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Dr Yi Ann Louis Chai

  • Senior Consultant, Division of Infectious Diseases, Department of Medicine, National University Hospital
MBBS(S'pore), MRCP (UK), Specialist Accreditation in Infectious Disease, PhD (Nijmegen, The Netherlands)
Infectious Diseases


Professional Experience:
2009 - Now Consultant, Infectious Diseases Physician, Department Of Medicine, National University Hospital, Singapore
2007 – 2010 Fellow, Department Of Internal Medicine, Radboud,University Nijmegen Medical Center, The Netherlands
2006 – 2008 Associate Consultant & Infectious Diseases Physician, Department Of Medicine, National University Hospital
2003 – 2006 Registrar, Department Of Medicine,NationalUniversityHospital
Nov 02 - Aug 03 Medical Officer, Dept Of Medicine, National University Hospital
May 02 - Oct 02 Medical Officer, Accident & Emergency Department,Changi General Hospital
Nov 01 - Apr 02 Medical Officer, Dept OfHaematology,Singapore General Hospital
May 01 - Oct 01 Medical Officer, Dept Of Medicine, National University Hospital
Medical Officer, Dept Of Cardiology, National Heart Centre
Dec 99 - Mar 01 Head, Diving Medicine Branch, Naval Medicine And Hyperbaric Centre, Republic Of Singapore Navy Medical Service
May 99 - Mar 01 Medical Officer, Singapore Armed Forces
Nov 98 - Apr 99 Medical Officer, Dept Of Neonatology, Kandang Kerbau Women's And Children's Hospital
May 98 - Oct 98 Medical Officer, Dept Of Respiratory And Critical Care Medicine, Singapore General Hospital
Jan 98 - Apr 98 House Officer, Dept Of Paediatric Medicine, Kandang Kerbau Women's And Children's Hospital
Sep 97 - Dec 97 House Officer, Dept Of General Medicine, Tan Tock Seng Hospital
May 97 - Aug 97 House Officer, Dept Of General Surgery, Tan Tock Seng Hospital

Professional Positions & Memberships
2003 – Now Clinical tutor, National University of Singapore
2003 – 2005 Part-time clinical tutor, MRCP (UK) exams preparation
2004 – 2008 Member, Society of Infectious Disease (Singapore)
2005 – 2006 Secretary, Society of Infectious Disease (Singapore)
2005 Member, Australian Society of Infectious Disease
2004 – 2005 Member, Singapore Candidemia Guidelines Workgroup
2006, 2009 Member, American Society of Microbiology
2008 – 2010 Member, European Society of Clinical Microbiology and Infections Diseases

Journals & Publications

  1. The Y238X stop codon polymorphism in the human beta-glucan receptor dectin-1 and susceptibility to invasive aspergillosis.
  2. Chai LY, de Boer MG,  van der Velden WJ, Plantinga TS, van Spriel AB, Jacobs C, Constantijn JM, Vonk AG, Blijlevens NM, van Dissel JT, Donnelly P, Kullberg BJ,. Maertens J, Netea MG.
  3. J Infect Dis, 2011 (in press)
  4. 1,25-dihydroxyvitamin D3 Modulates Cytokine Production Induced by Candida albicans: Impact of Seasonal Variation of Immune Responses.
  5. Khoo AL, Chai LY, Koenen H, Joosten I, van der Ven AJM, Netea MG.
  6. J Infect Dis 2011; 203:122-30
  7. Immune response to Aspergillus in compromised hosts: from bedside to bench
  8. Chai LY, Vonk AG, Kullberg BJ, Netea MG
  9. Future Microbiol 2011; 6:73-83
  10. Early proinflammatory cytokines and C-reactive protein  trends as predictors of outcome in invasive aspergillosis
  11. Chai LY, Netea MG, Teerenstra S, Earnest A, Vonk AG, Schlamm HT, Troke PF, Kullberg BJ.
  12. J Infect Dis 2010; 202:1454-62
  13. Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses.
  14. Chai LY, Vonk AG, Kullberg BJ, Verweij PE, Verschueren I, van der Meer JW, Joosten LA, Latge JP, Netea MG.
  15. Microbes Infect 2010 [epub Nov 2]
  16. Candida tropicalis and human disease
  17. Chai LY, Denning D, Warn P
  18. Crit Rev Microbiol 2010; 36: 282-98
  19. Anti-Aspergillus human host defense relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity
  20. Chai LY, van de Veerdonk F, Marijnissen RJ, Cheng SC, Khoo AL, Hectors M, Lagrou K, Vonk AG, Maertens J, Joosten LA, Kullberg BJ, Netea MG.
  21. Immunology 2010; 130: 46-54
  22. Candida albicans releases soluble factors that potentiate cytokine production by human cells through a protease-activated receptor 1- and 2-independent pathway
  23. Cheng SC, Chai LY, Joosten LA, Vecchiarelli A, Hube B, Van Der Meer JW, Kullberg BJ, Netea MG.
  24. Infect Immun. 2010; 78: 393-9
  25. Aspergillus fumigatus conidial melanin down-regulates host cytokine response
  26. Chai LY, Netea MG, Sugui J, Vonk AG, van de Sande WW, Warris A, Kwon-Chung KJ, Jan Kullberg B.
  27. Immunobiology 2010; 215: 915-20
  28. Modulation of TLR2 and TLR4 Responses by Aspergillus fumigatus
  29. Chai LY, Kullberg BJ, Vonk AG, Warris A, Cambi A, Latgé JP, Joosten LA, van der Meer JW, Netea MG.
  30. Infect Immun. 2009; 77: 2184-92


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