Paediatric Renal and Transplant Immunology Research Group

RESEARCH FOCUS

Immune mechanisms in glomerulonephritis

1. Cytokines and glomerulonephritis
2. Pathogenesis of idiopathic nephrotic syndrome in childhood
3. Immunogenetics of familial nephritis




Transplant immunology




1. Identification and characterization of the immunosuppressive effects of Chinese medication:
   • Isolation of the active fraction of herb X used in the treatment of lupus nephritis
   • Characterization of the biologic activity (immunosuppressive) of the active fraction of herb X
   • In-vivo testing of the biologic activity of the active fraction of herb X on 2 animal models:
     • Rat lung allograft rejection model
     • Lupus nephritis model in Mrl/lpr mouse 2. Immune tolerance in renal transplant 3
2. CMV infection in solid organ transplantation
   • Role of CMV infection in chronic allograft dysfunction
   • The study of CMV mutants with widespread use of ganciclovir prophylaxis and how to overcome the mechanisms by which these mutants achieve drug resistance. Singapore Renal Registry Epidemiology of renal diseases in Singapore including end-stage renal disease.

Overseas Collaborator:
Prof. Stanley C. Jordan
Transplant Immunology Laboratory
Cedars-Sinai Medical Center
UCLA School of Medicine
Los Angeles, CA, USA