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Emergency Medicine Department

Our Research

NUH EMD believes in creating an environment of vibrant research and opportunities.

Our Key Research Areas are currently in:--

  • Emergency Cardiac Care, specifically biomarkers for acute coronary syndromes and heart failure
  • Critical Care, specifically Sepsis and Non-invasive ventilation (NIV)
  • Observation Medicine
  • Resuscitation, specifically Shock and Hypothermia
  • Trauma


Published Articles

  1. Kuan WS, Mahadevan M. Emergency unscheduled returns: can we do better? Singapore Med J. 2009 Nov; 50 (11): 1068-71
  2. Sim TB. Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State. Critical Decisions in Emergency Medicine. 2009 Sept;24(1):2-10.
  3. Kuan WS, Quek LS. Stridor in an adult: not just a child's disease. Eur J Emerg Med. 2009 Apr;16(2):109-10.
  4. Kuan WS, Ooi SBS. A Dusky Hand - Expect the Unexpected. Int J Emerg Med. 2009 Apr;2(1):53-4.
  5. Yeo YYC, Lee SK, Lim CY, Quek LS, Ooi SBS. A review of elderly injuries seen in a Singapore emergency department. Singapore Med J. 2009 Mar;50(3):278-83.
  6. Ingram PR, Mahadevan M, Fisher DA. Dengue management: practical and safe hospital-based outpatient care. Trans R Soc Trop Med Hyg. 2009 Feb;103(2):203-5.
  7. Subramaniam R, Ooi SBS. Oozing puncture wound on foot. J Fam Pract. 2009 Jan;58(1):37-9.
  8. Ibrahim IB. It is time to label sepsis as a public health problem. J Crit Care. 2008 Dec;23(4):452-3.
  9. Ibrahim IB, Ooi SBS, Chan YH, Sethi S. Point-of-care bedside gas analyzer: Limited use of venous pC02 in emergency patients. J Emerg Med. 2008;Accepted 20 April 2008. Available online 18 October 2008.
  10. Lee C-H, Ooi SBS, Tay EL, Low AF, Teo S-G, Lau C, Tai BC, Lim I, Lam S, Lim IH, Chai P, Tan HC. Shortening of median door-to-balloon time in primary percutaneous coronary intervention in Singapore by simple and inexpensive operational measures: clinical practice improvement program. J Interv Cardiol. 2008 Oct;21(5):414-23.
  11. Quek LS, Eray O. Occult Aortic Rupture Related to Blunt Thoracic Trauma: A Review of Current Literature. Turk J Emerg Med 2008;8(2):95-102.
  12. Sim TB, Seet CM. To study the effectiveness and safety of ketamine and midazolam procedural sedation in the incision and drainage of abscesses in the adult emergency department. Eur J Emerg Med. 2008 Jun;15(3):169-72.
  13. Punyadasa AC, Tee A. 'Pseudopneumothorax'-Hold that chest tube! Int J Emerg Med 2008 Apr;1(1):59-60.
  14. Ong VYK, Tan KHS. No air leak on PPV does not exclude tracheobronchial injury after blunt chest trauma. Heart Lung Circ. 2008 Apr;17(2):163-6.
  15. Ong MEH, Tan EH, Yan X, Anushia P, Lim SH, Leong BS-H, Ong VYK, Lim T, Yap S, Overton J, Anatharaman V. An observational study describing the geographic-time distribution of cardiac arrests in Singapore: what is the utility of geographic information systems for planning public access defibrillation? (PADS Phase I). Resuscitation. 2008 Mar;76(3):388-96.
  16. Sim TB. NSAIDS-induced anaphylaxis precipitating acute coronary vasospasm. Eur J Emerg Med. 2008 Feb;15(1):48-50.
  17. Ong MEH, Tan EH, Ng FSP, Panchalingham A, Lim SH, Manning PG, Ong VYK, Lim SH, Yap S, Tham LP, Ng KS, Venkataraman A. ( for CARE study group: Cardiac Arrest and Resuscitation Epidemiology Study Group). Survival outcomes with the introduction of intravenous epinephrine in the management of out-of-hospital cardiac arrest.[see comment]. Ann Emerg Med. 2007 Dec;50(6):635-42.
  18. Kuan WS, Lee SK, Ooi SBS. Chronic voice hoarseness: when is it an emergency? Eur J Emerg Med. 2007 Dec;14(6):360-2
  19. Ong MEH, Tan EH, Ng FSP, Yap S, Panchalingham A, Leong BS-H, Ong VYK, Tiah L, Lim SH, Venkataraman A; CARE study group. Comparison of termination-of-resuscitation guidelines for out-of-hospital cardiac arrest in Singapore EMS. Resuscitation. 2007 Nov;75(2):244-51.
  20. Wong LL, Ooi SBS, Goh LG. Patients' complaints in a hospital emergency department in Singapore. Singapore Med J. 2007 Nov;48(11):990-5.
  21. Ong MEH, Yan X, Lau G, Tan EH, Panchalingham A, Leong BS-H, Ong VYK, Tiah L, Yap S, Lim SH, Venkataraman A. Out-of-hospital cardiac arrests occurring in primary health care facilities in Singapore. Resuscitation. 2007 Jul;74(1):38-43.
  22. Sim TB, Ooi SBS. A fatal case of missed appendicitis. Hong Kong J Emerg Med. 2007 Jul;14(3):179-82.
  23. Wee EWL, Ooi SBS. An unusual cause of 'ptosis'. J Emerg Med. 2007 Apr;32(3):267-70.
  24. Chong AKS, Tan DMK, Ooi SBS, Mahadevan M, Lim AYT, Lim BH. Comparison of forearm and conventional Bier's blocks for manipulation and reduction of distal radius fractures.[see comment]. J. 2007 Feb;32(1):57-9.
