(Wilder-Smith E, Chan YC)
The Neurology Diagnostic Laboratory researches all aspects of peripheral nerve disease. The research focuses on both clinical and basic aspects of diabetic neuropathy and carpal tunnel disease. Novel diagnostic techniques have been devised for improved testing of small nerve fibre impairment.
Research is divided up in the following:
Animal research:
- Nerve conduction techniques in rabbits with diabetic neuropathy
- Effect of autologous bone marrow transplant on progression and reversal of diabetic neuropathy in diabetic rabbits
Clinical neurophysiology:
- Carpal Tunnel Syndrome and other nerve entrapment syndromes
- Small nerve fibre neuropathy and novel diagnostic techniques which include skin biopsy
- Standardisation of neurophysiological tests of small nerve fibres
- Diabetic Neuropathy
- Novel techniques for investigating peripheral nerve pathology (ultrasound)
- Clinical applications of rTMS
- Quantification of vigilance using EEG and
evoked potentials
Strong research links have been established between the Department of Engineering (A/P Li XP at the Neurosensors Laboratory) and the Neurology Diagnostic Laboratory. Research on the central nervous system includes sleep and fatigue detection and its quantification using novel forms of analysis. Peripheral nerve research involves devising new methods for measuring small nerve fibre dysfunction (Neurosensors laboratory at NUS dept of engineering).
(Wilder-Smith E, Rahul Rathakrishnan)
Research interest centers on clinical disease classification and treatment. We recently have started profiling risk factors for seizure recurrence and biological mechanisms of seizure resistance.
(June Tan, Erle Lim)
The movement disorders clinic engages in clinical research on how best to manage Parkinsons disease, tremors and other involuntary movements. A particular interest is in Botulinum toxin injection which is also given very accurately under electrical guidance provided by EMG.
 (Ong BK)
The clinical features of Myasthenia Gravis are being correlated to
various immunological parameters.
Treatment optimisation for the inflammatory neuropathies are being
investigated.
(Bernard Chan, Vijay Sharma, Teoh HL, L Tan)
Stroke research focuses on clinical research with new treatments being investigated for stroke in multicentre trials.
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