Department of PathologyOur Services
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Histopathology
The histopathology section offers a comprehensive range of diagnostic services that encompass a wide variety of diseases and systemic pathology. The scope of services includes the following:
- Routine and specialised surgical pathology work
- Intra-operative / frozen section consultation
- Special investigations for renal biopsy, muscle biopsy, skin biopsy, nerve biopsy and liver biopsy
- Expert consultation for subspecialty
- Electron microscopy for renal, muscle and skin panel
- Transplant pathology service (including liver and renal transplant pathology)
- A comprehensive range of histochemical stains
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Immunohistochemistry
This section provides a comprehensive range of immunohistochemical services. The recent acquisition of modern automated immunostainers has further optimised, consolidated and expanded our diagnostic and research services providing fast, quality and standardised results.
- Immunoflourescence: Direct immunoflourescence is offered for skin and renal biopsies
- Muscle enzyme histochemical stain: Standard panel of stains are provided for fresh muscle biopsy
- Immunohistochemistry: We have over 100 antibodies that are utilised for diagnosis and prognosis of many tumours and disease conditions
- In-Situ-Hybridisation
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Cytopathology
This section provides cytopathology services in the following areas:
- Gynaecological Cytology: Over 14000 cervical samples (conventional or liquid base) are received for screening and diagnosis every year. We also provide HPV testing.
- Non Gynaecological Cytology: Over 5000 of these samples are received every year to diagnose tumours or neoplasms, to detect pathogenic agents (e.g. infection) and certain material (e.g. uric crystals). These include body cavity fluids, and washings and brushings from various parts of the body. Ancillary tests such as immunocytochemistry, cell block preparation, molecular markers, flow cytometry and various special stains can be performed on these samples to enhance the sensitivity and accuracy of the investigation.
- Fine Needle Aspiration (FNA) Service: FNA is a quick, minimally invasive test to aspirate diagnostic material from a tumour or lesion. It is an effective and rapid test in determining adequacy of sampling and therefore, providing early preliminary results. It is also extremely useful in the diagnosis and treatment of cysts.
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Diagnostic Molecular Oncology Centre
The Molecular Diagnostic Oncology Centre (DMOC) is a laboratory accredited by the College of American Pathologists and focused on the molecular diagnostics of Solid Tumors, including the molecular analysis of samples diagnosed by surgical pathologists or histopathologists and cytopathologists in the traditional way. It is at the core of personalised medicine or therapeutic pathology.
DMOC started its operation in late 2007 and, since then, has become a key laboratory for oncology molecular testing in Asia. With a current volume of more than 1,500 samples per year. DMOC receives a large portion of its work from private hospitals within Singapore and from overseas institutions. It is currently the reference laboratory for several pharmaceutical companies for the development of high-quality molecular testing in the area of personalised/therapeutic medicine, and it is the reference laboratory for several ongoing clinical trials sponsored by the industry.
DMOC is specialised in tissue-based molecular diagnosis and, in particular, in the interface between tissue morphology, immunohistochemistry, hybridisation techniques and PCR-based technology, providing a 1-stop laboratory for integrated pathology tissue diagnosis.
As the development of new tests is constant in our setting, we welcome enquiries about tests that are not included in our request form at this time.
A short guide on sample submission, tissue requirements, turnaround time and costing, among others, can be requested from DMOC as well.
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