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Dr Mariflor Villegas

Photo of Dr Mariflor Villegas
BS Biology (Phil), MD (Phillippines), Dip (Paeds Cancer Care) (S'pore)
Resident Physician II, Division of Paediatric Haematology and Oncology, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital

Asst Quality Officer, Paediatric Oncology and Blood / Marrow Transplantation (BMT) Programme [FACT accredited programme], National University Hospital
Sub Specialty:
Paediatric Blood and Marrow Transplantation (BMT) Programme, Paediatric Haematology-Oncology
Medical and Surgical Conditions:
Cell-based Therapy, Childhood Cancer, Childhood Leukaemia, Immunodeficiency Disease, Langerhan Cell Histiocytosis, Neuroblastoma
Special Interest:
  • Paediatric Blood / Marrow Transplant & Cell Therapy
  • Paediatric Hematologic Malignancies
  • Paediatric Immunodeficiency Diseases & HLH
  • International Outreach

National University Hospital
National University Cancer Institute, Singapore
National University Health System
  • Clinical Experience
  • Hospital Credentialed for Allogeneic and Autologous Hematopoietic Stem Cell Transplantation and Bone Marrow Harvest (2014)
  • Senior Clinical Fellow, Pediatric Blood/Marrow Transplantation (NUH, Singapore 2010-2011)
  • Clinical Fellow, Pediatric Hematology/Oncology (NUH, Singapore 2003-2007)

Awards and Honours

International Union against Cancer (UICC) Technology Transfer Fellowship (St Jude Children’s Research Hospital Memphis, Tennessee, USA, 2007)

Professional Memberships

​VIVA-Asia Blood/ Marrow Transplant Consortium (VABMT)

Research and Publications

Selected Publications:
  1. Liu ID, Tan PL, Tan CX, Isa MS, Lau PY, Yeo WS, Chaturvedi S, Villegas MS, Ng KH, Yap HK, Ng SB. Metachronous B-cell and T-cell post-transplant lymphoproliferative disorders with features of chronic active Epstein-Barr virus infection. Am J Hematol. 2015 Jul 15. doi: 10.1002/ajh.24122
  2. PL Tan, LM Lim, C Khan Lian, MS Villegas. A single Center experience of cytomegalovirus. infections in Asian Pediatric patients undergoing allogeneic hematopoietic transplant for leukemia in Singapore. Transplant Infectious Diseases 2014 0;1-5.
  3. BMT Guidebook: guide for patients, 2014 1st ed.
  4. Chen J, Lee V, Luo CJ, Chiang AK, Hongeng S, Tan PL, Tan AM, Sanpakit K, Li CF, Lee AC, Chua HC, Okamoto Y. Allogeneic stem cell transplantation for children with acquired severe aplastic anaemia: a retrospective study by the Viva-Asia Blood and Marrow Transplantation Group. Br J Haematol. 2013 Aug;162(3):383-91. doi: 10.1111/bjh.12405. Epub 2013 Jun 5.
  5. Orientation Handbook for Pediatric Hematology/Oncology/BMT Rotation Junior Doctors. December 2010, Rev April 2013.
  6. Lee AJ; Wu J; Villegas MS; Shek LPC; Lee BW; Tan PL. Stem Cell Transplantation for Primary Immunodeficiency Disease: Experience of a Singapore Hospital. World Allergy Organization Journal 2012;5:41-44.
  7. Lin DY, Villegas MS, Tan PL, Wang S, Shek LP. Severe Kikuchi's disease responsive to immune modulation. Singapore Med J. 2010 Jan; 51(1):e18-21.

Selected Scientific Publications:
  1. Establishing a Hematopoietic Stem Cell Transplant Late-Effects Programme for Local and Regional Patients in a Single Center in Singapore. Cing KL, Mariflor Villegas, Tan PL, Doris Tan, Evelyn Goh Joy DC .Singapore20th Congress of the Asia Pacific Blood and Marrow Transplantation Okinawa, Japan. 29-31 October 2015.
  2. Mariflor S. Villegas, Cing Khan Lian Poh-Lin Tan. Response to immunization with hepatitis B, varicella, measles, mumps and rubella in pediatric patients after hematopoietic stem cell transplantation. 41st Annual Meeting of the European Group for Blood and Marrow Transplantation, 22 to 25 March, Istanbul - Turkey.
  3. MS Villegas, WL Seo, HS Chua, TC Quah, A Yeoh and PL Tan. Fludarabine, Busulfan and Melphalan Conditioning in Pediatric Myeloid Malignancies Undergoing Hematopoietic Stem Cell Transplantation. 40th Annual Meeting of the European Group for Blood and Marrow Transplantation, Milan, Italy, 30 March -2 April.
  4. MS Villegas, HS Chua, SH Quak, M Aw, PL Tan. Diagnostic Utility of Endoscopy in Gastrointestinal Graft-versus-Host Disease After Paediatric Blood and Marrow Transplantation. 39th Annual Meeting of the European Group for Blood and Marrow Transplantation, London, UK, 7 April -10April 2013.
  5. PL Tan, MS Villegas, SP Chen, TG Soh, P Law, R Tan, M Yawata, EC Smith, D Campana. Treatment of Refractory Acute Myeloid Leukaemia with Alloreactive Natural Killer Cell Conditioning Followed by 2Gy TBI and Stem Cell Transplant. 39th Annual Meeting of the European Group for Blood and Marrow Transplantation, London, UK, 7April -10April 2013.
  6. ZJ Goh, SL Low, C Khan Lian, NDBM Ismail, HC Chua, MS Villegas, YS Lee, PL Tan. Bone Health in Children and Adolescents Undergoing Hematopoietic Cell Transplantation in a Singapore Center. 2012 BMT Tandem Meetings, San Diego, California, USA, Feb 1 – 5, 2012.
  7. MS Villegas, HC Chua, A Yeoh, TC Quah, PL Tan. Evolving Indications for Stem Cell Transplantation over Three Decades. 14th ASEAN Paediatric Congress 2011, Singapore, 15 – 17 April 2011.
  8. PL Tan, HC Chua, MS Villegas, A Yeoh, TC Quah. HLA Matching at DNA Level and its Impact on the Outcome of Pediatric Transplants for Leukemia in Multi-Racial Singapore. 2011 BMT Tandem Meetings, Honolulu, Hawaii, USA, Feb 17 – 21, 2011