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Prof Jimmy So

Photo of Prof Jimmy So
  • Head & Senior Consultant, Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery, National University Hospital
  • Head & Senior Consultant, Division of Surgical Oncology, National University Cancer Institute, Singapore
  • Professor of Surgery, Yong Loo Lin School of Medicine, National University of Singapore (NUS)
Surgical Oncology (Upper Gastrointestinal Surgery), Upper Gastrointestinal Surgery
Special Interests:
Surgical oncology and minimal invasive surgery for gastric and esophageal cancer , Diagnostic and therapeutic upper endoscopy , Bariatric surgery for morbid obesity , Surgery for gastroesophageal reflux and achalasia , Gastric cancer: carcinogenesis, biomarker, diagnosis & therapy (click here for more details) , Esophageal cancer , Obesity and metabolic syndrome , Diagnostic and therapeutic endoscopy


Prof Jimmy So graduated from Faculty of Medicine at the Chinese University of Hong Kong in 1991. He received his surgical training in National University Hospital, Singapore. He was trained in Upper Gastrointestinal Surgery, Surgical Oncology, Bariatric Surgery, Therapeutic Endoscopy and Minimally Invasive Surgery. He received fellowship training at Massachusetts General Hospital, Harvard Medical School, USA. He was also appointed as visiting consultant surgeon in Esophageal and Gastric Surgery at the Royal Infirmary in Edinburgh, Scotland, UK. He established a multidisciplinary program for Esophageal and Gastric cancers in NUH in 2005. He also received fellowship training in gastric and esophageal cancer surgery in Japan, Korea and Hong Kong. He is the pioneer in endoscopic surgery for early esophageal and gastric cancers, robotic surgery and Peroral Endoscopic Myotomy (POEM) for Achalasia in Singapore.

Prof Jimmy So’s special interests are in gastric cancer, esophageal cancer and obesity. He has published more than 140 peer reviewed scientific papers and received many research grants for his research work in these areas. He received a Gold Award at the annual scientific meeting of the National Healthcare Group. He was invited regularly to speak at International Gastric Cancer Congress, Annual Scientific Meetings of Japanese Gastric Cancer Association and Korean International Gastric Cancer Week. He has also presented his works at American Gastroenterological Association (AGA), American Society of Gastrointestinal Endoscopy (ASGE), Society of American Gastrointestinal Endoscopic Surgeons (SAGES), and World Congress of Endoscopic Surgery.

He is founding president of the Asia-Pacific Gastro-esophageal Cancer Congress in 2006. In 2013, he was the council member of the Consensus Meeting at the 10th International Gastric Cancer Congress, held at Verona, Italy. He is also a founding member of Asia-Pacific Bariatric Surgery Society. Prof So is a member of editorial board of medical journals such as Gastric Cancer, Journal of Gastric Cancer and Translational Medicine. He is a reviewer for a number of prestigious medical journals including New England Journal of Medicine, British Journal of Surgery, Annals of Surgical Oncology, Surgical Endoscopy and Digestive Disease and Science. Presently, he is actively involved in management of patients with gastric and esophageal cancers, morbid obesity and other Upper GI disorders.

Professional Highlights
Chairman, Organising Committee, Asia-Pacific Gastric Cancer Congress in 2006, 2012
Chairman, Organising Committee, GIST Tour 2011
Chairman, Organising Committee, Gastric Cancer Awareness Month, Singapore Cancer Society
Executive Committee, Singapore Gastric Cancer Consortium (SGCC)


Laureate of the Peritoneum Prize 2020
Best Doctor Award at the Annual Scientific Congress of National Healthcare Group, 2208 for research work on Endoscopic Imaging for Gastric Cancer
Young Surgeon Award, Academy of Medicine

