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Dr Joshua Tay Kai Xun

Photo of Dr Joshua Tay Kai Xun
  • Consultant, Department of Otolaryngology - Head & Neck Surgery (ENT), National University Hospital
MBBS(S’pore), PhD(Stanford), MRCS(Glasgow), MMed(ORL), FAMS
Otolaryngology - Head & Neck Surgery (ENT)
Special Interests:
​Head and Neck Cancers Genetic Research


Dr Joshua Tay graduated from the Faculty of Medicine, National University of Singapore in 2007. He completed his residency training in Otolaryngology – Head & Neck Surgery in Singapore and was awarded the College of Surgeons Gold Medal for the best performance at the Otolaryngology exit examinations in 2015.

Dr Tay was awarded the Ministry of Health Healthcare Research Scholarship, during which he completed a PhD in Cancer Biology at the Stanford University School of Medicine focusing on molecular subtypes of nasopharyngeal cancer, under the guidance of Professors John B. Sunwoo and Robert B. West. Dr Tay’s research interest involves classifying tumors based on their gene signatures and matching them with targeted therapies for personalized treatment.

He is currently a Consultant at the Department of Otolaryngology – Head & Neck Surgery. In his clinical practice, Dr Tay sees patients with general Ear, Nose and Throat conditions, as well as patients with nasopharyngeal cancer.


2019 - Poster Award Presentation - Others (The 6th NCIS Annual Research Meeting (NCAM) 2019)

Best Poster (Clinical Science), NCIS Annual Meeting, 2019

Outstanding Poster Award, Gordon Research Conference on NPC, 2018

College of Surgeons Gold Medal, 2016

Journals & Publications

  1. ​Tay JK, Khoo ML, Loh WS.  Surgical Considerations for Tracheostomy During the COVID-19 Pandemic: Lessons Learned From the Severe Acute Respiratory Syndrome Outbreak.  JAMA Otolaryngol Head Neck Surg. 2020 Jun 1;146(6):517-518. doi: 10.1001/jamaoto.2020.0764.
  2. Barbier V, Erbani J, Fiveash C, Davies JM, Tay J, Tallack MR, Lowe J, Magnani JL, Pattabiraman DR, Perkins AC, Lisle J, Rasko JEJ, Levesque JP, Winkler IG.  Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.
    Nat Commun. 2020 Apr 27;11(1):2042. doi: 10.1038/s41467-020-15817-5.
  3. Kobayashi T, Lam PY, Jiang H, Bednarska K, Gloury R, Murigneux V, Tay J, Jacquelot N, Li R, Tuong ZK, Leggatt GR, Gandhi MK, Hill MM, Belz GT, Ngo S, Kallies A, Mattarollo SR.  Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.
    Blood. 2020 Dec 24;136(26):3004-3017. doi: 10.1182/blood.2020005602.
  4. Tay JK, Khoo ML, Loh WS.  Tracheostomy During COVID-19 Pandemic-In Search of Lost Timing-Reply.
    JAMA Otolaryngol Head Neck Surg. 2020 Sep 3. doi: 10.1001/jamaoto.2020.2633
  5. Tay JK, Lim WS, Loh WS, Loh KS.  Sustaining Otolaryngology Services for the Long Haul during the COVID-19 Pandemic: Experience from a Tertiary Health System.
    Otolaryngol Head Neck Surg. 2020 Jul;163(1):47-50. doi: 10.1177/0194599820922983. Epub 2020 May 5.
  6. Chong WQ, Lim CM, Sinha AK, Tan CS, Chan GHJ, Huang Y, Kumarakulasinghe NB, Sundar R, Jeyasekharan AD, Loh WS, Tay JK, Yadav K, Wang L, Wong AL, Kong LR, Soo RA, Lau JA, Soon YY, Goh RM, Ho FCH, Chong SM, Lee SC, Loh KS, Tai BC, Lim YC, Goh BC.  Integration of Antiangiogenic Therapy with Cisplatin and Gemcitabine Chemotherapy in Patients with Nasopharyngeal Carcinoma.  Clin Cancer Res. 2020 Oct 15;26(20):5320-5328. doi: 10.1158/1078-0432.CCR-20-1727. Epub 2020 Aug 14.
  7. Lechner M, Schartinger VH, Steele CD, Nei WL, Ooft ML, Schreiber LM, Pipinikas CP, Chung GT, Chan YY, Wu F, To KF, Tsang CM, Pearce W, Morelli D, Philpott M, Masterson L, Nibhani R, Wells G, Bell CG, Koller J, Delecluse S, Yip YL, Liu J, Forde CT, Forster MD, Jay A, Dudás J, Krapp A, Wan S, Uprimny C, Sprung S, Haybaeck J, Fenton TR, Chester K, Thirlwell C, Royle G, Marafioti T, Gupta R, Indrasari SR, Herdini C, Slim MAM, Indrawati I, Sutton L, Fles R, Tan B, Yeong J, Jain A, Han S, Wang H, Loke KSH, He W, Xu R, Jin H, Cheng Z, Howard D, Hwang PH, Le QT, Tay JK, West RB, Tsao SW, Meyer T, Riechelmann H, Oppermann U, Delecluse HJ, Willems SM, Chua MLK, Busson P, Lo KW, Wollmann G, Pillay N, Vanhaesebroeck B, Lund VJ.  Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.  Nat Commun. 2021 Jan 5;12(1):117. doi: 10.1038/s41467-020-20308-8.
  8. Zhou S, Huang H, Chen Q, Tan KS, Zhu Z, Peng Y, Ong HH, Liu J, Xu M, Gao J, Chen H, Tay JK, Qiu Q, Wang DY.  Long-term defects of nasal epithelium barrier functions in patients with nasopharyngeal carcinoma post chemo-radiotherapy.
    Radiother Oncol. 2020 Jul;148:116-125. doi: 10.1016/j.radonc.2020.03.038. Epub 2020 Apr 6.
  9. Bier-Laning C, Cramer JD, Roy S, Palmieri PA, Amin A, Añon JM, Bonilla-Asalde CA, Bradley PJ, Chaturvedi P, Cognetti DM, Dias F, Di Stadio A, Fagan JJ, Feller-Kopman DJ, Hao SP, Kim KH, Koivunen P, Loh WS, Mansour J, Naunheim MR, Schultz MJ, Shang Y, Sirjani DB, St John MA, Tay JK, Vergez S, Weinreich HM, Wong EWY, Zenk J, Rassekh CH, Brenner MJ.  Tracheostomy During the COVID-19 Pandemic: Comparison of International Perioperative Care Protocols and Practices in 26 Countries.
    Otolaryngol Head Neck Surg. 2020 Nov 3:194599820961985. doi: 10.1177/0194599820961985
  10. Erbani J, Tay J, Barbier V, Levesque JP, Winkler IG.  Acute Myeloid Leukemia Chemo-Resistance Is Mediated by E-selectin Receptor CD162 in Bone Marrow Niches.
    Front Cell Dev Biol. 2020 Jul 24;8:668. doi: 10.3389/fcell.2020.00668. eCollection 2020.

Professional Memberships

Academy of Medicine, Singapore

Royal College of Physicians and Surgeons, Glasgow