  25. Tan C, Pillai S, Manning PG. Electrocardiographical case. A man found unconscious. Singapore Med J. 2006 Aug;47(8):730-4; quiz 735.
  26. Ooi SBS, Iau PTC. Bicycle protection laws in Singapore: are more compelling data still needed? Singapore Med J. 2006 May;47(5):357-8.
  27. Ong VYK, Habibah AK, Lee FCY. Safety among foreign workers and impact on emergency medicine services in Singapore. Singapore Med J. 2006 Feb;47(2):121-8.
  28. Zhu YZ, Chong CL, Chuah SC, Huang SH, Nai HS, Tong HT, Whiteman M, Moore PK. Cardioprotective effects of nitroparacetamol and paracetamol in acute phase of myocardial infarction in experimental rats. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H517-24.
  29. Seet RCS, Ooi SBS, Mak KSW, Lim ECH. Close temporal association of bronchial asthma and ischemic colitis--case report and review of the literature. Respir Med. 2005 Feb;99(2):250-3.
  30. Khoo K-L, Leng P-H, Ibrahim IB, Lim TK. The changing face of healthcare worker perceptions on powered air-purifying respirators during the SARS outbreak. Respirology. 2005 Jan;10(1):107-10.
  31. Beng ST, Mahadevan M. An uncommon life-threatening complication after chest tube drainage of pneumothorax in the ED. Amer J of Emerg Med. 2004 Nov;22(7):615-9.
  32. Ibrahim IB, Seet CM, Manning PG. Emergency physician versus cardiologist-initiated thrombolysis for acute myocardial infarction: a Singapore experience. Singapore Med J. 2004 Jul;45(7):313-7.
  33. Ooi SBS, Tambyah PA. Transmission of severe acute respiratory syndrome in an emergency department. Am J Med. 2004 Apr 1;116(7):486-9.
  34. Ong MEH, Ooi SBS, Manning PG. A review of 2,517 childhood injuries seen in a Singapore emergency department in 1999--mechanisms and injury prevention suggestions. Singapore Med J. 2003 Jan;44(1):12-9.
  35. Hock MOE, Ooi SBS, Saw SM, Lim SH. A randomized controlled trial comparing the hair apposition technique with tissue glue to standard suturing in scalp lacerations (HAT study). [summary for patients in J Fam Pract. 2002 Oct;51(10):818; PMID: 12401146]. Ann Emerg Med. 2002 Jul;40(1):19-26.
  36. Mahadevan M, Jin A, Manning PG, Lim TK. Emergency department asthma: compliance with an evidence-based management algorithm. Ann Acad Med Singapore. 2002 Jul;31(4):419-24.
  37. Ho KK, Lee SW, Ooi SBS, Lateef F, Lim SH, Anantharaman V. Acute coronary syndrome--factors causing delayed presentation at the Emergency Department. Ann Acad Med Singapore. 2002 May;31(3):387-92.
  38. Lee FC, Chong WF, Chong P, Ooi SBS. The emergency medicine department system: a study of the effects of computerization on the quality of medical records. Eur J Emerg Med. 2001 Jun;8(2):107-15.
  39. Manning PG. The constantly changing role of the emergency physician in the management of the patient with an acute coronary syndrome.[comment]. Singapore Med J. 2001 Feb;42(2):49-51.
  40. Mahadevan M, Graff L. Prospective randomized study of analgesic use for ED patients with right lower quadrant abdominal pain. Amer J of Emerg Med. 2000 Nov;18(7):753-6.
  41. Ooi SBS, Lim YT, Lau TC, Chia BL, Pillai S, Liu T. Value of troponin-T rapid assay, cardiac enzymes, electrocardiogram and history of chest pain in the initial diagnosis of myocardial infarction in the emergency department. Eur J Emerg Med. 2000 Jun;7(2):91-8.
  42. Chong CL, Ooi SBS. Neck pain after minor neck trauma--is it always neck sprain? Eur J Emerg Med. 2000 Jun;7(2):147-9.
  43. Ooi SBS. Dog, Cat and Human Bites. The Singapore Family Physician 1999 Dec;5(4):9-12.
  44. Seet CM. Clinical presentation of patients with subarachnoid haemorrhage at a local emergency department. Singapore Med J. 1999 Jun;40(6):383-5.
  45. Ooi SBS, Kour NW, Mahadev A. Haematuria in the diagnosis of urinary calculi. Ann Acad Med Singapore. 1998 Mar;27(2):210-4.
  46. Seet CM. Efficacy of intravenous adenosine in treatment of paroxysmal supraventricular tachycardia in the local population. Singapore Med J. 1997 Dec;38(12):525-8.
  47. Ooi SBS, Koh-Tai BC, Aw TC, Lau TC, Chan ST. Assessment of dehydration in adults using hematologic and biochemical tests. Acad Emerg Med. 1997 Aug;4(8):840-4.
  48. Ooi SBS. Emergency department complaints: a ten-year review. Singapore Med J. 1997 Mar;38(3):102-7.
  49. Ooi SBS. Electrocardiographic clinical diagnosis in a drowsy and tachypnoeic patient. Singapore Med J. 1995 Dec;36(6):666, 690-1
  50. Ooi SBS. Differential diagnosis of electrocardiographic changes in altered mental state. Singapore Med J. 1995 Oct;36(5):549,571-2