Journals & Publications

  1. Roux-en-Y or Billroth II Reconstruction After Radical Distal Gastrectomy for Gastric Cancer: A Multicenter Randomized Controlled Trial. So JB, Rao J, Wong AS, Chan YH, Pang NQ, Tay AY, Yung MY, Su Z, Phua JN, Shabbir A, Ng EK. Annals of Surgery. 2017 Apr 5. doi: 10.1097/SLA.0000000000002229. PMID: 28383294
  2. Extensive peritoneal lavage after curative gastrectomy for gastric cancer (EXPEL): study protocol of an international multicentre randomised controlled trial. Kim G, Chen E, Tay AY, Lee JS, Phua JN, Shabbir A, So JB, Tai BC. Japanese journal of clinical oncology. 2017 Feb 26;47(2):179-184. doi: 10.1093/jjco/hyw153. PMID: 28173154
  3. Conversion Surgery Post-Intraperitoneal Paclitaxel and Systemic Chemotherapy for Gastric Cancer Carcinomatosis Peritonei. Are We Ready?Chan DY, Syn NL, Yap R, Phua JN, Soh TI, Chee CE, Nga ME, Shabbir A, So JB, Yong WP. Journal of Gastrointestinal Surgery. 2017 Mar;21(3):425-433. doi: 10.1007/s11605-016-3336-3. Epub 2016 Dec 15. PMID:27981493
  4. Intraperitoneal chemotherapy for gastric cancer with peritoneal disease: experience from Singapore and Japan.;Kono K, Yong WP, Okayama H, Shabbir A, Momma T, Ohki S, Takenoshita S,So J. Gastric cancer. 2017 Mar;20(Suppl 1):122-127. doi:;10.1007/s10120-016-0660-y. Epub 2016 Oct 20. Review. PMID: 27766496
  5. Accumulation of CD11c+CD163+ Adipose Tissue Macrophages through Upregulation of Intracellular 11β-HSD1 in Human Obesity. Nakajima S, Koh V, Kua LF,So J, Davide L, Lim KS, Petersen SH, Yong WP, Shabbir A, Kono K. The Journal of Immunology. 2016 Nov 1;197(9):3735-3745. Epub 2016 Oct 3. PMID: 27698011
  6. ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VH, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Zhu F, So JB, Teh BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L. Gastroenterology. 2016 Oct;151(4):637-650.e10. doi: 10.1053/j.gastro.2016.06.043. Epub 2016 Jul 1. PMID:27373511
  7. Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice. Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y. Gastroenterology. 2017 Jan;152(1):218-231.e14. doi: 10.1053/j.gastro.2016.09.018. Epub 2016 Sep 23.PMID: 27670082
  8. Is Elective Gastroscopy Prior to Bariatric Surgery in an Asian Cohort Worthwhile? Ng JY, Cheng AKS, Kim G, Kong LWC, Soe KT, Lomanto D, So JBY, Shabbir A. Obesity surgery. 2016 Sep;26(9):2156-2160. doi: 10.1007/s11695-016-2060-0. PMID: 26780361
  9. Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma. Huang B, Deng S, Loo SY, Datta A, Yap YL, Yan B, Ooi CH, Dinh TD, Zhuo J, Tochhawng L, Gopinadhan S, Jegadeesan T, Tan P, Salto-Tellez M, Yong WP, Soong R, Yeoh KG, Goh YC, Lobie PE, Yang H, Kumar AP, Maciver SK, So JB, Yap CT. Oncotarget. 2016 May 3;7(18):25391-407. doi: 10.18632/oncotarget.8603. PMID:27058427
  10. Goal-directed program after sleeve gastrectomy improves weight loss. Kim G, Tan CS, Ng JY, Cheng AK, Rao J, Soe KT, Kong LW, Naseer F, Er PS, Lomanto D, So JB, Shabbir A. Surgery for obesity and related diseases.2016 Mar-Apr;12(3):518-21. doi: 10.1016/j.soard.2015.11.014. Epub 2015 Nov 19. PMID:26944549
  11. Effect of weight loss after bariatric surgery on kidney function in a multiethnic Asian population. Ngoh CL, So JB, Tiong HY, Shabbir A, Teo BW. Surgery for obesity and related diseases. 2016 Mar-Apr;12(3):600-5. doi: 10.1016/j.soard.2015.07.003. Epub 2015 Jul 9. PMID: 26522229
