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Prof Roger Foo

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  • Senior Consultant, Department of Cardiology, National University Heart Centre, Singapore
  • Vice-Dean (Research), Yong Loo Lin School of Medicine, National University of Singapore





Clinical Disciplines/Programmes:

Cardiac Genetics, Cardiology (Heart), Genetic Testing and Specialised Genetic Counselling, Hypertension

Special Interests:

Cardiovascular Epigenetics, Inherited Cardiac Conditions

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Professor Roger Foo is a Senior Consultant cardiologist and is also the Director of Cardiovascular Research Institute (CVRI), National University Heart Centre, Singapore (NUHCS).

He is a graduate, and currently the Vice-Dean (Research) of the Yong Loo Lin School of Medicine, National University of Singapore (NUS) and has nearly 20 years of training and work experience in UK and USA. Prior to his return to Singapore, he was a Research Fellow and Consultant Physician at the University of Cambridge and at Addenbrooke's Hospital, the University teaching hospital at Cambridge. He led a research group of scientists based in the Division of Cardiovascular Medicine, where he continues to hold a Visiting Fellowship. He was a recipient of awards such as the British Cardiac Society Philip White Fellowship, The Wellcome Trust Advanced Research Fellowship and The British Heart Foundation Intermediate Research Fellowship. He was also one of 4 finalists for the Louis N. and Arnold M. Katz Basic Science Research Prize awarded by the Basic Cardiovascular Science Council of the American Heart Association. His laboratory's research focus is Cardiovascular Epigenomics and Epigenetics. This work makes use of human and experimental models of disease, and harnesses a range of genome-wide integrative technology based both at the Cardiovascular Research Institute (CVRI) and the Genome Institute of Singapore (GIS). A/Prof Foo is also a group leader at GIS.

Education and Fellowships:
  • Fellowship, American Heart Association
  • Membership, Basic Cardiovascular Science Council, AHA
  • Membership, British Cardiovascular Society
  • Membership, Royal College of Physicians (UK)
  • British Heart Foundation Intermediate Research Fellowship
  • Wellcome Trust Advanced Research Fellowship
  • British Cardiac Society Philip White Fellowship
  • Specialist Registrar Traineeship, Clinical Pharmacology and Therapeutics, Addenbrooke's Hospital (Cambridge)
  • Research Fellowship, Division of Cardiology, Glenfield Hospital (Leicester)

Journals & Publications

Selected Publications:

  1. Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1. Siggens L, Figg N, Bennett M, Foo R. FASEB J 2012 May ; 26(5) : 2117-24.
  2. The landscape of DNA repeat elements in human heart failure. Haider S, Cordeddu L, Robinson E, Movassagh M, Siggens L, Vujic A, Choy MK, Goddard M, Lio P, Foo R. Genome Biol 2012 Oct 3 ; 13(10) : R90 Epub 2012 Oct 3
  3. Genome-wide DNA methylation in human heart failure. Movassagh M, Vujic A, Foo R. Epigenomics 2011 Feb ; 3(1) : 103-9
  4. Distinct epigenomic features in end-stage failing human hearts. Movassagh M, Choy MK, Knowles DA, Cordeddu L, Haider S, Down T, Siggens L, Vujic A, Simeoni I, Penkett C, Goddard M, Lio P, Bennett MR, Foo RS. Circulation 2011 Nov 29 ; 124(22) : 2411-22 Epub 2011 Oct 24.
  5. The human variome: genomic and epigenomic diversity. Choy M, Movassagh M, Foo R. EMBO Mol Med 2011 Oct ; 3(10) : 573-4 Epub 2011 Aug 3.
  6. Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated. Choy MK, Movassagh M, Goh HG, Bennett MR, Down TA, Foo RS . BMC Genomics. 2010 Sep 27;11:519.
  7. High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure. Choy MK, Movassagh M, Siggens L, Vujic A, Goddard M, Sánchez A, Perkins N, Figg N, Bennett M, Carroll J, Foo R. Genome Med. 2010 Jun 14;2(6):37.
  8. Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure. Movassagh M, Choy MK, Goddard M, Ben nett MR, Down TA, Foo RS. PLoS One. 2010 Jan 13;5(1):e8564.
  9. Regulation of p53 tetramerization and nuclear export by ARC. Foo RS, Nam YJ, Ostreicher MJ, Metzl MD, Whelan RS, Peng CF, Ashton AW, Fu W, Mani K, Chin SF, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, Caldas C, Kitsis RN. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20826-31.
  10. Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. Foo RS, Chan LK, Kitsis RN, Bennett MR. J Biol Chem. 2007 Feb 23;282(8):5529-35.

    For more publications, click here.

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