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Dr Thomas Paulraj Thamboo

  • Senior Consultant, Department of Pathology, National University Hospital
  • Assistant Professor, Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore
MBChB (Leeds), FRCPA, FRCPath
Special Interests:
Renal pathology, Urologic pathology


Dr Thomas Thamboo is a Senior Consultant Pathologist in NUH. He graduated from the medical school at the University of Leeds, United Kingdom in 1995. He trained in histopathology at the Department of Pathology, National University of Singapore, and obtained his specialist qualifications in histopathology from both the Royal College of Pathologists (United Kingdom) and the Royal College of Pathologists of Australasia in 2004. He undertook sub-specialty training in renal pathology at the department of cellular pathology at John Radcliffe Hospital, Oxford, United Kingdom in 2006.

He has authored or co-authored more than 75 papers in peer-reviewed journals. He is actively involved in general histopathology and cytopathology reporting, with sub-specialty reporting of urologic pathology and renal pathology cases. He is also currently the Programme Director of the Pathology ACGME-I Residency Programme.

Journals & Publications

  1. Nai YH, Cheong DLH, Roy S, Kok T, Stephenson MC, Schaefferkoetter J, Totman JJ, Conti M, Eriksson L, Robins EG, Wang Z, Chua WY, Ang BWL, Singha AK, Thamboo TP, Chiong E, Reilhac A. Comparison of quantitative parameters and radiomic features as inputs into machine learning models to predict the Gleason score of prostate cancer lesions. Magnetic Resonance Imaging 2023 Jul; 100: 64-72.
  2. So WZ, Teo RZC, Ooi LY, Goh BYS, Lu J, Vathsala A, Thamboo TP, Tiong HY. Multi-Photon Microscopy for the Evaluation of Interstitial Fibrosis in Extended Criteria Donor Kidneys: A Proof-of-Concept Study. Clin Transplant. Clinical Transplantation 2022 Aug; 36(8):e14717
  3. Tan Z, Mok MMH, Soe WM, Thamboo TP, Goh JG, Qi Hui Sam, Osato M, Ravikumar S, Chai LYA. Tocilizumab Induces Immune Tolerance in Invasive Candidiasis. Journal of Fungi (Basel) 2021 Aug; 7(8): 656.
  4. Lee SH, Mahendran R, Tham SM, Thamboo TP, Chionh BJ, Lim YX, Tsang WC, Wu QH, Chia JY, Tay MHW, Goh BYS, Chen KW, Mallari JZ, Periaswami R, Raman L, Choo SN, Kioh DYQ, Chiong E, Esuvaranathan K, Chan ECY. Tryptophan-kynurenine ratio as a biomarker of bladder cancer. BJU Int. 2021 Apr;127(4):445-453.
  5. Lee SH, Mahendran R, Tham SM, Thamboo TP, Kioh DYQ, Tang LWT, Chiong E, Esuvaranathan K, Chan ECY. Combination Bacillus Calmette–Guérin and indoleamine 2,3-dioxygenase 1 inhibitor therapy of murine orthotopic bladder cancer. BJU Int. 2020 Nov;126(5):554-556.
  6. Tan YQ, Tay WK, Ooi LY, Thamboo TP, Tiong HY. Multiphoton microscopic study of the renal cell carcinoma pseudocapsule: Implications for tumour enucleation. Urology 2020 Oct; 144: 249-254.
  7. Chang ZY, Thamboo TP, Choong CSH, Wong WK, Ngoh CLY. Multiple myeloma-associated light chain amyloidosis and a proposed approach to monoclonal immunoglobulin-associated renal disease. Case Rep Nephrol Dial. 2020 Sep 11;10(3):95-103.
  8. Khoo BL, Bouquerel C, Durai P, Anil S, Goh B, Wu B, Raman L, Mahendran R, Thamboo T, Chiong E, Lim CT. Detection of Clinical Mesenchymal Cancer Cells from Bladder Wash Urine for Real-Time Detection and Prognosis. Cancers (Basel) 2019; 11(9): 1274.
  9. Celhar T, Lu HK, Benso L, Rakhilina L, Lee HY, Tripathi S, Zharkova O, Ong WY, Yasuga H, Bjin A, Marlier D, Lim, LHS, Thamboo TP, Mudgett JS, Mackey MF, Zaller DM, Connolly JE, Fairhurst AM. TLR7 protein expression in mild and severe lupus-prone models is regulated in a leukocyte, genetic and IRAK4 dependent manner. Frontiers in Immunology 2019; 10: 1546.
  10. Mak A, Dharmadhikari B, Kow NY, Thamboo T, Tang Q, Wong LW, Sreedharan SK, Schwarz H. Deletion of CD137 ligand exacerbates renal and cutaneous but alleviates cerebral manifestations in lupus. Frontiers in Immunology 2019; 10: 1411.


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