Dr Alvin Wong is a senior consultant in the Dept of Haematology Oncology at the National University Hospital. He leads the medical oncology Genitourinary Cancers team at the National University Cancer Institute, and is actively involved in specialty training, clinical research and patient care.
His recent clinical trial activity includes participation in the global phase III studies in kidney (COSMIC 313, LITESPARK 022), urothelial (EV 302, TROPIC 04), and prostate (PSMAddition) cancers. He also contributed to phase I trials developing novel therapeutics in prostate (Bispecific T cell Engager: AMG 160) and kidney (HIF 2-alpha inhibitor: DFF332) cancers.
He helped develop the Immunotherapy Toxicities (IRTOX) team in NUH, involving cross-specialty collaborations in clinical care and education, and the development of new niche sub-specialties in onco-cardiology and onco-nephrology. He led the NCIS ‘de-Tox’ series of educational webinars.
He enjoys having an eye for what others might miss and goes ‘back to basics’ in clinical acumen to complement modern hi-tech advances. For example, the identification of differential clonal behaviour of different metastatic sites led to his contribution to a paper in Nature/EMBO. He was arguably the first in Singapore to treat and publish a case of life saving chemotherapy given in a pregnant lady with breast cancer.
1. Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression. Chittezhath M, Dhillon MK, Lim JY, Laoui D, Shalova IN, Teo YL, Chen J, Kamaraj R, Raman L, Lum J, Thamboo TP, Chiong E, Zolezzi F, Yang H, Van Ginderachter JA, Poidinger M, Wong AS, Biswas SK. Immunity. 2014 Nov 20;41(5):815-29.
2. Efficacy and Safety of an Attenuated-Dose Sunitinib Regimen in Metastatic Renal Cell Carcinoma: Results From a Prospective Registry in Singapore. Tan HS, Li H, Hong YW, Toh C, Wong A, Lopes G, Tay MH, Chan A, Yao X, Tang T, Ng QS, Kanesvaran R, Chau NM, Tan M. Clin Genitourin Cancer. 2014 Nov 18.
3. Green and black tea intake in relation to prostate cancer risk among Singapore Chinese. Julia A. Montague, Lesley M. Butler, Anna H. Wu, Jeanine M. Genkinger, Woon-Puay Koh, Alvin S. Wong, Renwei Wang, Jian-Min Yuan, Mimi C. Yu. Cancer causes and control 2012 Oct;23(10):1635-41.
4. Cigarette smoking and risk of prostate cancer among Singapore Chinese. Butler LM, Wang R, Wong AS, Koh WP, Yu MC. Cancer Causes and Control 2009 Dec;20(10):1967-74.
5. Calcium intake increases risk of prostate cancer among Singapore Chinese. Lesley M . Butler, Alvin S. Wong, Woon-Puay Koh, Renwei Wang, Jian-Min Yuan, Mimi C. Yu Cancer Res. 2010 Jun 15;70(12):4941-8.
6. Debulking Nephrectomy Followed By A “Watch And Wait” Approach In Metastatic Renal Cell Carcinoma. Wong AS, Chong KT, Heng CT, Consigliere DT, Esuvaranathan K, Toh KL, Chuah B, Lim R, Tan J. Urologic Onoclogy 2009 Mar-Apr;27(2):149-54.
7. Efficacy Of Low Dose Ketoconazole In Hormone Refractory Prostate Cancer Patients At The National Cancer Centre And The Cancer Institute, Singapore Ngo L, Yeo A, Wong AS, Tay MH. Ann Acad Med Singapore. 2007 Oct ;36:811-4.
8. Potential pitfall of FDG PET/CT in assessing residual masses post chemotherapy. Lu JS, Wong AS, Seet JE, Hao C, Sinha A. Clin Nucl Med. 2013 Apr;38(4):e200-4.
9. Targeted Therapy At The End Of Life In Advanced Cancer Patients. T Soh, Yuen YC, C Teo, Lim SW, N Chan, AS Wong.J Palliat Med 2012 Sep;15(9):991-7. Epub 2012 Jul 13.
10. A pregnant lady with aggressive breast cancer. Wong AS, Lim E, Robless PA, Wang SC, Back MF, Ang BK, Lim SE.Ann Acad Med Singapore Jun 2007. Jun;36(6):448-2.
.jpeg)