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Dr Gail Cross

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  • Consultant, Division of Infectious Diseases, Department of Medicine, National University Hospital
  • Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (Monash University), FRACP (Infectious Diseases), BSc (UNSW, 2000)


Infectious Diseases

Clinical Disciplines/Programmes:


Special Interests:

Clinical trials in Infectious Diseases, Host-directed therapies for Infectious Diseases, Tuberculosis, COVID-19, HIV

Find Out More:


Dr. Gail Cross is an Infectious Diseases physician with interest in Tuberculosis, HIV and infections in the immunocompromised host. She graduated with BSc (UNSW, 2000) and MBBS (Monash University, 2006) and was awarded the FRACP (Infectious Diseases) in 2014. She has worked in multiple states in Australia, in Papua New Guinea and currently resides and works in Singapore. Her research interests are primarily in Tuberculosis.

Current Research:

  • Co-Investigator in Rosuvastatin as adjunctive therapy for Drug Susceptible Pulmonary Tuberculosis, a Randomised-Controlled Trial (ROSETTA), National University Hospital.
  • Trial Management Group, Two-month Regimens Using Novel Combinations to Augment Treatment effectiveness for drug-sensitive Tuberculosis (TRUNCATE-TB), National University Hospital.
  • Primary Investigator. COVID-19 responses in the Immunocompromised Host (V-RICH) study
  • Co-Investigator in COVID-19 Serology in Low-Risk patients admitted to hospital with Acute Respiratory Infection, National University Hospital.
  • Co-Investigator in TY0127 trial for patients with COVID-19, NUH
  • Co-Investigator. An untranslated region of the HIV genome predicting for major drug resistance. National University Hospital, Singapore.
  • Collaborator. Topotecan for COVID-19 patients, a Phase II randomised controlled trial, National University Hospital, Singapore.


  • 2019: NUHS Clinician Scientist Programme
  • 2018: AIDS 2018 Scholarship
  • 2018: NLAM Clinician Scientist Unit Pitch for Fund Award
  • 2015: NLAM Clinician Scientist Unit Pitch for Fund Award

Journals & Publications

  1. Philip Kam Wen Kwan, Gail B Cross, Claire M Naftalin, Bintou A. Ahidjo, Chee Keng Mok, Felic Fanusi, Intan Permata Sari, Siok Ching Chia, Shoban Krishna Kumar, Rawan Alagha, Sai Meng Tham, Sophia Archuleta, October M Sessions, Martin I Hibberd, Nicholas I Paton, "A blood RNA transcriptome signature for COVID-19", BMC Medical Genomics. DOI: 10.1186/s12920-021-01006-w. Accepted for publication.
  2. Tay JK, Cross GB, Toh ST, et al. Design and Multicenter Clinical Validation of a 3-Dimensionally Printed Nasopharyngeal Swab for SARS-CoV-2 Testing. JAMA Otolaryngol Head Neck Surg. Published online February 18, 2021. doi:10.1001/jamaoto.2020.5680
  3. Joshua K. Tay, Gail B. Cross, Louisa Sun, Alfred Chia, Jeremy Chee, Jerold Loh, Zhen Yu Lim, Nicholas Ngiam, Khang Wen Pang, Stephanie Yeap, Han Lee Goh, Chor Hiang Siow, 4. Woei Shyang Loh, Kwok Seng Loh, Chun Kiat Lee, Benedict Yan, Vincent T. K. Chow, De Yun Wang, Freddy Boey, John E. L. Wong, David M. Allen. Clinical Diagnostic Study of a Novel Injection Molded Swab for SARS-Cov-2 Testing, Infect Dis Therapy. Dec 11, 2020,
  4. Jinghao Nicholas Ngaim, Nicholas Chew, Sai Meng Tham, Darius Lian-Lian Beh, Zhen Yu Lim, Tony Y.W. Li, Shuyun Cen, Paul Anantharajah Tambyah, Amelia Santosa, Ching-Hui Sia, Gail Brenda Cross. Demographic shift in COVID-19 patients in Singapore from an aged, at-risk population to young migrant workers with reduced risk of severe disease. Int Journal of Infectious Disease. Nov 18, 2020,
  5. N. Bagdasarian, Cross GB, D. Fisher. Rapid publications risk the integrity of science in the era of COVID-19. BMC Med 2020; 18: 192. Published online 2020 Jun 25, doi: 10.1186/s12916-020-01650-6, PMID: 32586327
  6. Archuleta S, Cross GB, Somani J, Lum L, Santosa A, Alagha RA, Allen DM, Ang A, Beh D, Chai L, Chan SM, Lim SM, Olszyna DP, Ong C, Oon J, Salada BMA, Smitasin N, Sun L, Tambyah PA, Tham SM, Yan G, Yee CH, Dan YY, Jureen R, Tee N, Mahadevan M, Yau YW, Quek SC, Liu EH, Sin C, Bagdasarian N, Fisher DA. Responding to COVID-19: how an academic infectious diseases division mobilized in Singapore. BMC Med. 2020 Jun 8;18(1):179. Doi: 10.1186/s12916-020-01641-7.PMID: 32507112
  7. Ong J, Cross GB, Dan YY. Prevention of nosocomial SARS-CoV-2 transmission in endoscopy: international recommendations and the need for a gold standard. Gut. 2020 Jun;69(6):1145-1148. Doi: 10.1136/gutjnl-2020-321154. Epub 2020 Apr 2.PMID: 32241901
  8. Gibney KB, LO Atwood, Nicholson T Tran, J Druce, J Healy, J Strachan, L Franklin, R Hall, Cross GB. Emergence of attenuated measles illness among IgG positive/ IgM negative measles cases, Victoria, Australia 2008 - 2017. Clinical Infectious Diseases, Volume 70, Issue 6, 15 March 2020, Pages 1060-1067,
  9. Cross GB, Benjamin Yeo Chaik Meng, Mark Christopher Tan, Rupangi Verma, Lu Qingshu, Paul Hutchinson, Nicholas I. Paton. Impact of selective immune-cell depletion on growth of Mycobacterium tuberculosis (Mtb)in whole-blood bactericidal activity (WBA) assay. PLoS One. 2019; 14(5): e0216616. Published online 2019 May 17. doi: 10.1371/journal.pone.0216616, PMCID: PMC6524797
  10. Cross GB, Coles K, Nikpour M, Moore OA, Denholm J, McBryde ES, Eisen DP, Warigi B, Carter R, Pandey S, Harino P, Siba P, Coulter C, Mueller I, Phuanukoonnon S, Pellegrini M. TB Incidence and characteristics in the remote gulf province of Papua New Guinea: a prospective study, BMC Infectious Diseases, 14:93, 2014.

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