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Dr Nicholas Chew

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  • Associate Consultant, Department of Cardiology, National University Heart Centre, Singapore


MBChB, MCI, MMed (Internal Medicine), MRCP (UK)



Clinical Disciplines/Programmes:

Coronary Heart Disease, General Cardiology, Interventional Cardiology


National University Health System, National University Heart Centre, Singapore, National University Hospital

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Dr Nicholas Chew is an Associate Consultant with the Department of Cardiology, National University Heart Centre, Singapore (NUHCS). He graduated from the University of Auckland with a Bachelor of Medicine, Bachelor of Surgery in 2016. He obtained his Membership of the Royal College of Physicians (UK) in 2019 and completed his Internal Medicine residency in 2020. Thereafter, he completed his Cardiology specialty training with the National University Heart Centre Singapore in 2023. During the residency training, he was selected for the Singapore Chief Residency Programme. In 2024, Dr Chew obtained the Master of Clinical Investigation degree from the National University of Singapore, and was awarded the National Medical Research Council Research Training Fellowship. 

Dr Chew holds an academic appointment as the Junior Academic Fellow with the Department of Medicine at the Yong Loo Lin School of Medicine. His key clinical and research passion lies in the early detection and timely management of coronary heart disease and heart attack. He is the Principal Investigator of several studies that uncover hidden risk factors of heart attack. He has obtained several grants, including the MOE Tier 1 grant and the NUHS Clinician-Scientist Programme Award, to support these studies. He has published more than 100 peer-reviewed articles, with publications in journals such as Cell Metabolism, Journal of the American College of Cardiology, Annals of Internal Medicine, and the Lancet Gastroenterology and Hepatology. Dr Chew has been an invited speaker at the Asia Pacific Association for the Study of the Liver (APASL), and has received Young Investigator Awards at both regional and international conferences. He also serves on the editorial boards of several internationally recognised journals.

Media coverage:

1. Daily Cuts - Obesity-related heart attacks. Channel News Asia. 6 June 2023

2. Study: 1 in 10 heart attack patients has no standard risk factors. The Straits Times, 9 July 2022

3. Nearly 10% of patients with heart attacks do not have risk factors. Channel News Asia. 8 July 2022.

4. (NUHCS study shows it took longer for heart attack patients to receive treatment after pandemic outbreak). Lianhe Zaobao. 22 February 2021.


  • ‚Äč2024 - NUHS Clinician-Scientist Programme V2.0 Award
  • 2023 - World's Top 2% Scientists List (2023)
  • 2023 - Singapore Medical Association Charity Fund (SMACF) Outstanding Mentor Award 2023
  • 2023 - NUHS Residency Research Award, Outstanding Young Investigator
  • 2022 - National Medical Research Council, Research Training Fellowship Award 2022
  • 2022 - Tier 1 MOE Seed Grant, 2022
  • 2022 - Young Investigator's Award (clinical science and overall winner) 1st prize, Singapore Cardiac Society 33rd Annual Scientific Meeting
  • 2022 - Young Investigator's Award (clinical science and overall winner) 2nd prize, Singapore Cardiac Society 33rd Annual Scientific Meeting
  • 2022 - 26th Asean Federation of Cardiology 2022, Young Investigator Award
  • 2022 - NUHS Residency Research Award, Gold
  • 2022 - NUHS Junior Pitch for Funds Grant 2022
  • 2021 - NUHS Residency Research Award, Silver
  • 2019 - Residency Excellence Award, Internal Medicine

