . Lee YS (2015). Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population. The American Journal of Clinical Nutrition, 102(5):1104-12. doi: 10.3945/ajcn.115.117614
  18. Parvaresh Rizi E, Teo Y, Leow MK, Khoo EY, Yeo CR, Lee YS, . . . Khoo CM (2015). Ethnic Differences in the Role of Adipocytokines Linking Abdominal Adiposity and Insulin Sensitivity Among Asians. The Journal of Clinical Endocrinology and Metabolism, 100(11):4249-56. doi: 10.1210/jc.2015-2639 
  19. Quah PL, Chan YH, Aris IM, Pang WW, Toh JY, Lee YS, . . . GUSTO study group (2015). Prospective associations of appetitive traits at 3 and 12 months of age with body mass index and weight gain in the first 2 years of life. BMC Pediatrics, 15(1):153. doi: 10.1186/s12887-015-0467-8
  20. Lin X, Aris IM, Tint MT, Soh SE, Godfrey KM, Yeo GS, . . . Lee YS (2015). Ethnic differences in effects of maternal pre-pregnancy and pregnancy adiposity on offspring size and adiposity. The Journal of Clinical Endocrinology and Metabolism, 100(10):3641-50. doi: 10.1210/jc.2015-1728
  21. Pan H, Lin X, Wu Y, Chen L, Teh AL, Lee YS, . . . GUSTO Study Group (2015). HIF3A association with adiposity: the story begins before birth. Epigenomics, 7(6):937-50. doi: 10.2217/epi.15.45
  22. Ho CW, Loke KY, Lim YY, Lee YS (2014). Exogenous Cushing syndrome: a lesson of diaper rash cream. Hormone Research in Paediatrics, 82(6):415-8. doi: 10.1159/000363517 
  23. Tan KML, Ooi SQ, SG Ong, CS Kwan, Chan RME, Loke KY, . . . Lee YS (2014). Functional characterization of variants in MC4R gene promoter region found in obese children.The Journal of Clinical Endocrinology and Metabolism, 99(5):E931-5. doi: 10.1210/jc.2013-3711
  24. Ooi SQ, Chan RM, Poh LK, Loke KY, Heng CK, Chan YH, . . . Lee YS (2014). Visfatin and its genetic variants are associated with obesity-related morbidities and cardiometabolic risk in severely obese children. Pediatric Obesity, 9(2):81-91. doi: 10.1111/j.2047-6310.2013.00149.
  25. Aris IM, Soh SE, Tint MT, Shen L, Chinnadurai A, Saw SM, . . . Lee YS (2014). Effect of maternal glycemia on neonatal adiposity in a multiethnic Asian birth cohort. The Journal of Clinical Endocrinology and Metabolism, 99(1): 240-7. doi: 10.1210/jc.2013-2738
  26. Lee YS (2013). Genetics of nonsyndromic obesity. Current Opinion in Pediatrics, 25(6):666-73. doi: 10.1097/MOP.0b013e3283658fba
  27. Chen YY, Chan RME, Tan MLK, Poh LKS, Loke KY, Wang JP, . . . Lee YS (2013). The association of a Nucleobindin 2 gene (NUCB2) variant with childhood adiposity. Gene, 516(1):48-52. doi: 10.1016/j.gene.2012.12.017
  28. Pwint MK, Lee YS, Wong TY, Saw SM (2013). Prevalence of overweight and obesity in Chinese preschoolers in Singapore. Annals Academy of Medicine, Singapore, 42(2):66-72.
  29. Lee YS (2012). Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective. Diabetes/Metabolism Research and Reviews, 28(S2): 26-31. doi: 10.1002/dmrr.2351
  30. Lee YS (2009). The role of leptin-melanocortin system and human weight regulation: lessons from experiments of nature.Annals Academy of Medicine, Singapore, 38(1):34-11.
  31. Lee YS (2009). The role of genes in the current obesity epidemic. Annals Academy of Medicine, Singapore, 38(1):45-3.
  32. Lee YS (2009). Consequences of Childhood Obesity. Annals Academy of Medicine, Singapore, 38(1):75-7.
  33. Lee YS, So JB, Deurenberg-Yap M (2009). Confronting the obesity epidemic: call to arms. Annals Academy of Medicine, Singapore, 38(1):1-2.
  34. Creemers JWM, Lee YS, Oliver RL, Bahceci M, Tuzcu A, Gokalp D, . . . Farooqi IS (2008). Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway. The Journal of Clinical Endocrinology and Metabolism, 93(11):4494-9. doi: 10.1210/jc.2008-0954
  35. Lee YS, Kek BLK, Poh LKS, Saw SM, Loke KY (2008). Association of raised liver transaminases with physical inactivity, increased waist-hip ratio, and other metabolic morbidities in severely obese children. Journal of Pediatric Gastroenterology and Nutrition, 47(2):172-8. doi: 10.1097/MPG.0b013e318162a0e5
  36. Lee YS, Poh LKS, Kek BLK, Loke KY (2008). Novel Melanocortin 4 receptor gene mutations in severely obese children. Clinical Endocrinology, 68(4):529-35. doi: 10.1111/j.1365-2265.2007.03071.
  37. Lee YS, Poh LKS, Kek BLK, Loke KY (2007). The role of melanocortin 3 receptor gene in childhood obesity. Diabetes, 56(10):2622-30. doi: 10.2337/db07-0225
  38. Lee YS, Challis B, Thompson D, Yeo G, Keogh J, Madonna M, . . . Farooqi IS (2006). A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metabolism, 3(2):135-40. doi: 10.1016/j.cmet.2006.01.006 
  39. Lee YS, Poh LKS, Loke KY (2002). A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity. The Journal of Clinical Endocrinology and Metabolism, 87(3):1423-6. doi: 10.1210/jcem.87.3.8461
  40. Lee YS, K Y Loke (2000). The molecular pathogenesis of obesity: An unfinished jigsaw puzzle. Annals Academy of Medicine, Singapore, 29(3):388-95.
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