Prof James Hui specialises in the management of orthopaedic problems in children, as well as general orthopaedics. His special areas of interest are the care, rehabilitation and surgical treatment of musculoskeletal problems occurring in infants and children, such as hip dysplasia and dislocation, foot deformities, spinal deformities, limb length discrepancies and neuromuscular disorders such as Cerebral Palsy, Spina Bifida and Muscular Dystrophy.

Prof Hui completed his medical degree at the National University of Singapore. He subsequently completed his surgical and orthopaedic training at the National University Hospital, Singapore. He is a fellowship-trained paediatric orthopaedic surgeon, having spent a year in Australia on a paediatric orthopaedic fellowship. Prof Hui is actively involved in undergraduate and postgraduate teaching at NUS. He is a member of numerous professional societies including the Paediatric Orthopaedic Society of North America, the Asia Pacific Orthopaedic Association and the Singapore Medical Association. Prof Hui is actively involved in clinical and basic science research.

Some of his research interests over the years are listed below:-
- glenoid version in children with Erb's palsy
- Gait analysis in cerebral palsy
- prevelance of scoliosis in Singapore
- bone age and growth in children
- healing of articular cartilage defects using mesenchymal stem cells and chondrocytes
- effect of growth factors on the physis