Journals & Publications

  1. Chew NWS, Hui Pan X, Chong B, Chandramouli C, Muthiah M, Lam CSP. Type 2 diabetes mellitus and cardiometabolic outcomes in metabolic dysfunction-associated steatotic liver disease population. Diabetes Res Clin Pract. 2024 Apr 2:111652. doi: 10.1016/j.diabres.2024.111652. Epub ahead of print. PMID: 38574897.
  2. Pan XH, Tan B, Chin YH, Lee ECZ, Kong G, Chong B, Kueh M, Khoo CM, Mehta A, Majety P, Grandhi GR, Dimitriadis GK, Foo R, Chew NWS, Le Roux CW, Mamas MA, Chan MY. Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis. Obesity (Silver Spring). 2024 Feb 27. doi: 10.1002/oby.24002.
  3. Lee ECZ, Anand VV, Razavi AC, Alebna PL, Muthiah MD, Siddiqui MS, Chew NWS, Mehta A. The Global Epidemic of Metabolic Fatty Liver Disease. Curr Cardiol Rep. 2024 Apr;26(4):199-210. doi: 10.1007/s11886-024-02025-6.
  4. Figtree GA, Vernon ST, Harmer JA, Gray MP, Arnott C, Bachour E, Barsha G, Brieger D, Brown A, Celermajer DS, Channon KM, Chew NWS, Chong JJH, Chow CK, Cistulli PA, Ellinor PT, Grieve SM, Guzik TJ, Hagström E, Jenkins A, Jennings G, Keech AC, Kott KA, Kritharides L, Mamas MA, Mehran R, Meikle PJ, Natarajan P, Negishi K, O'Sullivan J, Patel S, Psaltis PJ, Redfern J, Steg PG, Sullivan DR, Sundström J, Vogel B, Wilson A, Wong D, Bhatt DL, Kovacic JC, Nicholls SJ; CRE for CAD Collaborators. Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review. J Am Coll Cardiol. 2023 Sep 26;82(13):1343-1359. doi: 10.1016/j.jacc.2023.06.045. 
  5. Chin YH, Lim O, Lin C, Chan YY, Kong G, Ng CH, Chong B, Syn N, Chan KE, Muthiah MD, Siddiqui MS, Wang JW, Figtree G, Chan MY, Chew NWS. Meta-analysis of the Placebo and Nocebo effects associated with Placebo treatment in randomized trials of lipid-lowering therapies. Eur Heart J Qual Care Clin Outcomes. 2023 Aug 7;9(5):511-519. doi: 10.1093/ehjqcco/qcac060.
  6. Chew NWS, Ng CH, Tan DJH, Kong G, Lin C, Chin YH, Lim WH, Huang DQ, Quek J, Fu CE, Xiao J, Syn N, Foo R, Khoo CM, Wang JW, Dimitriadis GK, Young DY, Siddiqui MS, Lam CSP, Wang Y, Figtree GA, Chan MY, Cummings DE, Noureddin M, Wong VW, Ma RCW, Mantzoros CS, Sanyal A, Muthiah MD. The global burden of metabolic disease: Data from 2000 to 2019. Cell Metab. 2023 Mar 7;35(3):414-428.e3. doi: 10.1016/j.cmet.2023.02.003
  7. Kong G, Chin YH, Chong B, Goh RSJ, Lim OZH, Ng CH, Muthiah M, Foo R, Vernon ST, Loh PH, Chan MY, Chew NWS, Figtree GA. Higher mortality in acute coronary syndrome patients without standard modifiable risk factors: Results from a global meta-analysis of 1,285,722 patients. Int J Cardiol. 2023 Jan 15;371:432-440. doi: 10.1016/j.ijcard.2022.09.062.
  8. Quek J, Chan KE, Wong ZY, Tan C, Tan B, Lim WH, Tan DJH, Tang ASP, Tay P, Xiao J, Yong JN, Zeng RW, Chew NWS, Nah B, Kulkarni A, Siddiqui MS, Dan YY, Wong VW, Sanyal AJ, Noureddin M, Muthiah M, Ng CH. Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023 Jan;8(1):20-30. doi: 10.1016/S2468-1253(22)00317-X. 
  9. Chew NW, Figtree GA, Kong G, Vernon S, Muthiah M, Ng CH, Chan MY, Loh PH. Hepatic steatosis and advanced fibrosis are independent predictors of mortality in acute myocardial infarction without standard modifiable risk factors. Diabetes Obes Metab. 2022 Dec;24(12):2454-2458. doi: 10.1111/dom.14820.
  10. Chew NWS, Chong B, Kuo SM, Jayabaskaran J, Cai M, Zheng H, Goh R, Kong G, Chin YH, Imran SS, Liang M, Lim P, Yong TH, Liew BW, Chia PL, Ho HH, Foo D, Khoo D, Huang Z, Chua T, Tan JWC, Yeo KK, Hausenloy D, Sim HW, Kua J, Chan KH, Loh PH, Lim TW, Low AF, Chai P, Lee CH, Yeo TC, Yip J, Tan HC, Mamas MA, Nicholls SJ, Chan MY. Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort. Lancet Reg Health West Pac. 2023 May 31;37:100803. doi: 10.1016/j.lanwpc.2023.100803.

Professional Memberships

Royal College of Physicians, United Kingdom

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