  12. Early outcomes of laparoscopic sleeve gastrectomy in a multiethnic Asian cohort. Ching SS, Cheng AK, Kong LW, Lomanto D, So JB, Shabbir A. Surgery for obesity and related diseases. 2016 Feb;12(2):330-7. doi: 10.1016/j.soard.2015.05.009. Epub 2015 May 22. PMID:26363715
  13. Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas. Lin SJ, Gagnon-Bartsch JA, Tan IB, Earle S, Ruff L, Pettinger K, Ylstra B, van Grieken N, Rha SY, Chung HC, Lee JS, Cheong JH, Noh SH, Aoyama T, Miyagi Y, Tsuburaya A, Yoshikawa T, Ajani JA, Boussioutas A, Yeoh KG, Yong WP, So J, Lee J, Kang WK, Kim S, Kameda Y, Arai T, Zur Hausen A, Speed TP, Grabsch HI, Tan P. Gut. 2015 Nov;64(11):1721-31. doi: 10.1136/gutjnl-2014-308252. Epub 2014 Nov 10. PMID: 25385008
  14. Submucosal carcinoma of the gastroesophageal junction diagnosed after peroral endoscopic myotomy. Chan DY, Dolgunov D, Lee VK, Chiu PW, So JB. Endoscopy. 2015;47 Suppl 1:E623-4. doi: 10.1055/s-0034-1393591. Epub 2015 Dec 29. PMID: 26714153
  15. Removal of a large, 40-mm, submucosal leiomyoma using submucosal tunneling endoscopic resection and extraction of specimen using a distal mucosal incision. Ng JJ, Chiu PW, Shabbir A, So JB. Endoscopy. 2015;47 Suppl 1 UCTN:E232-3. doi: 10.1055/s-0034-1391904. Epub 2015 Jun 12. PMID: 26069978
  16. Longer examination time improves detection of gastric cancer during diagnostic upper gastrointestinal endoscopy. Teh JL, Tan JR, Lau LJ, Saxena N, Salim A, Tay A, Shabbir A, Chung S, Hartman M, So JB. Clinical gastroenterology and hepatology. 2015 Mar;13(3):480-487.e2. doi: 10.1016/j.cgh.2014.07.059. Epub 2014 Aug 10. PMID: 25117772
  17. CD44v8-10 is a cancer-specific marker for gastric cancer stem cells. Lau WM, Teng E, Chong HS, Lopez KA, Tay AY, Salto-Tellez M, Shabbir A,So JB, Chan SL. Cancer Research. 2014 May 1;74(9):2630-41. doi: 10.1158/0008-5472.CAN-13-2309. Epub 2014 Mar 11. PMID: 24618343
  18. Fiberoptic confocal raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett's esophagus. Bergholt MS, Zheng W, Ho KY, Teh M, Yeoh KG, Yan So JB, Shabbir A, Huang Z. Gastroenterology. 2014 Jan;146(1):27-32. doi: 10.1053/j.gastro.2013.11.002. Epub 2013 Nov 8. PMID: 24216327
  19. Endoscopic tri-modal imaging improves detection of gastric intestinal metaplasia among a high-risk patient population in Singapore.So J, Rajnakova A, Chan YH, Tay A, Shah N, Salto-Tellez M, Teh M, Uedo N. Dig Dis Sci. 2013 Dec;58(12):3566-75. doi: 10.1007/s10620-013-2843-2. Epub 2013 Sep 1. Erratum in: Digestive diseases and sciences. 2014 Jan;59(1):231. PMID: 23996468
  20. Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. Lei Z, Tan IB, Das K, Deng N, Zouridis H, Pattison S, Chua C, Feng Z, Guan YK, Ooi CH, Ivanova T, Zhang S, Lee M, Wu J, Ngo A, Manesh S, Tan E, Teh BT, So JB, Goh LK, Boussioutas A, Lim TK, Flotow H, Tan P, Rozen SG. Gastroenterology. 2013 Sep;145(3):554-65. doi: 10.1053/j.gastro.2013.05.010. Epub 2013 May 14. PMID: 23684942

Professional Memberships

American Society of Gastrointestinal Endoscopy (ASGE)
Society of American Gastrointestinal & Endoscopic Surgeons (SAGES)
International Gastric Cancer Association (IGCA)
Society of Surgery for Alimentary Tract
International Society of Diseases of Esophagus (ISDE)