Poster Presentations

Title and AuthorsConference(s)

The Importance of Measuring Oxygen Debt in Hemorrhagic Shock.

Benjamin Leong, Mohamad Tiba, Gerald Drauker, Juliana Medina, William Holbert, Robert Barbee, Penny Reynolds, Kevin Ward

American Heart Association Resuscitation Science Symposium:--
Best Original Resuscitation Science, Moderated Poster Session
2009 (Nov) Florida, USA


Oxygen Transport in Post Cardiac Arrest Syndrome With Goal Directed Hemodynamic Optimization.

Benjamin Leong, Nathan White, Mohamad Tiba, William Holbert, Gerald Drauker, Juliana Medina, Mary A Perberdy, Joseph P Ornato, Kevin Ward

American Heart Association Resuscitation Science Symposium:--
Best Original Resuscitation Science, Moderated Poster Session
2009 (Nov) Florida, USA


Clinical Performance of Combined Use of Canadian CT Head Rule (CCHR) with serum S100 protein in Evaluation of Minor Head Injury (MHI) patients in the Emergency Department.

Peng Li Lee

a) 8th National HealthCare Group Annual Scientific Congress 2009:
--NUS Leadership in Research (Oct) Singapore
b) 8th National HealthCare Group Annual Scientific Congress 2009 (Oct) Singapore


Evidence-based quality review and improvement of In-Hospital Cardiac Arrest Response - NUH Cardiac Arrest Registry.

Benjamin Leong

8th National HealthCare Group Annual Scientific Congress 2009:--
NUS Leadership in Research (Oct) Singapore


Patterns of Limb Injuries in Motorcyclists Involved in Road Traffic Accidents Seen at An Emergency Department in Singapore.

Seet Chong Meng , Brandon Koh


6th National Healthcare Group (NHG) Annual Scientific Congress
2007 (Nov) Singapore


Public Access Defibrillation in Singapore. What is the Geographic Time Distribution?

Marcus Ong, Benjamin Leong


6th National Healthcare Group (NHG) Annual Scientific Congress
2007 (Nov) Singapore


Fatty Acid-Binding protein, creatine kinase- MB mass, electrocardiogram and myoglobin (TroFCEM Study) in rapid bedside diagnosis of ACS in chest pain patients presenting to an ED.

