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University Medicine Cluster

Common Conditions:




High Blood Pressure


High Cholesterol

Chronic Obstructive Pulmonary Disease

Lung Cancer


Obsessive Compulsive Disorder



Hepatitis C


Hepatitis means "inflammation of the liver".


Hepatitis C essentially means an infection with the virus Hepatitis C.




Hepatitis C virus size = 0.000 004cm




Most patients do not have symptoms of hepatitis C, and/or do not feel different from normal.


By the time the symptoms develop, liver damage is usually severe.


It is important to note that the absence of symptoms does not mean hepatitis C or liver damage is under control.


Symptoms of acute infection are:

  • Jaundice
  • Fever
  • Tiredness 


Symptoms of severe liver damage may include:

  • Jaundice
  • A distended, fluid-filled abdomen (ascites)
  • Edema of the legs
  • Small, spider-like veins, usually on the chest and back (spider angiomas)
  • Confusion
  • Bleeding from the gastrointestinal tract



Is this infection common?

There is an estimated 150 million carriers of the hepatitis C virus in the world, with over 500,000 to 750,000 dying annually from HCV-related liver disease.


In Singapore, the prevalence rate is about 0.2%.



What are the complications of Hepatitis C?

Hepatitis C virus does not damage the liver. Liver damage occurs due to the body’s immune system trying to fight the hepatitis C virus. Liver damage can be measured by blood tests such as ALT (also known as SGPT).


If liver damage is prolonged, the liver becomes scarred (liver cirrhosis), which can lead to liver failure, liver cancer and early death.


All these complications are potentially life-threatening.



Who is at risk of Hepatitis C infection?

  • Those who have a past history of blood transfusion, plasma infusions or clotting factor concentrates  before 1990
  • Those with a history of tattoos
  • Household contacts with individuals with hepatitis C
  • Intravenous drugs users
  • Individuals undergoing Hemodialysis
  • Those with a history of dental work
  • Healthcare workers


In Singapore, the majority of hepatitis C patients are intravenous drug users.



How do I know if I have been infected with Hepatitis C?

As hepatitis C is usually asymptomatic, the only way to diagnose hepatitis C is by a simple blood test.


A positive Anti-HCV blood test (antibody to hepatitis C) means contact with the hepatitis C virus. In order to confirm active infection, the HCV RNA test (another blood test) will be conducted. A positive Anti-HCV test but a negative HCV RNA test indicates clearance of an infection with Hepatitis C previously.


A negative anti-HCV test would imply that the person does not have Hepatitis C infection.



How do I prevent myself from being infected with Hepatitis C?

There is no vaccine to prevent hepatitis C infection.


The only method to prevent infection is to avoid risk factors for hepatitis C infection such as tattoos and intravenous drug abuse.



What should I do if I have Hepatitis C?

All persons with Hepatitis C should undergo regular medical follow-up. The purpose of which is to check for liver cancer and any active liver inflammation. In general, most patients require a 6 monthly follow-up. However, if the liver condition is severe or treatment is needed, follow-up sessions may be more frequent. During follow-up, an ultrasound will help to screen for liver cirrhosis and liver cancer. Early detection of liver cancer gives the best chance for cure.


Blood tests should be done routinely and include liver function tests to detect liver inflammation, and alpha fetoprotein for liver cancer.


Patients are advised to avoid alcohol and/or traditional medicines as these substances may cause additional liver damage. Patients should notify their doctors of their hepatitis C and go for routine medical checkups.



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Appointment and Enquiry

University Digestive Centre

Kent Ridge Wing Level 4

National University Hospital


Appointment Lines:
(65) 6772 2505 / (65) 6773 3380
Fax : (65) 6774 1075


Opening Hours: 8.30am - 5.00pm
Closed on Sat, Sun & Public Holiday