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Home > Medical Professionals & Students > Research > Infectious Diseases

Infectious Diseases





Our division focuses its main clinical research activities on the following areas:


1. Infection control emphasizing MRSA and Hand Hygiene
2. Metabolic aspects of HIV infection
Immunology and Management of Opportunistic Infections 
4. Influenza


We take a multi-faceted approach to better manage our patients. We do so by synergising and applying the knowledge we've gained. This is done in close collaboration with our colleagues from the Departments of Haematology, Oncology and Microbiology. While these are our areas of focus, there is regular activity in other relevant areas as well.

Beyond NUH, we have collaborations across Singapore with other hospitals, research organizations and the National University of Singapore (NUS).


Clinical Trials:

Adult Dengue Platelet Study (ADEPT)

The Chloroquine for Influenza Prevention Trial (CHIP)

Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore (CYD28)


Microbiology Department: 

The research team comprises medical microbiologists, scientific officer, medical technologists and research assistants. They combine duties in providing a clinical laboratory service with scientific investigation to enhance the value of their work and to help in understanding the changing nature of pathogens. The laboratory also supervises graduate students both locally and from abroad, as well as offer projects to polytechnic students. We provide diagnostic support to the ID Division to support clinical trials and the investigation of new infectious syndromes.


For more information on Microbiology Laboratory, please click here.




Antibiotics for Klebsiella Liver Abscess Study (A-KLASS)


The Antibiotics for Klebsiella Liver Abscess Study (A-KLASS), is a multi-centre randomised open-label active comparator controlled non-inferiority trial comparing the efficacy of early oral administration of antibiotics with intravenous administration of antibiotics in the early management of Klebsiella pneumoniae liver abscess.


Currently, there is wide variation in clinical practice regarding the best time to step down to oral therapy for Klebsiella Liver Abscess. The results of this study will provide an evidence base for local and international guidelines.


This study is made possible by a combination of National Medical Research Council (NMRC) and Singapore Infectious Diseases Initiative (SIDI) funding, and the support of the Singapore Clinical Research Institute (SCRI). Recruitment began in October 2013 and will be completed by the end of 2016. The study is taking place at three sites: National University Hospital, Tan Tock Seng Hospital and Singapore General Hospital.


The protocol has been published in Trials Journal and the study was featured as a Key Project in SCRI’s 2013 Annual Report. Preliminary data was presented at ID Week 2015.

Singapore Programme of Research Investigating New Approaches to Treatment of Tuberculosis










SPRINT-TB (Singapore Programme of Research Investigating New Approaches to Treatment of Tuberculosis) is a comprehensive bench-to-bedside tuberculosis (TB) research programme led by National University of Singapore. The programme commenced in 2014 upon the award of the TCR Flagship grant by National Medical Research Council (NMRC), Singapore.



The programme performs integrated research across all steps in the process of TB drug development through to delivery to the patients in need. SPRINT-TB research spans four interconnected research themes which integrate over thirty ongoing projects:



Theme 1: Target Discovery


Lead: A/Prof. Thomas Dick

Department of Microbiology and Immunology, NUS


Using genetic and chemical approaches to identify new mycobacterial targets.


Theme 2: Drug Development


Lead: Prof. Alex Matter

Experimental Therapeutics Centre, A*STAR


Conducting screening, medicinal chemistry and pharmacology studies to develop new TB drug candidates.


Theme 3: Clinical Trials


Lead: Prof. Nicholas Paton

Department of Medicine, NUS



Conducting clinical trials to evaluate safety and efficacy of new drugs and combination regimens for TB.


Theme 4: Treatment Delivery


Lead: Prof. Richard Coker,

Saw Swee Hock School of Public Health, NUS


Developing solutions to the individual and systemic barriers that hinder successful provision of effective combination therapy.


For more information, click here