Shirley Ooi BS, Ling Lien Hsi

a) 6th National Healthcare Group (NHG) Annual Scientific Congress
2007 (Nov) Singapore
b) 8th Society for Emergency Medicine in Singapore (SEMS) Annual Scientific Congress Meeting 2007 (May) Singapore


Falls in the Elderly - An Emergency Room Perspective.

Lee Sock Koon


Hong Kong Scientific Symposium on Emergency Medicine
2007 (Oct) Hong Kong


Patients with Haemolytic complications of Warfarin Presenting to the Emergency Department.

Seet Chong Meng, Soma Subramaniam


5th National Healthcare Group (NHG) Annual Scientific Congress
2006 (Oct) Singapore


Improving patient outcomes in COPD exacerbations

Irwani Bte Ibrahim


Ministry of Health Clinical Quality Poster Competition 2006 Singapore
(Awarded 1st prize)


Non invasive ventilation initiated in the emergency department is just as effective as in the intensive care.

Irwani Bte Ibrahim, Jason Phua, Peter G Manning and Tow Keang Lim.


15th Annual Congress of the European Respiratory Society (ERS)
2005 (Aug) Copenhagen, Denmark

D-Dimer HSRP Chest Pain Study.

Chong Chew Lan, Malcolm Mahadevan


American College of Emergency Physician Scientific Assembly
2004 (Oct) Seattle, USA


Diagnostic accuracy for patients admitted through NUH Emergency Department.

Lee Kuan Wee, Shirley Ooi


BS 3rd National Healthcare Group (NHG) Annual Scientific Congress
2004 (Oct) Singapore


Elderly Utilization of Emergency Services and Its Outcome.

Lee Sock Koon, Malcolm Mahadevan

3rd National Healthcare Group (NHG) Annual Scientific Congress
2004 (Oct) Singapore


Oral Presentations

Implementation of a 6-Hour Severe Sepsis Bundle in Multiple Asian Countries Is Associated With Decreased Mortality.

Sungwon Na, Mahesh Joshi, Chih-huang Li, Malcolm Mahadevan, Amit Varma, Chien-Chang Lee, Sumit Ray, Lu Yiming, Kuan Win Sen, Bhavini Jaiswal, H Bryant Nguyen


CHEST--American College of Chest Physicians Scientific Presentations and Awards:--Protocol Implementation in the ICU
2009 (Nov) San Diego, USA

Low Volume Resuscitation and repayment of Oxygen Debt from Traumatic Shock.

Benjamin Leong


Society For Academic Emergency Medicine
2009 (May) New Orleans, USA


Can Patients with Primary Spontaneous Pneumothorax be successfully managed in a 24 hours Emergency Observation Unit?

Kuan Win Sen, Kanwar S Lather, Malcolm Mahadevan


EMCOM 2008. 10th Annual International Conference of Society for Emergency Medicine in India 2008 (Nov) Salem, India


Unscheduled Returns to the Emergency Department - Are They Warranted?

Kuan Win Sen, Malcolm Mahadevan


10th Society for Emergency Medicine in Singapore (SEMS) Annual
Scientific Meeting
2008 (Mar) Singapore


Factors Predicting Survival in Out-of-hospital Cardiac Arrest.

Benjamin Leong, Marcus Ong et al


6th National Healthcare Group (NHG) Annual Scientific Congress
2007 (Nov) Singapore


An Audit on the Efficacy of Various Antiemetic Medications in the Management of Vomiting at the Children's Emergency.

Ong Pei Yuin


7th Singapore Emergency Medicine Society (SEMS) Annual Scientific Meeting
2006 (Mar) Singapore

Incremental Value of serial ECGs and point-of-care
cardiac markers in diagnosing ACS in low to intermediate risk patients with a nondiagnostic initial ECG.

Shirley Ooi BS, Ling Lien Hsi

a) 3rd Asian Conference on Emergency Medicine 2004 (Oct) Hong Kong
b) 2nd National Healthcare Group (NHG) Annual Scientific Congress
2003 (Oct) Singapore
(Best Medical Paper Award)
c) 4th Singapore Emergency Medicine Society (SEMS) Annual Scientific Meeting
2003 (Mar) Singapore
d) 9th International Conference on Emergency Medicine (ICEM) 2002 (Jun) Edinburgh, UK